BE 2254

    WARNING: This product is for research use only, not for human or veterinary use.

MedKoo CAT#: 584137

CAS#: 40077-13-2

Description: BE 2254 is an adrenergic agent and antagonist of central noradrenergic receptor stimulation.


Price and Availability

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BE 2254 is not in stock, may be available through custom synthesis. For cost-effective reason, minimum 1 gram order is requested. The product will be characterized by NMR, HPLC and MS analysis. Purity (HPLC) is usually >98%. CoA, QC data, MSDS will be provided when product is successfully made. The estimated lead time is 2-3 months. Please send email to sales@medkoo.com to inquire quote.


Chemical Structure

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Theoretical Analysis

MedKoo Cat#: 584137
Name: BE 2254
CAS#: 40077-13-2
Chemical Formula: C19H21NO2
Exact Mass: 295.1572
Molecular Weight: 295.38
Elemental Analysis: C, 77.26; H, 7.17; N, 4.74; O, 10.83


Synonym: BE 2254; BE-2254; BE2254

IUPAC/Chemical Name: 1(2H)-Naphthalenone, 3,4-dihydro-2-(((2-(4-hydroxyphenyl)ethyl)amino)methyl)-

InChi Key: PZZOEXPDTYIBPI-UHFFFAOYSA-N

InChi Code: InChI=1S/C19H21NO2/c21-17-9-5-14(6-10-17)11-12-20-13-16-8-7-15-3-1-2-4-18(15)19(16)22/h1-6,9-10,16,20-21H,7-8,11-13H2

SMILES Code: O=C1C(CNCCC2=CC=C(O)C=C2)CCC3=C1C=CC=C3


Technical Data

Appearance:
Solid powder

Purity:
>98% (or refer to the Certificate of Analysis)

Shipping Condition:
Shipped under ambient temperature as non-hazardous chemical. This product is stable enough for a few weeks during ordinary shipping and time spent in Customs.

Storage Condition:
Dry, dark and at 0 - 4 C for short term (days to weeks) or -20 C for long term (months to years).

Solubility:
Soluble in DMSO

Shelf Life:
>2 years if stored properly

Drug Formulation:
This drug may be formulated in DMSO

Stock Solution Storage:
0 - 4 C for short term (days to weeks), or -20 C for long term (months).

Harmonized System Code:
293490


References

1: Szreder Z. The effect of BE 2254 on the metabolic response stimulated by pyrogen in rabbits. Gen Pharmacol. 1993 Jan;24(1):177-83. PubMed PMID: 8097739.

2: Adams A, Jarrott B. Thermodynamics of agonist and antagonist binding to the alpha 1-adrenoceptor studied using [125I]BE 2254. Biochem Biophys Res Commun. 1985 Apr 30;128(2):816-23. PubMed PMID: 2986627.

3: Adams A, Jarrott B. Deafferentation of the rat hippocampus does not alter the affinity or binding capacity for the alpha 1-adrenoceptor radioligand [125I]BE 2254. Neurosci Lett. 1984 Dec 21;52(3):311-6. PubMed PMID: 6097843.

4: Schlicker E, Brodde OE, Göthert M, Schaperdoth M. Increased affinity and preference of halogenated derivatives of BE 2254 for alpha 1-adrenoceptors demonstrated by functional and binding experiments. J Cardiovasc Pharmacol. 1984 Nov-Dec;6(6):1238-44. PubMed PMID: 6084785.

5: Göthert M, Dieckhöfer C, Nolte J. Preferential blockade of alpha 1-adrenoceptors in the rabbit pulmonary artery by derivatives of beta-phenylethylamine chemically related to BE 2254 (heat). J Cardiovasc Pharmacol. 1983 Jan-Feb;5(1):12-8. PubMed PMID: 6186846.

6: Engel G, Hoyer D. [125Iodo]BE 2254, a new radioligand for alpha 1-adrenoceptors. J Cardiovasc Pharmacol. 1982;4 Suppl 1:S25-9. PubMed PMID: 6175839.

7: Hicks PE. Antagonism of pre and postsynaptic alpha-adrenoreceptors by BE 2254 (HEAT) and prazosin. J Auton Pharmacol. 1981 Dec;1(5):391-7. PubMed PMID: 6123512.

8: Engel G, Hoyer D. [125I]BE 2254, a new high affinity radioligand for alpha 1-adrenoceptors. Eur J Pharmacol. 1981 Jul 17;73(2-3):221-4. PubMed PMID: 6273186.

9: Göthert M, Nolte J, Weinheimer G. Preferential blockade of postsynaptic alpha-adrenoceptors by BE 2254. Eur J Pharmacol. 1981 Mar 5;70(1):35-42. PubMed PMID: 6111463.

10: Heinz N, Hofferber E. [On the pharmacology of the alpha-receptor blocker BE 2254 (HEAT) (author's transl)]. Arzneimittelforschung. 1980;30(12):2135-9. German. PubMed PMID: 6111325.

11: Clineschmidt BV, Pflueger AB, Bunting PR, McGuffin JC, Ballentine RJ. Central catecholamine receptor blocking actions of BE-2254 ('heat'): comparison with chlorpromazine and haloperidol. Eur J Pharmacol. 1975 Jun-Jul;32(02):279-86. PubMed PMID: 1171016.