BE 2254

    WARNING: This product is for research use only, not for human or veterinary use.

MedKoo CAT#: 584137

CAS#: 40077-13-2

Description: BE 2254 is an adrenergic agent and antagonist of central noradrenergic receptor stimulation.

Chemical Structure

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BE 2254
CAS# 40077-13-2
Instruction

Theoretical Analysis

MedKoo Cat#: 584137
Name: BE 2254
CAS#: 40077-13-2
Chemical Formula: C19H21NO2
Exact Mass: 295.16
Molecular Weight: 295.380
Elemental Analysis: C, 77.26; H, 7.17; N, 4.74; O, 10.83

Price and Availability

This product is not in stock, which may be available by custom synthesis. For cost-effective reason, minimum order is 1g (price is usually high, lead time is 2~3 months, depending on the technical challenge). Quote less than 1g will not be provided. To request quote, please email to sales @medkoo.com or click below button.
Note: Price will be listed if it is available in the future.

Request quote for custom synthesis

Synonym: BE 2254; BE-2254; BE2254

IUPAC/Chemical Name: 1(2H)-Naphthalenone, 3,4-dihydro-2-(((2-(4-hydroxyphenyl)ethyl)amino)methyl)-

InChi Key: PZZOEXPDTYIBPI-UHFFFAOYSA-N

InChi Code: InChI=1S/C19H21NO2/c21-17-9-5-14(6-10-17)11-12-20-13-16-8-7-15-3-1-2-4-18(15)19(16)22/h1-6,9-10,16,20-21H,7-8,11-13H2

SMILES Code: O=C1C(CNCCC2=CC=C(O)C=C2)CCC3=C1C=CC=C3

Appearance: Solid powder

Purity: >98% (or refer to the Certificate of Analysis)

Shipping Condition: Shipped under ambient temperature as non-hazardous chemical. This product is stable enough for a few weeks during ordinary shipping and time spent in Customs.

Storage Condition: Dry, dark and at 0 - 4 C for short term (days to weeks) or -20 C for long term (months to years).

Solubility: Soluble in DMSO

Shelf Life: >2 years if stored properly

Drug Formulation: This drug may be formulated in DMSO

Stock Solution Storage: 0 - 4 C for short term (days to weeks), or -20 C for long term (months).

HS Tariff Code: 2934.99.9001

More Info:

Biological target:
In vitro activity:
In vivo activity:

Preparing Stock Solutions

The following data is based on the product molecular weight 295.38 Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.

Recalculate based on batch purity %
Concentration / Solvent Volume / Mass 1 mg 5 mg 10 mg
1 mM 1.15 mL 5.76 mL 11.51 mL
5 mM 0.23 mL 1.15 mL 2.3 mL
10 mM 0.12 mL 0.58 mL 1.15 mL
50 mM 0.02 mL 0.12 mL 0.23 mL
Formulation protocol:
In vitro protocol:
In vivo protocol:

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1: Szreder Z. The effect of BE 2254 on the metabolic response stimulated by pyrogen in rabbits. Gen Pharmacol. 1993 Jan;24(1):177-83. PubMed PMID: 8097739.

2: Adams A, Jarrott B. Thermodynamics of agonist and antagonist binding to the alpha 1-adrenoceptor studied using [125I]BE 2254. Biochem Biophys Res Commun. 1985 Apr 30;128(2):816-23. PubMed PMID: 2986627.

3: Adams A, Jarrott B. Deafferentation of the rat hippocampus does not alter the affinity or binding capacity for the alpha 1-adrenoceptor radioligand [125I]BE 2254. Neurosci Lett. 1984 Dec 21;52(3):311-6. PubMed PMID: 6097843.

4: Schlicker E, Brodde OE, Göthert M, Schaperdoth M. Increased affinity and preference of halogenated derivatives of BE 2254 for alpha 1-adrenoceptors demonstrated by functional and binding experiments. J Cardiovasc Pharmacol. 1984 Nov-Dec;6(6):1238-44. PubMed PMID: 6084785.

5: Göthert M, Dieckhöfer C, Nolte J. Preferential blockade of alpha 1-adrenoceptors in the rabbit pulmonary artery by derivatives of beta-phenylethylamine chemically related to BE 2254 (heat). J Cardiovasc Pharmacol. 1983 Jan-Feb;5(1):12-8. PubMed PMID: 6186846.

6: Engel G, Hoyer D. [125Iodo]BE 2254, a new radioligand for alpha 1-adrenoceptors. J Cardiovasc Pharmacol. 1982;4 Suppl 1:S25-9. PubMed PMID: 6175839.

7: Hicks PE. Antagonism of pre and postsynaptic alpha-adrenoreceptors by BE 2254 (HEAT) and prazosin. J Auton Pharmacol. 1981 Dec;1(5):391-7. PubMed PMID: 6123512.

8: Engel G, Hoyer D. [125I]BE 2254, a new high affinity radioligand for alpha 1-adrenoceptors. Eur J Pharmacol. 1981 Jul 17;73(2-3):221-4. PubMed PMID: 6273186.

9: Göthert M, Nolte J, Weinheimer G. Preferential blockade of postsynaptic alpha-adrenoceptors by BE 2254. Eur J Pharmacol. 1981 Mar 5;70(1):35-42. PubMed PMID: 6111463.

10: Heinz N, Hofferber E. [On the pharmacology of the alpha-receptor blocker BE 2254 (HEAT) (author's transl)]. Arzneimittelforschung. 1980;30(12):2135-9. German. PubMed PMID: 6111325.

11: Clineschmidt BV, Pflueger AB, Bunting PR, McGuffin JC, Ballentine RJ. Central catecholamine receptor blocking actions of BE-2254 ('heat'): comparison with chlorpromazine and haloperidol. Eur J Pharmacol. 1975 Jun-Jul;32(02):279-86. PubMed PMID: 1171016.