BDF 9148

    WARNING: This product is for research use only, not for human or veterinary use.

MedKoo CAT#: 584134

CAS#: 120838-62-2

Description: BDF 9148 is a Na(+)-channel modulator as well as a congener of DPI 201-106, and was found to increase the contractile force of guinea-pig atria and papillary muscles.


Price and Availability

Size
Price

Size
Price

Size
Price

BDF 9148 is not in stock, may be available through custom synthesis. For cost-effective reason, minimum 1 gram order is requested. The product will be characterized by NMR, HPLC and MS analysis. Purity (HPLC) is usually >98%. CoA, QC data, MSDS will be provided when product is successfully made. The estimated lead time is 2-3 months. Please send email to sales@medkoo.com to inquire quote.


Chemical Structure

img

Theoretical Analysis

MedKoo Cat#: 584134
Name: BDF 9148
CAS#: 120838-62-2
Chemical Formula: C28H27N3O3
Exact Mass: 453.2052
Molecular Weight: 453.54
Elemental Analysis: C, 74.15; H, 6.00; N, 9.27; O, 10.58


Synonym: BDF 9148; BDF-9148; BDF9148

IUPAC/Chemical Name: 1H-Indole-2-carbonitrile, 4-(3-((1-(diphenylmethyl)-3-azetidinyl)oxy)-2-hydroxypropoxy)-

InChi Key: KQQFGABYYXEKDM-UHFFFAOYSA-N

InChi Code: InChI=1S/C28H27N3O3/c29-15-22-14-25-26(30-22)12-7-13-27(25)34-19-23(32)18-33-24-16-31(17-24)28(20-8-3-1-4-9-20)21-10-5-2-6-11-21/h1-14,23-24,28,30,32H,16-19H2

SMILES Code: N#CC(N1)=CC2=C1C=CC=C2OCC(O)COC3CN(C(C4=CC=CC=C4)C5=CC=CC=C5)C3


Technical Data

Appearance:
Solid powder

Purity:
>98% (or refer to the Certificate of Analysis)

Shipping Condition:
Shipped under ambient temperature as non-hazardous chemical. This product is stable enough for a few weeks during ordinary shipping and time spent in Customs.

Storage Condition:
Dry, dark and at 0 - 4 C for short term (days to weeks) or -20 C for long term (months to years).

Solubility:
Soluble in DMSO

Shelf Life:
>2 years if stored properly

Drug Formulation:
This drug may be formulated in DMSO

Stock Solution Storage:
0 - 4 C for short term (days to weeks), or -20 C for long term (months).

Harmonized System Code:
293490


References

1: Brixius K, Hoischen S, Zobel C, Lasek K, Schwinger RH. [The Ca(2+) sensitizers CGP 48506 and EMD 57033, but not the Na(+) channel modulator BDF 9148, prolong relaxation in isolated cardiomyocytes of the guinea pig]. Z Kardiol. 2001 Apr;90(4):286-91. German. PubMed PMID: 11381577.

2: Nand V, Doggrell SA. Effects of BDF 9148 on the action potentials and contractions of left ventricles from normo- and hypertensive rats. Clin Exp Pharmacol Physiol. 1999 Mar;26(3):212-9. PubMed PMID: 10081616.

3: Zobel C, Brixius K, Frank K, Schwinger RH. Effect of the Na+-channel modulator BDF 9148 on Ca2+-sensitivity and force of contraction of hypertrophic myocardium from transgene rats harboring the mouse Renin gene (TG(mREN2)27). Naunyn Schmiedebergs Arch Pharmacol. 1998 May;357(5):532-9. PubMed PMID: 9650806.

4: Doggrell SA, Liang LC. The relaxing effect of BDF 9148 on the KCl-contracted aorta isolated from normo- and hyper-tensive rats. Naunyn Schmiedebergs Arch Pharmacol. 1998 Feb;357(2):126-32. PubMed PMID: 9521485.

5: Wahl MA, Anulukanapakorn K, Ammon HP. Effect of a sodium-channel activator (BDF 9148) on insulin secretion in mouse pancreatic islets. Naunyn Schmiedebergs Arch Pharmacol. 1997 Mar;355(3):417-21. PubMed PMID: 9089675.

6: Raap A, Armah B, Mest HJ, Stenzel W, Schloos J, Blechacz W. Investigations of the mechanism of the positive inotropic action of BDF 9148: comparison with DPI 201-106 and the enantiomers. J Cardiovasc Pharmacol. 1997 Feb;29(2):164-73. PubMed PMID: 9057064.

7: Doggrell SA, Bishop BE. Veratridine augments and BDF 9148 attenuates the spontaneous contractile force of the rat portal vein. J Pharm Pharmacol. 1996 Aug;48(8):820-4. PubMed PMID: 8887732.

8: Schwinger RH, Müller-Ehmsen J, Böhm M, Erdmann E. Enantioselective inotropic actions of the Na+-channel activators BDF 9148, BDF 9196 and BDF 9167 in human failing and nonfailing myocardium. J Pharmacol Exp Ther. 1996 Mar;276(3):1180-8. PubMed PMID: 8786551.

9: Hoey A, Nankervis R, Brown L. Positive inotropic responses of the sodium channel modulator BDF 9148 in diseased rat myocardium. Clin Exp Pharmacol Physiol. 1995 Jun-Jul;22(6-7):418-22. PubMed PMID: 8582092.

10: Doggrell SA, Bishop BE, Brosch S. The effects of veratridine and BDF 9148 on the action potentials and contractility of the rat right ventricle. Gen Pharmacol. 1995 May;26(3):593-601. PubMed PMID: 7789734.

11: Amos GJ, Ravens U. The inotropic agents DPI 201-106 and BDF 9148 differentially affect potassium currents of guinea-pig ventricular myocytes. Naunyn Schmiedebergs Arch Pharmacol. 1994 Oct;350(4):426-33. PubMed PMID: 7845480.

12: Hoey A, Amos GJ, Ravens U. Comparison of the action potential prolonging and positive inotropic activity of DPI 201-106 and BDF 9148 in human ventricular myocardium. J Mol Cell Cardiol. 1994 Aug;26(8):985-94. PubMed PMID: 7799453.

13: Hoey A, Amos GJ, Wettwer E, Ravens U. Differential effects of BDF 9148 and DPI 201-106 on action potential and contractility in rat and guinea pig myocardium. J Cardiovasc Pharmacol. 1994 Jun;23(6):907-15. PubMed PMID: 7523782.

14: Baumgart D, Ehring T, Krajcar M, Skyschally A, Heusch G. Characterization of the inotropic and arrhythmogenic action of the sodium channel activator BDF 9148: a comparison to its S-enantiomer BDF 9196, to its congener DPI 201-106, to norepinephrine, and to ouabain. Basic Res Cardiol. 1994 Jan-Feb;89(1):61-79. PubMed PMID: 8010937.

15: Hoey A, Lehmkuhl A, Sadony V, Ravens U. Inotropic actions of BDF 9148 and DPI 201-106 and their enantiomers in guinea-pig, rat and human atria. Eur J Pharmacol. 1993 Feb 16;231(3):477-80. PubMed PMID: 8449239.

16: Ravens U, Wettwer E, Pfeifer T, Himmel H, Armah B. Characterization of the effects of the new inotropic agent BDF 9148 in isolated papillary muscles and myocytes of the guinea-pig heart. Br J Pharmacol. 1991 Dec;104(4):1019-23. PubMed PMID: 1667282; PubMed Central PMCID: PMC1908826.

17: Brasch H, Iven H. Inotropic and electrophysiological effects of BDF 9148, a congener of DPI 201-106, in guinea-pig atria and papillary muscles. Br J Pharmacol. 1991 Aug;103(4):1939-45. PubMed PMID: 1912981; PubMed Central PMCID: PMC1908210.

18: Herzig S, Lilienthal E, Mohr K. The positive inotropic drugs DPI 201-106, BDF 9148, and veratridine increase ouabain toxicity and [3H]ouabain binding in guinea pig heart. J Cardiovasc Pharmacol. 1991 Aug;18(2):182-9. PubMed PMID: 1717777.