BBR 2160

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MedKoo CAT#: 584132

CAS#: 118587-22-7

Description: BBR 2160 is a dihydropyridine derivative belonging to the group of the so-called tiampidine that has calcium-antagonistic properties in cardiac tissue. Intracellular microelectrodes have been used to characterize the electrophysiological properties of BBR 2160 on sheep Purkinje fibres and guinea-pig papillary muscle. BBR 2160 (10(-7) and 10(-6) M) dose dependently decreased the contractility of driven Purkinje fibre and papillary muscle. This effect was associated with a lowering of the plateau phase and a shortening of action potential duration in papillary muscle.


Price and Availability

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Pricing updated 2020-10-20. Prices are subject to change without notice.

BBR 2160 is not in stock, may be available through custom synthesis. For cost-effective reason, minimum 1 gram order is requested. The product will be characterized by NMR, HPLC and MS analysis. Purity (HPLC) is usually >98%. CoA, QC data, MSDS will be provided when product is successfully made. The estimated lead time is 2-3 months. Please send email to sales@medkoo.com to inquire quote.


Chemical Structure

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Theoretical Analysis

MedKoo Cat#: 584132
Name: BBR 2160
CAS#: 118587-22-7
Chemical Formula: C21H25N3O7S
Exact Mass: 463.1413
Molecular Weight: 463.5
Elemental Analysis: C, 54.42; H, 5.44; N, 9.07; O, 24.16; S, 6.92


Synonym: BBR 2160; BBR-2160; BBR2160

IUPAC/Chemical Name: 3,5-Pyridinedicarboxylic acid, 2-(((2-(formylamino)ethyl)thio)methyl)-1,4-dihydro-6-methyl-4-(3-nitrophenyl)-, 3-ethyl 5-methyl ester

InChi Key: CLMNTOZRDYXVRT-UHFFFAOYSA-N

InChi Code: InChI=1S/C21H25N3O7S/c1-4-31-21(27)19-16(11-32-9-8-22-12-25)23-13(2)17(20(26)30-3)18(19)14-6-5-7-15(10-14)24(28)29/h5-7,10,12,18,23H,4,8-9,11H2,1-3H3,(H,22,25)

SMILES Code: O=C(C1=C(CSCCNC=O)NC(C)=C(C(OC)=O)C1C2=CC=CC([N+]([O-])=O)=C2)OCC


Technical Data

Appearance:
Solid powder

Purity:
>98% (or refer to the Certificate of Analysis)

Shipping Condition:
Shipped under ambient temperature as non-hazardous chemical. This product is stable enough for a few weeks during ordinary shipping and time spent in Customs.

Storage Condition:
Dry, dark and at 0 - 4 C for short term (days to weeks) or -20 C for long term (months to years).

Solubility:
Soluble in DMSO

Shelf Life:
>2 years if stored properly

Drug Formulation:
This drug may be formulated in DMSO

Stock Solution Storage:
0 - 4 C for short term (days to weeks), or -20 C for long term (months).

HS Tariff Code:
2934.99.9001


References

1: Barbieri M, Masini I, Porciatti F, Cerbai E, Mugelli A. Cardiac electrophysiological effects of a new dihydropyridine calcium antagonist (BBR 2160). Pharmacol Res. 1991 Jan;23(1):87-94. PubMed PMID: 2047363.

2: Barbieri M, Cerbai E, Masini I, Porciatti F, Visentin S, Mugelli A. Effect of BBR 2160 on ICa recorded from guinea-pig isolated myocytes. Pharmacol Res. 1990 Sep-Oct;22 Suppl 3:121-2. PubMed PMID: 2097624.