AX-024 HCl
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    WARNING: This product is for research use only, not for human or veterinary use.

MedKoo CAT#: 530996

CAS#: 1704801-24-0 (HCl)

Description: AX-024 is an orally available inhibitor of the TCR-Nck interaction that selectively inhibits TCR-triggered T cell activation (IC50 value 1 nM). Inhibiting an immediate TCR signal has promise for treating a broad spectrum of human T cell-mediated autoimmune and inflammatory diseases.


Price and Availability

Size
Price

25mg
USD 190
500mg
USD 1650
Size
Price

100mg
USD 650
1g
USD 2850
Size
Price

200mg
USD 950
5g
USD 6950

AX-024 HCl, purity > 98%, is in stock. Current shipping out time is about 2 weeks after order is received. CoA, QC data and MSDS documents are available in one week after order is received.


Chemical Structure

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Theoretical Analysis

MedKoo Cat#: 530996
Name: AX-024 HCl
CAS#: 1704801-24-0 (HCl)
Chemical Formula: C21H23ClFNO2
Exact Mass: 375.1401
Molecular Weight: 375.8684
Elemental Analysis: C, 67.11; H, 6.17; Cl, 9.43; F, 5.05; N, 3.73; O, 8.51


Related CAS #: 1370544-73-2 (free base)   1704801-24-0 (HCl)    

Synonym: AX-024; AX 024; AX024 HCl; AX-024 hydrochloride

IUPAC/Chemical Name: 1-((4-(4-Fluorophenyl)-6-methoxy-2H-chromen-3-yl)methyl)pyrrolidine hydrochloride

InChi Key: DGBCIMPGYRVTPD-UHFFFAOYSA-N

InChi Code: InChI=1S/C21H22FNO2.ClH/c1-24-18-8-9-20-19(12-18)21(15-4-6-17(22)7-5-15)16(14-25-20)13-23-10-2-3-11-23;/h4-9,12H,2-3,10-11,13-14H2,1H3;1H

SMILES Code: COC1=CC(C(C2=CC=C(F)C=C2)=C(CN3CCCC3)CO4)=C4C=C1.[H]Cl


Technical Data

Appearance:
Solid powder

Purity:
>98% (or refer to the Certificate of Analysis)

Shipping Condition:
Shipped under ambient temperature as non-hazardous chemical. This product is stable enough for a few weeks during ordinary shipping and time spent in Customs.

Storage Condition:
Dry, dark and at 0 - 4 C for short term (days to weeks) or -20 C for long term (months to years).

Solubility:
Soluble in DMSO

Shelf Life:
>2 years if stored properly

Drug Formulation:
This drug may be formulated in DMSO

Stock Solution Storage:
0 - 4 C for short term (days to weeks), or -20 C for long term (months).

Harmonized System Code:
293490


References

1: Borroto A, Reyes-Garau D, Jiménez MA, Carrasco E, Moreno B, Martínez-Pasamar
S, Cortés JR, Perona A, Abia D, Blanco S, Fuentes M, Arellano I, Lobo J,
Heidarieh H, Rueda J, Esteve P, Cibrián D, Martinez-Riaño A, Mendoza P, Prieto C,
Calleja E, Oeste CL, Orfao A, Fresno M, Sánchez-Madrid F, Alcamí A, Bovolenta P,
Martín P, Villoslada P, Morreale A, Messeguer A, Alarcon B. First-in-class
inhibitor of the T cell receptor for the treatment of autoimmune diseases. Sci
Transl Med. 2016 Dec 21;8(370):370ra184. doi: 10.1126/scitranslmed.aaf2140.
PubMed PMID: 28003549.