AX-024 HCl
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MedKoo CAT#: 530995

CAS#: 1704801-24-0

Description: AX-024 is an orally available inhibitor of the TCR-Nck interaction that selectively inhibits TCR-triggered T cell activation (IC50 value 1 nM). Inhibiting an immediate TCR signal has promise for treating a broad spectrum of human T cell-mediated autoimmune and inflammatory diseases.


Price and Availability

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AX-024 HCl, purity > 98%, is in stock. Current shipping out time is about 2 weeks after order is received. CoA, QC data and MSDS documents are available in one week after order is received.


Chemical Structure

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Theoretical Analysis

MedKoo Cat#: 530995
Name: AX-024 HCl
CAS#: 1704801-24-0
Chemical Formula: C21H23ClFNO2
Exact Mass: 375.1401
Molecular Weight: 375.8684
Elemental Analysis: C, 67.11; H, 6.17; Cl, 9.43; F, 5.05; N, 3.73; O, 8.51


Synonym: AX-024; AX 024; AX024 HCl; AX-024 hydrochloride

IUPAC/Chemical Name: 1-((4-(4-Fluorophenyl)-6-methoxy-2H-chromen-3-yl)methyl)pyrrolidine hydrochloride

InChi Key: DGBCIMPGYRVTPD-UHFFFAOYSA-N

InChi Code: InChI=1S/C21H22FNO2.ClH/c1-24-18-8-9-20-19(12-18)21(15-4-6-17(22)7-5-15)16(14-25-20)13-23-10-2-3-11-23;/h4-9,12H,2-3,10-11,13-14H2,1H3;1H

SMILES Code: COC1=CC(C(C2=CC=C(F)C=C2)=C(CN3CCCC3)CO4)=C4C=C1.[H]Cl


Technical Data

Appearance:
Solid powder

Purity:
>98% (or refer to the Certificate of Analysis)

Shipping Condition:
Shipped under ambient temperature as non-hazardous chemical. This product is stable enough for a few weeks during ordinary shipping and time spent in Customs.

Storage Condition:
Dry, dark and at 0 - 4 C for short term (days to weeks) or -20 C for long term (months to years).

Solubility:
Soluble in DMSO

Shelf Life:
>2 years if stored properly

Drug Formulation:
This drug may be formulated in DMSO

Stock Solution Storage:
0 - 4 C for short term (days to weeks), or -20 C for long term (months).

Harmonized System Code:
293490


References

1: Borroto A, Reyes-Garau D, Jiménez MA, Carrasco E, Moreno B, Martínez-Pasamar
S, Cortés JR, Perona A, Abia D, Blanco S, Fuentes M, Arellano I, Lobo J,
Heidarieh H, Rueda J, Esteve P, Cibrián D, Martinez-Riaño A, Mendoza P, Prieto C,
Calleja E, Oeste CL, Orfao A, Fresno M, Sánchez-Madrid F, Alcamí A, Bovolenta P,
Martín P, Villoslada P, Morreale A, Messeguer A, Alarcon B. First-in-class
inhibitor of the T cell receptor for the treatment of autoimmune diseases. Sci
Transl Med. 2016 Dec 21;8(370):370ra184. doi: 10.1126/scitranslmed.aaf2140.
PubMed PMID: 28003549.