IOX4
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    WARNING: This product is for research use only, not for human or veterinary use.

MedKoo CAT#: 530994

CAS#: 1154097-71-8

Description: OX4 is a potent inhibitor of PHD2 (IC50 = 1.6 nM). IOX4 induces HIFα in cells and in wildtype mice with marked induction in the brain tissue, revealing that it is useful for studies aimed at validating the upregulation of HIF for treatment of cerebral diseases including stroke.


Price and Availability

Size
Price

25mg
USD 190
500mg
USD 1650
Size
Price

100mg
USD 650
1g
USD 2750
Size
Price

200mg
USD 950
5g
USD 6950

IOX4, purity > 98%, is in stock. Current shipping out time is about 2 weeks after order is received. CoA, QC data and MSDS documents are available in one week after order is received.


Chemical Structure

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Theoretical Analysis

MedKoo Cat#: 530994
Name: IOX4
CAS#: 1154097-71-8
Chemical Formula: C15H16N6O3
Exact Mass: 328.1284
Molecular Weight: 328.332
Elemental Analysis: C, 54.87; H, 4.91; N, 25.60; O, 14.62


Synonym: IOX4; IOX-4; IOX 4.

IUPAC/Chemical Name: tert-butyl 6-(5-oxo-4-(1H-1,2,3-triazol-1-yl)-2,5-dihydro-1H-pyrazol-1-yl)nicotinate

InChi Key: HWQQDVNGHZIALS-UHFFFAOYSA-N

InChi Code: InChI=1S/C15H16N6O3/c1-15(2,3)24-14(23)10-4-5-12(16-8-10)21-13(22)11(9-18-21)20-7-6-17-19-20/h4-9,18H,1-3H3

SMILES Code: CC(C)(C)OC(C1=CN=C(N2NC=C(N3C=CN=N3)C2=O)C=C1)=O


Technical Data

Appearance:
Solid powder

Purity:
>98% (or refer to the Certificate of Analysis)

Shipping Condition:
Shipped under ambient temperature as non-hazardous chemical. This product is stable enough for a few weeks during ordinary shipping and time spent in Customs.

Storage Condition:
Dry, dark and at 0 - 4 C for short term (days to weeks) or -20 C for long term (months to years).

Solubility:
Soluble in DMSO

Shelf Life:
>2 years if stored properly

Drug Formulation:
This drug may be formulated in DMSO

Stock Solution Storage:
0 - 4 C for short term (days to weeks), or -20 C for long term (months).

Harmonized System Code:
293490


References

1: Chan MC, Atasoylu O, Hodson E, Tumber A, Leung IK, Chowdhury R, Gómez-Pérez V,
Demetriades M, Rydzik AM, Holt-Martyn J, Tian YM, Bishop T, Claridge TD, Kawamura
A, Pugh CW, Ratcliffe PJ, Schofield CJ. Potent and Selective Triazole-Based
Inhibitors of the Hypoxia-Inducible Factor Prolyl-Hydroxylases with Activity in
the Murine Brain. PLoS One. 2015 Jul 6;10(7):e0132004. doi:
10.1371/journal.pone.0132004. eCollection 2015. PubMed PMID: 26147748; PubMed
Central PMCID: PMC4492579.