PSMA-11 TFA

    WARNING: This product is for research use only, not for human or veterinary use.

MedKoo CAT#: 407850

CAS#: 2412149-32-5 (TFA)

Description: Gozetotide, also known as PSMA-11, DKFZ-​PSMA-​11, HBED-CC-PSMA or Psma-hbed-CC, is a ligand to make gallium Ga 68-labeled PSMA-11, which has potential use as a tracer for PSMA-expressing tumors during positron emission tomography (PET). Upon intravenous administration of gallium Ga 68-labeled PSMA-11, the Glu-urea-Lys(Ahx) moiety targets and binds to PSMA-expressing tumor cells. Upon internalization, PSMA-expressing tumor cells can be detected during PET imaging. PSMA, a tumor-associated antigen and type II transmembrane protein, is expressed on the membrane of prostatic epithelial cells and overexpressed on prostate tumor cells

Chemical Structure

img
PSMA-11 TFA
CAS# 2412149-32-5 (TFA)
Instruction

Theoretical Analysis

MedKoo Cat#: 407850
Name: PSMA-11 TFA
CAS#: 2412149-32-5 (TFA)
Chemical Formula: C48H64F6N6O21
Exact Mass: 946.42
Molecular Weight: 1,175.051
Elemental Analysis: C, 49.06; H, 5.49; F, 9.70; N, 7.15; O, 28.59

Price and Availability

This product is not in stock, which may be available by custom synthesis. For cost-effective reason, minimum order is 1g (price is usually high, lead time is 2~3 months, depending on the technical challenge). Quote less than 1g will not be provided. To request quote, please email to sales @medkoo.com or click below button.
Note: Price will be listed if it is available in the future.

Request quote for custom synthesis

Related CAS #: 2412149-32-5 (TFA)   1366302-52-4 (free base)   PSMA-11 HCl    

Synonym: DKFZ-​PSMA-​11; Psma-hbed-CC; PSMA-11; PSMA11; PSMA 11; HBED-CC-PSMA; PSMA-11 TFA; Psma-hbed-CC

IUPAC/Chemical Name: (3S,7S)-22-(3-(((2-((5-(2-carboxyethyl)-2-hydroxybenzyl)(carboxymethyl)amino)ethyl)(carboxymethyl)amino)methyl)-4-hydroxyphenyl)-5,13,20-trioxo-4,6,12,19-tetraazadocosane-1,3,7-tricarboxylic acid compound with 2,2,2-trifluoroacetic acid (1:2)

InChi Key: AQFVQZGRRYAIHI-VIZPSHFESA-N

InChi Code: InChI=1S/C44H62N6O17.2C2HF3O2/c51-34-13-8-28(22-30(34)24-49(26-40(59)60)20-21-50(27-41(61)62)25-31-23-29(9-14-35(31)52)11-16-38(55)56)10-15-37(54)46-18-4-1-2-7-36(53)45-19-5-3-6-32(42(63)64)47-44(67)48-33(43(65)66)12-17-39(57)58;2*3-2(4,5)1(6)7/h8-9,13-14,22-23,32-33,51-52H,1-7,10-12,15-21,24-27H2,(H,45,53)(H,46,54)(H,55,56)(H,57,58)(H,59,60)(H,61,62)(H,63,64)(H,65,66)(H2,47,48,67);2*(H,6,7)/t32-,33-;;/m0../s1

SMILES Code: O=C(O)CC[C@H](NC(N[C@@H](CCCCNC(CCCCCNC(CCC1=CC=C(C(CN(CC(O)=O)CCN(CC(O)=O)CC2=CC(CCC(O)=O)=CC=C2O)=C1)O)=O)=O)C(O)=O)=O)C(O)=O.O=C(O)C(F)(F)F.O=C(O)C(F)(F)F

Appearance: Solid powder

Purity: >98% (or refer to the Certificate of Analysis)

Shipping Condition: Shipped under ambient temperature as non-hazardous chemical. This product is stable enough for a few weeks during ordinary shipping and time spent in Customs.

Storage Condition: Dry, dark and at 0 - 4 C for short term (days to weeks) or -20 C for long term (months to years).

Solubility: Soluble in water

Shelf Life: >2 years if stored properly

Drug Formulation: This drug may be formulated in water

Stock Solution Storage: 0 - 4 C for short term (days to weeks), or -20 C for long term (months).

HS Tariff Code: 2934.99.9001

More Info:

Biological target:
In vitro activity:
In vivo activity:

Solubility Data

Solvent Max Conc. mg/mL Max Conc. mM
Solubility
Water (To be determined) 0.0 0.00

Preparing Stock Solutions

The following data is based on the product molecular weight 1,175.05 Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.

Recalculate based on batch purity %
Concentration / Solvent Volume / Mass 1 mg 5 mg 10 mg
1 mM 1.15 mL 5.76 mL 11.51 mL
5 mM 0.23 mL 1.15 mL 2.3 mL
10 mM 0.12 mL 0.58 mL 1.15 mL
50 mM 0.02 mL 0.12 mL 0.23 mL
Formulation protocol:
In vitro protocol:
In vivo protocol:

Molarity Calculator

Calculate the mass, volume, or concentration required for a solution.
=
x
x
g/mol

*When preparing stock solutions always use the batch-specific molecular weight of the product found on the vial label and SDS / CoA (available online).

Reconstitution Calculator

The reconstitution calculator allows you to quickly calculate the volume of a reagent to reconstitute your vial. Simply enter the mass of reagent and the target concentration and the calculator will determine the rest.

=
÷

Dilution Calculator

Calculate the dilution required to prepare a stock solution.
x
=
x

1: Ghezzo S, Mapelli P, Bezzi C, Samanes Gajate AM, Brembilla G, Gotuzzo I, Russo T, Preza E, Cucchiara V, Ahmed N, Neri I, Mongardi S, Freschi M, Briganti A, De Cobelli F, Gianolli L, Scifo P, Picchio M. Role of [68Ga]Ga- PSMA-11 PET radiomics to predict post-surgical ISUP grade in primary prostate cancer. Eur J Nucl Med Mol Imaging. 2023 Mar 18. doi: 10.1007/s00259-023-06187-3. Epub ahead of print. PMID: 36933074.


2: Tang CYL, Lim GKY, Chua WM, Ng CWQ, Koo SX, Goh CX, Thang SP, Zaheer S, Lam WWC, Huang HL. Optimization of Bayesian penalized likelihood reconstruction for 68Ga-prostate-specific membrane antigen-11 PET/computed tomography. Nucl Med Commun. 2023 Mar 15. doi: 10.1097/MNM.0000000000001687. Epub ahead of print. PMID: 36917459.


3: Burgard C, Hoffmann MA, Frei M, Buchholz HG, Khreish F, Marlowe RJ, Schreckenberger M, Ezziddin S, Rosar F. Detection Efficacy of 68Ga- PSMA-11 PET/CT in Biochemical Recurrence of Prostate Cancer with Very Low PSA Levels: A 7-Year, Two-Center "Real-World" Experience. Cancers (Basel). 2023 Feb 21;15(5):1376. doi: 10.3390/cancers15051376. PMID: 36900169; PMCID: PMC10000220.


4: Bauckneht M, Miceli A, Signori A, Albano D, Capitanio S, Piva R, Laudicella R, Franchini A, D'Amico F, Riondato M, Chiola S, Marini C, Fornarini G, Scarale A, Muni A, Bertagna F, Burger IA, Sambuceti G, Morbelli S. Combined forced diuresis and late acquisition on [68Ga]Ga-PSMA-11 PET/CT for biochemical recurrent prostate cancer: a clinical practice-oriented study. Eur Radiol. 2023 Mar 9. doi: 10.1007/s00330-023-09516-0. Epub ahead of print. PMID: 36892650.


5: Donswijk ML, Piek MW, Cheung Z, Wondergem M, Stokkel MPM, de Boer JP, van der Ploeg IMC. Incidence of PSMA PET thyroid incidentaloma depends on analysis method and tracer. Eur Radiol. 2023 Mar 9. doi: 10.1007/s00330-023-09492-5. Epub ahead of print. PMID: 36892644.


6: Chattopadhyay S, Ash S, Mahesh DG, Barua L, Mitra A, Das SS, Singha S, Nayer MA, Madhusmita, Kumar U, Sinha S. Preparation of [68Ga]Ga-Chloride from 68Zn solid target for the synthesis of pharmaceutical grade [68Ga]Ga-PSMA-11 and [68Ga]Ga-DOTA-TATE. Appl Radiat Isot. 2023 May;195:110744. doi: 10.1016/j.apradiso.2023.110744. Epub 2023 Feb 26. PMID: 36867922.


7: Kim M, Seifert R, Fragemann J, Kersting D, Murray J, Jonske F, Pomykala KL, Egger J, Fendler WP, Herrmann K, Kleesiek J. Evaluation of thresholding methods for the quantification of [68Ga]Ga-PSMA-11 PET molecular tumor volume and their effect on survival prediction in patients with advanced prostate cancer undergoing [177Lu]Lu-PSMA-617 radioligand therapy. Eur J Nucl Med Mol Imaging. 2023 Mar 2. doi: 10.1007/s00259-023-06163-x. Epub ahead of print. PMID: 36859618.


8: Muraglia L, Mattana F, Travaini LL, Musi G, Bertani E, Renne G, Pisa E, Ferrari ME, Fumagalli Romario U, De Cobelli O, Fusco N, Ceci F. First Live- Experience Session with PET/CT Specimen Imager: A Pilot Analysis in Prostate Cancer and Neuroendocrine Tumor. Biomedicines. 2023 Feb 20;11(2):645. doi: 10.3390/biomedicines11020645. PMID: 36831181; PMCID: PMC9953571.


9: Vetrone L, Cuzzani G, Mei R, Zanoni L, Bertaccini A, Bianchi L, Castellucci P, Gaudiano C, Cappelli A, Giunchi F, Fanti S. Case report: PSMA PET/CT addresses the correct diagnosis in a patient with metastatic prostate cancer despite negative core biopsies and mpMRI. A diagnostic challenge. Front Oncol. 2023 Feb 7;13:1101221. doi: 10.3389/fonc.2023.1101221. PMID: 36824128; PMCID: PMC9941543.


10: Wang B, Deng Y, Xu Q, Gao J, Shen H, He X, Ding Q, Wang F, Guo H. Exploration of 68Ga-labelled prostate-specific membrane antigen-11 PET/CT parameters for identifying PBRM1 status in primary clear cell renal cell carcinoma. Clin Radiol. 2023 Feb 1:S0009-9260(23)00025-9. doi: 10.1016/j.crad.2023.01.003. Epub ahead of print. PMID: 36805287.


11: Kim MH, Lee K, Oh K, Kim CH, Kil HS, Lee YJ, Lee KC, Chi DY. Evaluation of PSMA target diagnostic PET tracers for therapeutic monitoring of [177Lu]ludotadipep of prostate cancer: Screening of PSMA target efficiency and biodistribution using [18F]DCFPyL and [68Ga]PSMA-11. Biochem Biophys Res Commun. 2023 Apr 9;651:107-113. doi: 10.1016/j.bbrc.2023.02.003. Epub 2023 Feb 11. PMID: 36801611.


12: Liu Y, Niu S, Luan X, Zhang X, Liu J, Zhang J, Wang R, Xu B, Zhang X. Can 18F-PSMA-7Q PET/CT replace prostate biopsy for the diagnosis of prostate cancer?-A single-center retrospective study. Transl Androl Urol. 2023 Jan 30;12(1):83-89. doi: 10.21037/tau-22-813. Epub 2023 Jan 12. PMID: 36760865; PMCID: PMC9906103.


13: Sonni I, Dal Pra A, O'Connell DP, Ells Z, Benz M, Nguyen K, Yoon SM, Deng J, Smith C, Grogan T, Nickols NG, Cao M, Kishan AU, Calais J. PSMA PET/CT-based Atlas for Prostatic Bed Recurrence after Radical Prostatectomy: Clinical Implications for Salvage Radiation Therapy Contouring Guidelines. J Nucl Med. 2023 Feb 9:jnumed.122.265025. doi: 10.2967/jnumed.122.265025. Epub ahead of print. PMID: 36759200.


14: Arslan E, Ergül N, Beyhan E, Erol Fenercioglu Ö, Sahin R, Cin M, Battal Havare S, Can Trabulus FD, Mermut Ö, Akbas S, Fikret Çermik T. The roles of 68 Ga-PSMA PET/CT and 18 F-FDG PET/CT imaging in patients with triple-negative breast cancer and the association of tissue PSMA and claudin 1, 4, and 7 levels with PET findings. Nucl Med Commun. 2023 Apr 1;44(4):284-290. doi: 10.1097/MNM.0000000000001663. Epub 2023 Feb 9. PMID: 36756767.


15: Afshar-Oromieh A, Eiber M, Fendler W, Schmidt M, Rahbar K, Ahmadzadehfar H, Umutlu L, Hadaschik B, Hakenberg OW, Fornara P, Kurth J, Neels O, Wester HJ, Schwaiger M, Kopka K, Haberkorn U, Herrmann K, Krause BJ; Deutsche Gesellschaft für Urologie e. V. (DGU); Deutsche Röntgengesellschaft e. V. (DRG). DGN- Handlungsempfehlung (S1-Leitlinie) – PSMA-Liganden-PET/CT in der Diagnostik des Prostatakarzinoms – Stand: 01/2022 – AWMF-Registernummer: 031-055 [Procedure Guideline for Prostate Cancer Imaging with PSMA-ligand PET/CT]. Nuklearmedizin. 2023 Feb;62(1):5-19. German. doi: 10.1055/a-1984-8167. Epub 2023 Feb 6. PMID: 36746147.


16: Grahovac M, Spielvogel CP, Krajnc D, Ecsedi B, Traub-Weidinger T, Rasul S, Kluge K, Zhao M, Li X, Hacker M, Haug A, Papp L. Machine learning predictive performance evaluation of conventional and fuzzy radiomics in clinical cancer imaging cohorts. Eur J Nucl Med Mol Imaging. 2023 Feb 4. doi: 10.1007/s00259-023-06127-1. Epub ahead of print. PMID: 36738311.


17: Urso L, Rocca GC, Uccelli L, Ippolito C, Bartolomei M. 18 F-Choline Versus 68 Ga-PSMA-11 PET/CT Imaging Comparison in Incidental Clear Cell Renal Cell Carcinoma. Clin Nucl Med. 2023 Apr 1;48(4):e178-e180. doi: 10.1097/RLU.0000000000004515. Epub 2023 Feb 1. PMID: 36728284.


18: Aggarwal P, Kaur K, Sood A, Periasamy K, Nagi S, Mittal BR. Increased PSMA Expression in 177Lu-PSMA-617 Scan in Metastatic Castrate-Resistant Prostate Cancer Patient Treated With PSMA Radioligand Therapy and Enzalutamide: A Potential Game-Changer. Clin Nucl Med. 2023 Jan 12. doi: 10.1097/RLU.0000000000004529. Epub ahead of print. PMID: 36728226.


19: Adediran OA, Lawal IO, Muzahir S, Bhave MA, Friend S, Fielder B, Meisel J, Torres MA, Styblo TM, Graham C, Holbrook A, Kalinsky K, Crowe RJ, Ulaner GA, Schuster DM. A Discordant Pattern of Uptake on 68 Ga-PSMA PET/CT Versus 18 F-Fluciclovine PET/CT in Radiation-Induced Hepatitis : Implications for Early Postradiotherapy Imaging-Based Response Assessment. Clin Nucl Med. 2023 Apr 1;48(4):e202-e203. doi: 10.1097/RLU.0000000000004565. Epub 2023 Jan 14. PMID: 36728139.


20: Riaz S, Priftakis D, Afaq A, Kayani I, Bomanji J. 68 Ga-PSMA-Avid Intranasal Solitary Fibrous Tumor. Clin Nucl Med. 2023 Apr 1;48(4):e184-e185. doi: 10.1097/RLU.0000000000004572. Epub 2023 Jan 20. PMID: 36727873.