VU6010608

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MedKoo CAT#: 530983

CAS#: Unknown

Description: VU6010608 is a potent mGlu7 NAM. VU6010608 showed excellent CNS penetration (Kp 1.9−5.8 and Kp,uu 0.4−1.4). VU6010608 emerged with robust efficacy in blocking high frequency stimulated long-term potentiation in electrophysiology studies. VU6010608 displayed low predicted hepatic clearance in rat (CLhep = 9.5 mL/min/kg) and moderate in mouse (CLhep = 48.5 mL/min/kg).


Price and Availability

Size Price Shipping out time Quantity
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Pricing updated 2020-10-29. Prices are subject to change without notice.

VU6010608 is not in stock, may be available through custom synthesis. For cost-effective reason, minimum 1 gram order is requested. The product will be characterized by NMR, HPLC and MS analysis. Purity (HPLC) is usually >98%. CoA, QC data, MSDS will be provided when product is successfully made. The estimated lead time is 2-3 months. Please send email to sales@medkoo.com to inquire quote.


Chemical Structure

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Theoretical Analysis

MedKoo Cat#: 530983
Name: VU6010608
CAS#: Unknown
Chemical Formula: C18H15F3N4O4
Exact Mass: 408.1045
Molecular Weight: 408.3372
Elemental Analysis: C, 52.95; H, 3.70; F, 13.96; N, 13.72; O, 15.67


Synonym: VU6010608; VU-6010608; VU 6010608.

IUPAC/Chemical Name: N-(2-(1H-1,2,4-triazol-1-yl)-5-(trifluoromethoxy)phenyl)-3,4-dimethoxybenzamide

InChi Key: YCDOKDADFOBKIL-UHFFFAOYSA-N

InChi Code: InChI=1S/C18H15F3N4O4/c1-27-15-6-3-11(7-16(15)28-2)17(26)24-13-8-12(29-18(19,20)21)4-5-14(13)25-10-22-9-23-25/h3-10H,1-2H3,(H,24,26)

SMILES Code: O=C(NC1=CC(OC(F)(F)F)=CC=C1N2N=CN=C2)C3=CC=C(OC)C(OC)=C3


Technical Data

Appearance:
Solid powder

Purity:
>98% (or refer to the Certificate of Analysis)

Shipping Condition:
Shipped under ambient temperature as non-hazardous chemical. This product is stable enough for a few weeks during ordinary shipping and time spent in Customs.

Storage Condition:
Dry, dark and at 0 - 4 C for short term (days to weeks) or -20 C for long term (months to years).

Solubility:
Soluble in DMSO

Shelf Life:
>2 years if stored properly

Drug Formulation:
This drug may be formulated in DMSO

Stock Solution Storage:
0 - 4 C for short term (days to weeks), or -20 C for long term (months).

HS Tariff Code:
2934.99.9001


References

VU6010608, a Novel mGlu7 NAM from a Series of N-(2-(1H-1,2,4-Triazol-1-yl)-5-(trifluoromethoxy)phenyl)benzamides
Carson W. Reed, Kevin M. McGowan, Paul K. Spearing, Branden J. Stansley, Hanna F. Roenfanz, Darren W. Engers, Alice L. Rodriguez, Eileen M. Engelberg, Vincent B. Luscombe, Matthew T. Loch, Daniel H. Remke, Jerri M. Rook, Anna L. Blobaum, P. Jeffrey Conn, Colleen M. Niswender, and Craig W. Lindsley
Publication Date (Web): November 8, 2017 (Letter)
DOI: 10.1021/acsmedchemlett.7b00429