WARNING: This product is for research use only, not for human or veterinary use.
MedKoo CAT#: 329882
CAS#: 475650-36-3 (free)
Description: Inarigivir, also known as ORI-9020 and SB-9000, is a novel dinucleotide, evaluated in transgenic mice expressing hepatitis B virus (HBV), significantly reduced liver HBV DNA (P </= 0.001). Levels of HBeAg and HBsAg in serum and of HBcAg in liver were not affected by treatment. A minimal effective dosage was determined to be between 1.6 and 0.5 mg/kg of body weight/day, which was similar to that observed for adefovir dipivoxil.
MedKoo Cat#: 329882
Name: Inarigivir
CAS#: 475650-36-3 (free)
Chemical Formula: C20H26N7O10PS
Exact Mass: 587.1199
Molecular Weight: 587.5008
Elemental Analysis: C, 40.89; H, 4.46; N, 16.69; O, 27.23; P, 5.27; S, 5.46
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Related CAS #: 942123-43-5 (soproxil) 475650-36-3 (free) 2172788-92-8 (ammonium)
Synonym: Inarigivir; ORI-9020; ORI 9020; ORI9020; SB-40; SB-9000; SB9000, SB-9000.
IUPAC/Chemical Name: O-(((2R,3S,5R)-5-(6-amino-9H-purin-9-yl)-3-hydroxytetrahydrofuran-2-yl)methyl) O-((2R,3R,4R,5R)-5-(2,4-dioxo-3,4-dihydropyrimidin-1(2H)-yl)-2-(hydroxymethyl)-4-methoxytetrahydrofuran-3-yl) S-hydrogen phosphorothioate
InChi Key: LYMICVBGNUEHGE-FUQPUAIBSA-N
InChi Code: InChI=1S/C20H26N7O10PS/c1-33-16-15(10(5-28)36-19(16)26-3-2-12(30)25-20(26)31)37-38(32,39)34-6-11-9(29)4-13(35-11)27-8-24-14-17(21)22-7-23-18(14)27/h2-3,7-11,13,15-16,19,28-29H,4-6H2,1H3,(H,32,39)(H2,21,22,23)(H,25,30,31)/t9-,10+,11+,13+,15+,16+,19+,38?/m0/s1
SMILES Code: O=P(OC[C@H]1O[C@@H](N2C=NC3=C(N)N=CN=C23)C[C@@H]1O)(S)O[C@@H]4[C@@H](CO)O[C@@H](N(C(N5)=O)C=CC5=O)[C@@H]4OC
Appearance: Solid powder
Purity: >98% (or refer to the Certificate of Analysis)
Shipping Condition: Shipped under ambient temperature as non-hazardous chemical. This product is stable enough for a few weeks during ordinary shipping and time spent in Customs.
Storage Condition: Dry, dark and at 0 - 4 C for short term (days to weeks) or -20 C for long term (months to years).
Solubility: Soluble in DMSO
Shelf Life: >2 years if stored properly
Drug Formulation: This drug may be formulated in DMSO
Stock Solution Storage: 0 - 4 C for short term (days to weeks), or -20 C for long term (months).
HS Tariff Code: 2934.99.9001
The following data is based on the product molecular weight 587.5008 Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.
| Concentration / Solvent Volume / Mass | 1 mg | 5 mg | 10 mg |
|---|---|---|---|
| 1 mM | 1.15 mL | 5.76 mL | 11.51 mL |
| 5 mM | 0.23 mL | 1.15 mL | 2.3 mL |
| 10 mM | 0.12 mL | 0.58 mL | 1.15 mL |
| 50 mM | 0.02 mL | 0.12 mL | 0.23 mL |
1: Iyer RP, Roland A, Jin Y, Mounir S, Korba B, Julander JG, Morrey JD.
Anti-hepatitis B virus activity of ORI-9020, a novel phosphorothioate
dinucleotide, in a transgenic mouse model. Antimicrob Agents Chemother. 2004
Jun;48(6):2318-20. PubMed PMID: 15155244; PubMed Central PMCID: PMC415565.
2: Iyer RP, Jin Y, Roland A, Morrey JD, Mounir S, Korba B. Phosphorothioate di-
and trinucleotides as a novel class of anti-hepatitis B virus agents. Antimicrob
Agents Chemother. 2004 Jun;48(6):2199-205. PubMed PMID: 15155222; PubMed Central
PMCID: PMC415564.
