WARNING: This product is for research use only, not for human or veterinary use.
MedKoo CAT#: 561555
CAS#: 1918238-72-8
Description: JAK3i is a selective covalent inhibitor of JAK3 kinase activity. It reveals two distinct temporal waves of STAT5 phosphorylation and more potently targets the second wave, which is required for cell cycle progression and T cell proliferation.
MedKoo Cat#: 561555
Name: JAK3i
CAS#: 1918238-72-8
Chemical Formula: C18H15FN4O3
Exact Mass: 354.1128
Molecular Weight: 354.34
Elemental Analysis: C, 61.01; H, 4.27; F, 5.36; N, 15.81; O, 13.55
JAK3i is not in stock, may be available through custom synthesis. For cost-effective reason, minimum 1 gram order is requested. The product will be characterized by NMR, HPLC and MS analysis. Purity (HPLC) is usually >98%. CoA, QC data, MSDS will be provided when product is successfully made. The estimated lead time is 2-3 months. Please send email to sales@medkoo.com to inquire quote.
Synonym: JAK3i; JAK 3i; JAK-3i;
IUPAC/Chemical Name: Ethyl 4-(5-acrylamido-2-fluorophenyl)-7H-pyrrolo[2,3-d]pyrimidine-5-carboxylate
InChi Key: KNLROUBMVYVLGX-UHFFFAOYSA-N
InChi Code: InChI=1S/C18H15FN4O3/c1-3-14(24)23-10-5-6-13(19)11(7-10)16-15-12(18(25)26-4-2)8-20-17(15)22-9-21-16/h3,5-9H,1,4H2,2H3,(H,23,24)(H,20,21,22)
SMILES Code: O=C(C1=CNC2=NC=NC(C3=CC(NC(C=C)=O)=CC=C3F)=C21)OCC
The following data is based on the product molecular weight 354.34 Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.
Concentration / Solvent Volume / Mass | 1 mg | 5 mg | 10 mg |
---|---|---|---|
1 mM | 1.15 mL | 5.76 mL | 11.51 mL |
5 mM | 0.23 mL | 1.15 mL | 2.3 mL |
10 mM | 0.12 mL | 0.58 mL | 1.15 mL |
50 mM | 0.02 mL | 0.12 mL | 0.23 mL |
1: Smith GA, Uchida K, Weiss A, Taunton J. Essential biphasic role for JAK3 catalytic activity in IL-2 receptor signaling. Nat Chem Biol. 2016 May;12(5):373-9. doi: 10.1038/nchembio.2056. Epub 2016 Mar 28. PubMed PMID: 27018889; PubMed Central PMCID: PMC4837022.