A-943931 HCL

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MedKoo CAT#: 581019

CAS#: 1227675-50-4 (HCL)

Description: A-943931 is Potent and selective H4 antagonist. Potent and selective histamine H4 receptor antagonist (pKi values are 7.15 and 8.12 at human and rat receptors respectively). Blocks inflammation in a peritonitis mouse model and displays efficacy in inflammatory pain and neuropathic pain models. Shows anti-inflammatory and analgesic effects in vivo. Orally active.

Price and Availability

Size Price Shipping out time Quantity
10mg USD 330 2 Weeks
50mg USD 1080 2 Weeks
Inquire bulk and customized quantity

Pricing updated 2020-04-02. Prices are subject to change without notice.

A-943931 HCL,, purity > 98%, is in stock. Current shipping out time is about 2 weeks after order is received. CoA, QC data and MSDS documents are available in one week after order is received.

Chemical Structure


Theoretical Analysis

MedKoo Cat#: 581019
Name: A-943931 HCL
CAS#: 1227675-50-4 (HCL)
Chemical Formula: C17H23Cl2N5
Exact Mass: 295.1797
Molecular Weight: 368.31
Elemental Analysis: C, 55.44; H, 6.29; Cl, 19.25; N, 19.02

Related CAS #: 1227675-50-4 (HCL); 1227675-50-4  

Synonym: A-943931 Dihydrochloride; A-943931 HCL; A 943931 HCI; A-943931(HCL); A-943931-HCI; A-943931Dihydrochloride; A 943931 Dihydrochloride; A-943931-Dihydrochloride, A943931Dihydrochloride.

IUPAC/Chemical Name: (R)-4-(3-aminopyrrolidin-1-yl)-6,7-dihydro-5H-benzo[6,7]cyclohepta[1,2-d]pyrimidin-2-amine dihydrochloride


InChi Code: InChI=1S/C17H21N5.2ClH/c18-12-8-9-22(10-12)16-14-7-3-5-11-4-1-2-6-13(11)15(14)20-17(19)21-16;;/h1-2,4,6,12H,3,5,7-10,18H2,(H2,19,20,21);2*1H/t12-;;/m1../s1

SMILES Code: NC1=NC(N2C[C@H](N)CC2)=C(CCCC3=CC=CC=C34)C4=N1.[H]Cl.[H]Cl

Technical Data

Solid powder

>98% (or refer to the Certificate of Analysis)

Shipping Condition:
Shipped under ambient temperature as non-hazardous chemical. This product is stable enough for a few weeks during ordinary shipping and time spent in Customs.

Storage Condition:
Dry, dark and at 0 - 4 C for short term (days to weeks) or -20 C for long term (months to years).

Soluble in DMSO

Shelf Life:
>2 years if stored properly

Drug Formulation:
This drug may be formulated in DMSO

Stock Solution Storage:
0 - 4 C for short term (days to weeks), or -20 C for long term (months).

HS Tariff Code:


1: Cowart MD, Altenbach RJ, Liu H, Hsieh GC, Drizin I, Milicic I, Miller TR,
Witte DG, Wishart N, Fix-Stenzel SR, McPherson MJ, Adair RM, Wetter JM,
Bettencourt BM, Marsh KC, Sullivan JP, Honore P, Esbenshade TA, Brioni JD.
Rotationally constrained 2,4-diamino-5,6-disubstituted pyrimidines: a new class
of histamine H4 receptor antagonists with improved druglikeness and in vivo
efficacy in pain and inflammation models. J Med Chem. 2008 Oct 23;51(20):6547-57.
doi: 10.1021/jm800670r. Epub 2008 Sep 26. PubMed PMID: 18817367.