E1R

    WARNING: This product is for research use only, not for human or veterinary use.

MedKoo CAT#: 561517

CAS#: 1301211-78-8

Description: E1R is a novel positive allosteric modulator of sigma-1 receptors. E1R is a novel 4,5-disubstituted derivative of piracetam that enhances cognition and demonstrates efficacy against scopolamine-induced cholinergic dysfunction in mice.

Chemical Structure

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E1R
CAS# 1301211-78-8
Instruction

Theoretical Analysis

MedKoo Cat#: 561517
Name: E1R
CAS#: 1301211-78-8
Chemical Formula: C13H16N2O2
Exact Mass: 232.12
Molecular Weight: 232.280
Elemental Analysis: C, 67.22; H, 6.94; N, 12.06; O, 13.78

Price and Availability

This product is not in stock, which may be available by custom synthesis. For cost-effective reason, minimum order is 1g (price is usually high, lead time is 2~3 months, depending on the technical challenge). Quote less than 1g will not be provided. To request quote, please email to sales @medkoo.com or click below button.
Note: Price will be listed if it is available in the future.

Request quote for custom synthesis

Synonym: E1R; E-1-R; E 1 R;

IUPAC/Chemical Name: (4R,5S)-2-(5-methyl-2-oxo-4-phenyl-pyrrolidin-1-yl)-acetamide

InChi Key: ZTGRWYMPQCQTHD-ONGXEEELSA-N

InChi Code: InChI=1S/C13H16N2O2/c1-9-11(10-5-3-2-4-6-10)7-13(17)15(9)8-12(14)16/h2-6,9,11H,7-8H2,1H3,(H2,14,16)/t9-,11-/m0/s1

SMILES Code: O=C(N)CN1C(C[C@H](C2=CC=CC=C2)[C@@H]1C)=O

Appearance: Solid powder

Purity: >98% (or refer to the Certificate of Analysis)

Shipping Condition: Shipped under ambient temperature as non-hazardous chemical. This product is stable enough for a few weeks during ordinary shipping and time spent in Customs.

Storage Condition: Dry, dark and at 0 - 4 C for short term (days to weeks) or -20 C for long term (months to years).

Solubility: Soluble in DMSO

Shelf Life: >2 years if stored properly

Drug Formulation: This drug may be formulated in DMSO

Stock Solution Storage: 0 - 4 C for short term (days to weeks), or -20 C for long term (months).

HS Tariff Code: 2934.99.9001

More Info:

Biological target:
In vitro activity:
In vivo activity:

Preparing Stock Solutions

The following data is based on the product molecular weight 232.28 Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.

Recalculate based on batch purity %
Concentration / Solvent Volume / Mass 1 mg 5 mg 10 mg
1 mM 1.15 mL 5.76 mL 11.51 mL
5 mM 0.23 mL 1.15 mL 2.3 mL
10 mM 0.12 mL 0.58 mL 1.15 mL
50 mM 0.02 mL 0.12 mL 0.23 mL
Formulation protocol:
In vitro protocol:
In vivo protocol:

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1: Saulite L, Vavers E, Zvejniece L, Dambrova M, Riekstina U. The Differentiation of Skin Mesenchymal Stem Cells Towards a Schwann Cell Phenotype: Impact of Sigma-1 Receptor Activation. Mol Neurobiol. 2017 Apr 28. doi: 10.1007/s12035-017-0511-9. [Epub ahead of print] PubMed PMID: 28455697.

2: Vavers E, Svalbe B, Lauberte L, Stonans I, Misane I, Dambrova M, Zvejniece L. The activity of selective sigma-1 receptor ligands in seizure models in vivo. Behav Brain Res. 2017 Jun 15;328:13-18. doi: 10.1016/j.bbr.2017.04.008. Epub 2017 Apr 4. PubMed PMID: 28389336.

3: Zvejniece L, Vavers E, Svalbe B, Vilskersts R, Domracheva I, Vorona M, Veinberg G, Misane I, Stonans I, Kalvinsh I, Dambrova M. The cognition-enhancing activity of E1R, a novel positive allosteric modulator of sigma-1 receptors. Br J Pharmacol. 2014 Feb;171(3):761-71. doi: 10.1111/bph.12506. PubMed PMID: 24490863; PubMed Central PMCID: PMC3969087.