Maritinone

    WARNING: This product is for research use only, not for human or veterinary use.

MedKoo CAT#: 561490

CAS#: 33927-59-2

Description: Maritinone is a novel anti-tuberculosis (anti-TB) agent. It possess an interesting potential for development as a new drug against Mycobacterium tuberculosis, mainly resistant profile strains.


Chemical Structure

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Maritinone
CAS# 33927-59-2

Theoretical Analysis

MedKoo Cat#: 561490
Name: Maritinone
CAS#: 33927-59-2
Chemical Formula: C22H14O6
Exact Mass: 374.08
Molecular Weight: 374.340
Elemental Analysis: C, 70.59; H, 3.77; O, 25.64

Price and Availability

This product is not in stock, which may be available by custom synthesis. For cost-effective reason, minimum order is 1g (price is usually high, lead time is 2~3 months, depending on the technical challenge). Quote less than 1g will not be provided. To request quote, please email to sales @medkoo.com or click below button.
Note: Price will be listed if it is available in the future.

Request quote for custom synthesis

Synonym: Maritinone;

IUPAC/Chemical Name: 5-Hydroxy-8-(4-hydroxy-7-methyl-5,8-dioxonaphthalen-1-yl)-2-methylnaphthalene-1,4-dione

InChi Key: XCRMWTKECYDCOD-UHFFFAOYSA-N

InChi Code: InChI=1S/C22H14O6/c1-9-7-15(25)19-13(23)5-3-11(17(19)21(9)27)12-4-6-14(24)20-16(26)8-10(2)22(28)18(12)20/h3-8,23-24H,1-2H3

SMILES Code: O=C1C(C)=CC(C2=C1C(C(C=CC(O)=C3C(C=C4C)=O)=C3C4=O)=CC=C2O)=O

Appearance: Solid powder

Purity: >98% (or refer to the Certificate of Analysis)

Shipping Condition: Shipped under ambient temperature as non-hazardous chemical. This product is stable enough for a few weeks during ordinary shipping and time spent in Customs.

Storage Condition: Dry, dark and at 0 - 4 C for short term (days to weeks) or -20 C for long term (months to years).

Solubility: Soluble in DMSO

Shelf Life: >2 years if stored properly

Drug Formulation: This drug may be formulated in DMSO

Stock Solution Storage: 0 - 4 C for short term (days to weeks), or -20 C for long term (months).

HS Tariff Code: 2934.99.9001

More Info:

Biological target:
In vitro activity:
In vivo activity:

Preparing Stock Solutions

The following data is based on the product molecular weight 374.34 Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.

Recalculate based on batch purity %
Concentration / Solvent Volume / Mass 1 mg 5 mg 10 mg
1 mM 1.15 mL 5.76 mL 11.51 mL
5 mM 0.23 mL 1.15 mL 2.3 mL
10 mM 0.12 mL 0.58 mL 1.15 mL
50 mM 0.02 mL 0.12 mL 0.23 mL
Formulation protocol:
In vitro protocol:
In vivo protocol:

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1: Ito C, Matsui T, Takano M, Wu TS, Itoigawa M. Anti-cell proliferation effect of naphthoquinone dimers isolated from Plumbago zeylanica. Nat Prod Res. 2017 Aug 20:1-6. doi: 10.1080/14786419.2017.1366476. [Epub ahead of print] PubMed PMID: 28823173.

2: Higa M, Takashima Y, Yokaryo H, Harie Y, Suzuka T, Ogihara K. Naphthoquinone Derivatives from Diospyros maritima. Chem Pharm Bull (Tokyo). 2017;65(8):739-745. doi: 10.1248/cpb.c17-00178. PubMed PMID: 28768928.

3: Sharma D, Yadav JP. An Overview of Phytotherapeutic Approaches for the Treatment of Tuberculosis. Mini Rev Med Chem. 2017;17(2):167-183. Review. PubMed PMID: 27145855.

4: Uc-Cachón AH, Borges-Argáez R, Said-Fernández S, Vargas-Villarreal J, González-Salazar F, Méndez-González M, Cáceres-Farfán M, Molina-Salinas GM. Naphthoquinones isolated from Diospyros anisandra exhibit potent activity against pan-resistant first-line drugs Mycobacterium tuberculosis strains. Pulm Pharmacol Ther. 2014 Feb;27(1):114-20. doi: 10.1016/j.pupt.2013.08.001. Epub 2013 Aug 20. PubMed PMID: 23968826.

5: Quintal-Novelo C, Moo-Puc RE, Chale-Dzul J, Cáceres-Farfán M, Mendez-Gonzalez M, Borges-Argáez R. Cytotoxic constituents from the stem bark of Diospyros cuneata Standl. Nat Prod Res. 2013;27(17):1594-7. doi: 10.1080/14786419.2012.738201. Epub 2012 Oct 26. PubMed PMID: 23098219.

6: Whitson EL, Sun H, Thomas CL, Henrich CJ, Sayers TJ, McMahon JB, Griesinger C, McKee TC. Synergistic TRAIL sensitizers from Barleria alluaudii and Diospyros maritima. J Nat Prod. 2012 Mar 23;75(3):394-9. doi: 10.1021/np200805z. Epub 2012 Feb 7. PubMed PMID: 22313254; PubMed Central PMCID: PMC3311710.

7: Gu JQ, Graf TN, Lee D, Chai HB, Mi Q, Kardono LB, Setyowati FM, Ismail R, Riswan S, Farnsworth NR, Cordell GA, Pezzuto JM, Swanson SM, Kroll DJ, Falkinham JO 3rd, Wall ME, Wani MC, Kinghorn AD, Oberlies NH. Cytotoxic and antimicrobial constituents of the bark of Diospyros maritima collected in two geographical locations in Indonesia. J Nat Prod. 2004 Jul;67(7):1156-61. PubMed PMID: 15270571.

8: Lin LC, Yang LL, Chou CJ. Cytotoxic naphthoquinones and plumbagic acid glucosides from Plumbago zeylanica. Phytochemistry. 2003 Feb;62(4):619-22. PubMed PMID: 12560036.