Abaperidone free base
new
featured

    WARNING: This product is for research use only, not for human or veterinary use.

MedKoo CAT#: 571332

CAS#: 183849-43-6 (free base)

Description: Abaperidone, also known as FI 8602, is an atypical antipsychotic. Reduced hsp70 in the prefrontal cortex may play a critical role in the etiology of many schizophrenia symptoms and may be linked to an atypical profile of antipsychotics, such as abaperidone.

Chemical Structure

img
Abaperidone free base
CAS# 183849-43-6 (free base)
Product data Instruction

Theoretical Analysis

MedKoo Cat#: 571332
Name: Abaperidone free base
CAS#: 183849-43-6 (free base)
Chemical Formula: C25H25FN2O5
Exact Mass: 452.17
Molecular Weight: 452.482
Elemental Analysis: C, 66.36; H, 5.57; F, 4.20; N, 6.19; O, 17.68

Price and Availability

Size Price Availability Quantity
1mg USD 90 Ready to Ship
5mg USD 250 Ready to Ship
10mg USD 450 Ready to Ship
25mg USD 750 Ready to Ship
50mg USD 1250 Ready to Ship
100mg USD 2250 Ready to Ship
Bulk inquiry

Related CAS #: 183849-45-8 (HCl)   183849-43-6 (free base)    

Synonym: Abaperidone; Abaperidone free base; FI 8602; FI-8602; FI8602;

IUPAC/Chemical Name: 7-(3-(4-(6-Fluoro-1,2-benzisoxazol-3-yl)piperidino)propoxy)-3-(hydroxymethyl)-4H-1-benzopyran-4-one

InChi Key: ICAXEUYZCLRXKY-UHFFFAOYSA-N

InChi Code: InChI=1S/C25H25FN2O5/c26-18-2-4-20-23(12-18)33-27-24(20)16-6-9-28(10-7-16)8-1-11-31-19-3-5-21-22(13-19)32-15-17(14-29)25(21)30/h2-5,12-13,15-16,29H,1,6-11,14H2

SMILES Code: O=C1C(CO)=COC2=CC(OCCCN3CCC(C4=NOC5=C4C=CC(F)=C5)CC3)=CC=C12

Appearance: Solid powder

Purity: >98% (or refer to the Certificate of Analysis)

Shipping Condition: Shipped under ambient temperature as non-hazardous chemical. This product is stable enough for a few weeks during ordinary shipping and time spent in Customs.

Storage Condition: Dry, dark and at 0 - 4 C for short term (days to weeks) or -20 C for long term (months to years).

Solubility: Soluble in DMSO

Shelf Life: >2 years if stored properly

Drug Formulation: This drug may be formulated in DMSO

Stock Solution Storage: 0 - 4 C for short term (days to weeks), or -20 C for long term (months).

HS Tariff Code: 2934.99.9001

More Info:

Biological target: Abaperidone is a potent antagonist of 5-HT2A receptor and dopamine D2 receptor with IC50s of 6.2 and 17 nM.
In vitro activity: TBD
In vivo activity: Abaperidone, a novel drug with an atypical antipsychotic profile, was compared, at pharmacologically equivalent doses, with the atypical antipsychotics clozapine and risperidone and also with haloperidol, a classical antipsychotic. Abaperidone and clozapine reduced basal hsp70 mRNA expression in the rat striatum and in the prefrontal cortex. Reference: Prog Neuropsychopharmacol Biol Psychiatry. https://pubmed.ncbi.nlm.nih.gov/12551723/

Preparing Stock Solutions

The following data is based on the product molecular weight 452.48 Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.

Recalculate based on batch purity %
Concentration / Solvent Volume / Mass 1 mg 5 mg 10 mg
1 mM 1.15 mL 5.76 mL 11.51 mL
5 mM 0.23 mL 1.15 mL 2.3 mL
10 mM 0.12 mL 0.58 mL 1.15 mL
50 mM 0.02 mL 0.12 mL 0.23 mL
Formulation protocol: 1. García-Osta A, Frechilla D, Del Río J. Reduced basal and phencyclidine-induced expression of heat shock protein-70 in rat prefrontal cortex by the atypical antipsychotic abaperidone. Prog Neuropsychopharmacol Biol Psychiatry. 2003 Feb;27(1):31-6. doi: 10.1016/s0278-5846(02)00311-1. PMID: 12551723.
In vitro protocol: TBD
In vivo protocol: 1. García-Osta A, Frechilla D, Del Río J. Reduced basal and phencyclidine-induced expression of heat shock protein-70 in rat prefrontal cortex by the atypical antipsychotic abaperidone. Prog Neuropsychopharmacol Biol Psychiatry. 2003 Feb;27(1):31-6. doi: 10.1016/s0278-5846(02)00311-1. PMID: 12551723.

Molarity Calculator

Calculate the mass, volume, or concentration required for a solution.
=
x
x
g/mol

*When preparing stock solutions always use the batch-specific molecular weight of the product found on the vial label and SDS / CoA (available online).

Reconstitution Calculator

The reconstitution calculator allows you to quickly calculate the volume of a reagent to reconstitute your vial. Simply enter the mass of reagent and the target concentration and the calculator will determine the rest.

=
÷

Dilution Calculator

Calculate the dilution required to prepare a stock solution.
x
=
x

1: García-Osta A, Frechilla D, Del Río J. Reduced basal and phencyclidine induced expression of heat shock protein-70 in rat prefrontal cortex by the atypical antipsychotic abaperidone. Prog Neuropsychopharmacol Biol Psychiatry. 2003 Feb;27(1):31-6. PubMed PMID: 12551723.

2: Bolós J, Anglada L, Gubert S, Planas JM, Agut J, Príncep M, De la Fuente N, Sacristán A, Ortiz JA. 7-[3-(1-piperidinyl)propoxy]chromenones as potential atypical antipsychotics. 2. Pharmacological profile of 7-[3-[4-(6-fluoro-1, 2-benzisoxazol-3-yl)-piperidin-1-yl]propoxy]-3-(hydroxymeth yl)chromen -4-one (abaperidone, FI-8602). J Med Chem. 1998 Dec 31;41(27):5402-9. PubMed PMID: 9876110.