nor-NOHA acetate

    WARNING: This product is for research use only, not for human or veterinary use.

MedKoo CAT#: 530935

CAS#: 1140844-63-8 (acetate)

Description: nor-NOHA is a potent, selective, competitive, and high affinity inhibitor of arginase. nor-NOHA inhibits arginase from rat liver (IC50 = 2 µM) and mouse macrophages (IC50 = 50 µM).

Chemical Structure

nor-NOHA acetate
CAS# 1140844-63-8 (acetate)

Theoretical Analysis

MedKoo Cat#: 530935
Name: nor-NOHA acetate
CAS#: 1140844-63-8 (acetate)
Chemical Formula: C9H20N4O7
Exact Mass:
Molecular Weight: 296.28
Elemental Analysis: C, 36.49; H, 6.80; N, 18.91; O, 37.80

Price and Availability

Size Price Availability Quantity
5.0mg USD 250.0 2 Weeks
10.0mg USD 450.0 2 Weeks
50.0mg USD 1150.0 2 Weeks
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Related CAS #: 189302-40-7 (free base)   1140844-63-8 (acetate)   291758-32-2 (HCl)    

Synonym: nor-NOHA acetate, N(ω)-hydroxy-nor-L-arginine.

IUPAC/Chemical Name: (2S)-2-Amino-(4-(2ʹ-hydroxyguanidino))butyric Acid; acetic acid (1:2)


InChi Code: InChI=1S/C5H12N4O3.2C2H4O2/c6-3(4(10)11)1-2-8-5(7)9-12;2*1-2(3)4/h3,12H,1-2,6H2,(H,10,11)(H3,7,8,9);2*1H3,(H,3,4)/t3-;;/m0../s1

SMILES Code: O=C(O)[C@@H](N)CCN/C(N)=N/O.CC(O)=O.CC(O)=O

Appearance: Solid powder

Purity: >98% (or refer to the Certificate of Analysis)

Shipping Condition: Shipped under ambient temperature as non-hazardous chemical. This product is stable enough for a few weeks during ordinary shipping and time spent in Customs.

Storage Condition: Dry, dark and at 0 - 4 C for short term (days to weeks) or -20 C for long term (months to years).

Solubility: Soluble in DMSO

Shelf Life: >2 years if stored properly

Drug Formulation: This drug may be formulated in DMSO

Stock Solution Storage: 0 - 4 C for short term (days to weeks), or -20 C for long term (months).

HS Tariff Code: 2934.99.9001

Preparing Stock Solutions

The following data is based on the product molecular weight 296.28 Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.

Recalculate based on batch purity %
Concentration / Solvent Volume / Mass 1 mg 5 mg 10 mg
1 mM 1.15 mL 5.76 mL 11.51 mL
5 mM 0.23 mL 1.15 mL 2.3 mL
10 mM 0.12 mL 0.58 mL 1.15 mL
50 mM 0.02 mL 0.12 mL 0.23 mL

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4: Havlinova Z, Babicova A, Hroch M, Chladek J. Comparative pharmacokinetics of N(ω)-hydroxy-nor-L-arginine, an arginase inhibitor, after single-dose intravenous, intraperitoneal and intratracheal administration to brown Norway rats. Xenobiotica. 2013 Oct;43(10):886-94. doi: 10.3109/00498254.2013.780672. Epub 2013 Mar 21. PubMed PMID: 23517541.

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9: Bagnost T, Guillaume YC, Thomassin M, Robert JF, Berthelot A, Xicluna A, André C. Immobilization of arginase and its application in an enzymatic chromatographic column: thermodynamic studies of nor-NOHA/arginase binding and role of the reactive histidine residue. J Chromatogr B Analyt Technol Biomed Life Sci. 2007 Sep 1;856(1-2):113-20. Epub 2007 Jun 2. PubMed PMID: 17588506.

10: Lasch M, Caballero-Martinez A, Troidl K, Schloegl I, Lautz T, Deindl E. Arginase inhibition attenuates arteriogenesis and interferes with M2 macrophage accumulation. Lab Invest. 2016 Aug;96(8):830-8. doi: 10.1038/labinvest.2016.62. Epub 2016 May 30. PubMed PMID: 27239731.

11: Bagnost T, Guillaume YC, Thomassin M, Berthelot A, Demougeot C, André C. Biochromatographic framework for analyzing magnesium chloride salt dependence on nor-NOHA binding to arginase enzyme. J Chromatogr B Analyt Technol Biomed Life Sci. 2008 Sep 15;873(1):37-40. doi: 10.1016/j.jchromb.2008.07.024. Epub 2008 Jul 29. PubMed PMID: 18723409.

12: Arıkan-Ayyıldız Z, Karaman M, Tuncel T, Kiray M, Bağrıyanık A, Yilmaz O, Uzuner N, Karaman O. Beneficial effects of arginase inhibition and inhaled L-arginine administration on airway histology in a murine model of chronic asthma. Allergol Immunopathol (Madr). 2014 Jul-Aug;42(4):316-23. doi: 10.1016/j.aller.2013.01.001. Epub 2013 Apr 8. PubMed PMID: 23578782.

13: Tratsiakovich Y, Gonon AT, Krook A, Yang J, Shemyakin A, Sjöquist PO, Pernow J. Arginase inhibition reduces infarct size via nitric oxide, protein kinase C epsilon and mitochondrial ATP-dependent K+ channels. Eur J Pharmacol. 2013 Jul 15;712(1-3):16-21. doi: 10.1016/j.ejphar.2013.04.044. Epub 2013 May 9. PubMed PMID: 23665492.

14: Li X, Zhu F, He Y, Luo F. [Arginase inhibitor nor-NOHA induces apoptosis and inhibits invasion and migration of HepG2 cells]. Xi Bao Yu Fen Zi Mian Yi Xue Za Zhi. 2017 Apr;33(4):477-482. Chinese. PubMed PMID: 28395717.

15: Ogino K, Kubo M, Takahashi H, Zhang R, Zou Y, Fujikura Y. Anti-inflammatory effect of arginase inhibitor and corticosteroid on airway allergic reactions in a Dermatophogoides farinae-induced NC/Nga mouse model. Inflammation. 2013 Feb;36(1):141-51. doi: 10.1007/s10753-012-9529-3. PubMed PMID: 22915279.

16: Gonon AT, Jung C, Katz A, Westerblad H, Shemyakin A, Sjöquist PO, Lundberg JO, Pernow J. Local arginase inhibition during early reperfusion mediates cardioprotection via increased nitric oxide production. PLoS One. 2012;7(7):e42038. doi: 10.1371/journal.pone.0042038. Epub 2012 Jul 31. PubMed PMID: 22860052; PubMed Central PMCID: PMC3409239.

17: Shemyakin A, Kövamees O, Rafnsson A, Böhm F, Svenarud P, Settergren M, Jung C, Pernow J. Arginase inhibition improves endothelial function in patients with coronary artery disease and type 2 diabetes mellitus. Circulation. 2012 Dec 18;126(25):2943-50. doi: 10.1161/CIRCULATIONAHA.112.140335. Epub 2012 Nov 26. PubMed PMID: 23183942.

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20: Huynh NN, Harris EE, Chin-Dusting JF, Andrews KL. The vascular effects of different arginase inhibitors in rat isolated aorta and mesenteric arteries. Br J Pharmacol. 2009 Jan;156(1):84-93. doi: 10.1111/j.1476-5381.2008.00036.x. PubMed PMID: 19133993; PubMed Central PMCID: PMC2697778.