WARNING: This product is for research use only, not for human or veterinary use.
MedKoo CAT#: 530925
Description: VU0422288, also known as ML 396, is a positive allosteric modulator (EC50 values are 108, 125 and 146 nM for mGlu4, mGlu8 and mGlu7 respectively).
MedKoo Cat#: 530925
Chemical Formula: C17H11Cl2N3O2
Exact Mass: 359.0228
Molecular Weight: 360.194
Elemental Analysis: C, 56.69; H, 3.08; Cl, 19.68; N, 11.67; O, 8.88
Synonym: VU0422288; VU-0422288; VU 0422288; ML 396; ML-396; ML396.
IUPAC/Chemical Name: N-[3-Chloro-4-[(5-chloro-2-pyridinyl)oxy]phenyl]-2-pyridinecarboxamide
InChi Key: MZRLPXFGQKQHST-UHFFFAOYSA-N
InChi Code: InChI=1S/C17H11Cl2N3O2/c18-11-4-7-16(21-10-11)24-15-6-5-12(9-13(15)19)22-17(23)14-3-1-2-8-20-14/h1-10H,(H,22,23)
SMILES Code: O=C(C1=NC=CC=C1)NC2=CC=C(OC3=NC=C(Cl)C=C3)C(Cl)=C2
Metabotropic glutamate receptor 7 (mGlu7) is a member of the group III mGlu receptors (mGlus), encompassed by mGlu4, mGlu6, mGlu7, and mGlu8. mGlu7 is highly expressed in the presynaptic active zones of both excitatory and inhibitory synapses, and activation of the receptor regulates the release of both glutamate and GABA. mGlu7 is thought to be a relevant therapeutic target for a number of neurological and psychiatric disorders, and polymorphisms in the GRM7 gene have been linked to autism, depression, ADHD, and schizophrenia.
1: Jalan-Sakrikar N, Field JR, Klar R, Mattmann ME, Gregory KJ, Zamorano R,
Engers DW, Bollinger SR, Weaver CD, Days EL, Lewis LM, Utley TJ, Hurtado M,
Rigault D, Acher F, Walker AG, Melancon BJ, Wood MR, Lindsley CW, Conn PJ, Xiang
Z, Hopkins CR, Niswender CM. Identification of positive allosteric modulators
VU0155094 (ML397) and VU0422288 (ML396) reveals new insights into the biology of
metabotropic glutamate receptor 7. ACS Chem Neurosci. 2014 Dec 17;5(12):1221-37.
doi: 10.1021/cn500153z. Epub 2014 Oct 9. PubMed PMID: 25225882; PubMed Central