VU6005649
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    WARNING: This product is for research use only, not for human or veterinary use.

MedKoo CAT#: 530923

CAS#: 2137047-43-7

Description: VU6005649 is a potent and CNS Penetrant mGlu7/8 Receptor PAM with in vivo efficacy in a mouse contextual fear conditioning model.

Chemical Structure

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VU6005649
CAS# 2137047-43-7
Instruction

Theoretical Analysis

MedKoo Cat#: 530923
Name: VU6005649
CAS#: 2137047-43-7
Chemical Formula: C16H12F5N3O
Exact Mass: 357.09
Molecular Weight: 357.284
Elemental Analysis: C, 53.79; H, 3.39; F, 26.59; N, 11.76; O, 4.48

Price and Availability

Size Price Availability Quantity
10mg USD 335
50mg USD 1105
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Synonym: VU6005649; VU-6005649; VU 6005649

IUPAC/Chemical Name: 3-(2,3-Difluoro-4-methoxy-phenyl)-2,5-dimethyl-7-(trifluoromethyl)pyrazolo[1,5-a]pyrimidine

InChi Key: NYBZCKAQIIPSDS-UHFFFAOYSA-N

InChi Code: InChI=1S/C16H12F5N3O/c1-7-6-11(16(19,20)21)24-15(22-7)12(8(2)23-24)9-4-5-10(25-3)14(18)13(9)17/h4-6H,1-3H3

SMILES Code: FC(C1=CC(C)=NC2=C(C3=CC=C(OC)C(F)=C3F)C(C)=NN12)(F)F

Appearance: Solid powder

Purity: >98% (or refer to the Certificate of Analysis)

Shipping Condition: Shipped under ambient temperature as non-hazardous chemical. This product is stable enough for a few weeks during ordinary shipping and time spent in Customs.

Storage Condition: Dry, dark and at 0 - 4 C for short term (days to weeks) or -20 C for long term (months to years).

Solubility: Soluble in DMSO

Shelf Life: >2 years if stored properly

Drug Formulation: This drug may be formulated in DMSO

Stock Solution Storage: 0 - 4 C for short term (days to weeks), or -20 C for long term (months).

HS Tariff Code: 2934.99.9001

More Info:

Biological target:
In vitro activity:
In vivo activity:

Preparing Stock Solutions

The following data is based on the product molecular weight 357.28 Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.

Recalculate based on batch purity %
Concentration / Solvent Volume / Mass 1 mg 5 mg 10 mg
1 mM 1.15 mL 5.76 mL 11.51 mL
5 mM 0.23 mL 1.15 mL 2.3 mL
10 mM 0.12 mL 0.58 mL 1.15 mL
50 mM 0.02 mL 0.12 mL 0.23 mL
Formulation protocol:
In vitro protocol:
In vivo protocol:

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Abe et al (2017) Discovery of VU6005649, a CNS penetrant mGlu7/8 receptor PAM derived from a series of pyrazolo[1,5-a]pyrimidines. ACS.Med.Chem.Lett. 8 1110 PMID: 29057060