VU6005649
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    WARNING: This product is for research use only, not for human or veterinary use.

MedKoo CAT#: 530923

CAS#: 2137047-43-7

Description: VU6005649 is a potent and CNS Penetrant mGlu7/8 Receptor PAM with in vivo efficacy in a mouse contextual fear conditioning model.


Price and Availability

Size Price Shipping out time Quantity
10mg USD 335 2 Weeks
50mg USD 1105 2 Weeks
Inquire bulk and customized quantity

Pricing updated 2020-10-20. Prices are subject to change without notice.

VU6005649, purity > 98%, is in stock. Current shipping out time is about 2 weeks after order is received. CoA, QC data and MSDS documents are available in one week after order is received.


Chemical Structure

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Theoretical Analysis

MedKoo Cat#: 530923
Name: VU6005649
CAS#: 2137047-43-7
Chemical Formula: C16H12F5N3O
Exact Mass: 357.0901
Molecular Weight: 357.284
Elemental Analysis: C, 53.79; H, 3.39; F, 26.59; N, 11.76; O, 4.48


Synonym: VU6005649; VU-6005649; VU 6005649

IUPAC/Chemical Name: 3-(2,3-Difluoro-4-methoxy-phenyl)-2,5-dimethyl-7-(trifluoromethyl)pyrazolo[1,5-a]pyrimidine

InChi Key: NYBZCKAQIIPSDS-UHFFFAOYSA-N

InChi Code: InChI=1S/C16H12F5N3O/c1-7-6-11(16(19,20)21)24-15(22-7)12(8(2)23-24)9-4-5-10(25-3)14(18)13(9)17/h4-6H,1-3H3

SMILES Code: FC(C1=CC(C)=NC2=C(C3=CC=C(OC)C(F)=C3F)C(C)=NN12)(F)F


Technical Data

Appearance:
Solid powder

Purity:
>98% (or refer to the Certificate of Analysis)

Shipping Condition:
Shipped under ambient temperature as non-hazardous chemical. This product is stable enough for a few weeks during ordinary shipping and time spent in Customs.

Storage Condition:
Dry, dark and at 0 - 4 C for short term (days to weeks) or -20 C for long term (months to years).

Solubility:
Soluble in DMSO

Shelf Life:
>2 years if stored properly

Drug Formulation:
This drug may be formulated in DMSO

Stock Solution Storage:
0 - 4 C for short term (days to weeks), or -20 C for long term (months).

HS Tariff Code:
2934.99.9001


References

Abe et al (2017) Discovery of VU6005649, a CNS penetrant mGlu7/8 receptor PAM derived from a series of pyrazolo[1,5-a]pyrimidines. ACS.Med.Chem.Lett. 8 1110 PMID: 29057060