ML-030
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MedKoo CAT#: 530919

CAS#: 1013750-77-0

Description: ML-030, also known as CID-11757146, is a potent and selective PDE4 inhibitor. ML-030 inhibits PDE4 in a cell-based cyclic nucleotide-gated cation channel biosensor assay with an EC50 value of 18.7 nM.

Chemical Structure

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ML-030
CAS# 1013750-77-0
Product data Instruction

Theoretical Analysis

MedKoo Cat#: 530919
Name: ML-030
CAS#: 1013750-77-0
Chemical Formula: C20H20N4O4S
Exact Mass: 412.12
Molecular Weight: 412.464
Elemental Analysis: C, 58.24; H, 4.89; N, 13.58; O, 15.52; S, 7.77

Price and Availability

Size Price Availability Quantity
5g USD -1
100mg USD 1350
200mg USD 1950
500mg USD 2650
1g USD 3650
2g USD 5450
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Synonym: ML-030; ML 030; ML030; CID-11757146; CID 11757146; CID11757146.

IUPAC/Chemical Name: 3-(2,5-dimethoxyphenyl)-6-(3,4-dimethoxyphenyl)-7H-1,2,4-triazolo[3,4-b][1,3,4]thiadiazine

InChi Key: DZAUSKKPHXFGNN-UHFFFAOYSA-N

InChi Code: InChI=1S/C20H20N4O4S/c1-25-13-6-8-16(26-2)14(10-13)19-21-22-20-24(19)23-15(11-29-20)12-5-7-17(27-3)18(9-12)28-4/h5-10H,11H2,1-4H3

SMILES Code: COC1=CC=C(C2=NN3C(SC2)=NN=C3C4=CC(OC)=CC=C4OC)C=C1OC

Appearance: Solid powder

Purity: >98% (or refer to the Certificate of Analysis)

Shipping Condition: Shipped under ambient temperature as non-hazardous chemical. This product is stable enough for a few weeks during ordinary shipping and time spent in Customs.

Storage Condition: Dry, dark and at 0 - 4 C for short term (days to weeks) or -20 C for long term (months to years).

Solubility: Soluble in DMSO

Shelf Life: >2 years if stored properly

Drug Formulation: This drug may be formulated in DMSO

Stock Solution Storage: 0 - 4 C for short term (days to weeks), or -20 C for long term (months).

HS Tariff Code: 2934.99.9001

More Info: Type 4 cyclic nucleotide phosphodiesterases (PDE4s), which are highly expressed in neutrophils and monocytes, selectively inactivate the second messenger cAMP by hydrolyzing the phosphodiester bond, producing AMP.

Product Data:
Product Data
Instruction:
View handling instruction
Biological target: ML-030 is a potent PDE4 inhibitor.
In vitro activity: TBD
In vivo activity: TBD

Solubility Data

Solvent Max Conc. mg/mL Max Conc. mM
Solubility
DMSO 27.5 66.67

Preparing Stock Solutions

The following data is based on the product molecular weight 412.46 Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.

Recalculate based on batch purity %
Concentration / Solvent Volume / Mass 1 mg 5 mg 10 mg
1 mM 1.15 mL 5.76 mL 11.51 mL
5 mM 0.23 mL 1.15 mL 2.3 mL
10 mM 0.12 mL 0.58 mL 1.15 mL
50 mM 0.02 mL 0.12 mL 0.23 mL
Formulation protocol: TBD
In vitro protocol: TBD
In vivo protocol: TBD

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