WARNING: This product is for research use only, not for human or veterinary use.
MedKoo CAT#: 530918
Description: ZINC00881524 is a potent and selective ROCK inhibitor. Clinically, inhibition of ROCK pathway is believed to contribute to some of the cardiovascular benefits of statin therapy that are independent of lipid lowering (ie, pleiotropic effects).
MedKoo Cat#: 530918
Chemical Formula: C21H20N2O3S
Exact Mass: 380.1195
Molecular Weight: 380.462
Elemental Analysis: C, 66.30; H, 5.30; N, 7.36; O, 12.62; S, 8.43
Synonym: ZINC00881524; ZINC-00881524; ZINC 00881524.
IUPAC/Chemical Name: N-(4,5-dihydronaphtho[1,2-d]thiazol-2-yl)-2-(3,4-dimethoxyphenyl)acetamide
InChi Key: DQNMDJGZWFZNHS-UHFFFAOYSA-N
InChi Code: InChI=1S/C21H20N2O3S/c1-25-16-9-7-13(11-17(16)26-2)12-19(24)22-21-23-20-15-6-4-3-5-14(15)8-10-18(20)27-21/h3-7,9,11H,8,10,12H2,1-2H3,(H,22,23,24)
SMILES Code: O=C(NC1=NC2=C(CCC3=C2C=CC=C3)S1)CC4=CC=C(OC)C(OC)=C4
The Rho kinase (ROCK) isoforms, ROCK1 and ROCK2, were initially discovered as downstream targets of the small GTP-binding protein Rho. Because ROCKs mediate various important cellular functions such as cell shape, motility, secretion, proliferation, and gene expression, it is likely that this pathway will intersect with other signaling pathways known to contribute to cardiovascular disease. Indeed, ROCKs have already been implicated in the regulation of vascular tone, proliferation, inflammation, and oxidative stress. However, it is not entirely clear how ROCKs are regulated, what some of their downstream targets are, and whether ROCK1 and ROCK2 mediate different cellular functions.