Parathion
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MedKoo CAT#: 571292

CAS#: 56-38-2

Description: Parathion is a highly toxic cholinesterase inhibitor that is used as an acaricide and as an insecticide.


Price and Availability

Size Price Shipping out time Quantity
100mg USD 190 2 Weeks
Inquire bulk and customized quantity

Pricing updated 2020-07-11. Prices are subject to change without notice.

Parathion, purity > 98%, is in stock. Current shipping out time is about 2 weeks after order is received. CoA, QC data and MSDS documents are available in one week after order is received.


Chemical Structure

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Theoretical Analysis

MedKoo Cat#: 571292
Name: Parathion
CAS#: 56-38-2
Chemical Formula: C10H14NO5PS
Exact Mass: 291.033
Molecular Weight: 291.26
Elemental Analysis: C, 41.24; H, 4.85; N, 4.81; O, 27.47; P, 10.63; S, 11.01


Synonym: Parathion; Aphamite; Corothion; Murfos ; NSC 8933; NSC-8933; NSC8933

IUPAC/Chemical Name: O,O-diethyl O-(4-nitrophenyl) phosphorothioate

InChi Key: LCCNCVORNKJIRZ-UHFFFAOYSA-N

InChi Code: InChI=1S/C10H14NO5PS/c1-3-14-17(18,15-4-2)16-10-7-5-9(6-8-10)11(12)13/h5-8H,3-4H2,1-2H3

SMILES Code: S=P(OCC)(OCC)OC1=CC=C([N+]([O-])=O)C=C1


Technical Data

Appearance:
Solid powder

Purity:
>98% (or refer to the Certificate of Analysis)

Shipping Condition:
Shipped under ambient temperature as non-hazardous chemical. This product is stable enough for a few weeks during ordinary shipping and time spent in Customs.

Storage Condition:
Dry, dark and at 0 - 4 C for short term (days to weeks) or -20 C for long term (months to years).

Solubility:
Soluble in DMSO

Shelf Life:
>2 years if stored properly

Drug Formulation:
This drug may be formulated in DMSO

Stock Solution Storage:
0 - 4 C for short term (days to weeks), or -20 C for long term (months).

HS Tariff Code:
2934.99.9001


References

1: Shi H, Sheng E, Feng L, Zhou L, Hua X, Wang M. Simultaneous detection of imidacloprid and parathion by the dual-labeled time-resolved fluoroimmunoassay. Environ Sci Pollut Res Int. 2015 Oct;22(19):14882-90. doi: 10.1007/s11356-015-4697-y. Epub 2015 May 22. PubMed PMID: 25994268.

2: Tabassum N, Rafique U, Balkhair KS, Ashraf MA. Chemodynamics of methyl parathion and ethyl parathion: adsorption models for sustainable agriculture. Biomed Res Int. 2014;2014:831989. doi: 10.1155/2014/831989. Epub 2014 Feb 6. PubMed PMID: 24689059; PubMed Central PMCID: PMC3932840.

3: Liu G, Guo W, Yin Z. Covalent fabrication of methyl parathion hydrolase on gold nanoparticles modified carbon substrates for designing a methyl parathion biosensor. Biosens Bioelectron. 2014 Mar 15;53:440-6. doi: 10.1016/j.bios.2013.10.025. Epub 2013 Oct 24. PubMed PMID: 24211455.

4: Jan YH, Richardson JR, Baker AA, Mishin V, Heck DE, Laskin DL, Laskin JD. Novel approaches to mitigating parathion toxicity: targeting cytochrome P450-mediated metabolism with menadione. Ann N Y Acad Sci. 2016 Aug;1378(1):80-86. doi: 10.1111/nyas.13156. Epub 2016 Jul 21. Review. PubMed PMID: 27441453; PubMed Central PMCID: PMC5220671.

5: Halaimi FZ, Kellali Y, Couderchet M, Semsari S. Comparison of biosorption and phytoremediation of cadmium and methyl parathion, a case-study with live Lemna gibba and Lemna gibba powder. Ecotoxicol Environ Saf. 2014 Jul;105:112-20. doi: 10.1016/j.ecoenv.2014.02.002. Epub 2014 May 7. Review. PubMed PMID: 24815048.

6: Liao X, Zhang C, Liu Y, Luo Y, Wu S, Yuan S, Zhu Z. Abiotic degradation of methyl parathion by manganese dioxide: Kinetics and transformation pathway. Chemosphere. 2016 May;150:90-96. doi: 10.1016/j.chemosphere.2016.02.028. Epub 2016 Feb 16. PubMed PMID: 26891361.

7: Edwards FL, Yedjou CG, Tchounwou PB. Involvement of oxidative stress in methyl parathion and parathion-induced toxicity and genotoxicity to human liver carcinoma (HepG₂) cells. Environ Toxicol. 2013 Jun;28(6):342-8. doi: 10.1002/tox.20725. Epub 2011 May 4. PubMed PMID: 21544925; PubMed Central PMCID: PMC3768275.

8: Valdes SA, Vieira LG, Ferreira CH, dos Santos Mendonça J, Ribeiro PR, de Abreu Fernandes E, Santos AL. Effects of Exposure to Methyl Parathion on Egg Hatchability and Eggshell Chemical Composition in Podocnemis expansa (Testudines, Podocnemididae). Zoolog Sci. 2015 Apr;32(2):135-40. doi: 10.2108/zs140164. PubMed PMID: 25826061.

9: Xu S, Guo C, Li Y, Yu Z, Wei C, Tang Y. Methyl parathion imprinted polymer nanoshell coated on the magnetic nanocore for selective recognition and fast adsorption and separation in soils. J Hazard Mater. 2014 Jan 15;264:34-41. doi: 10.1016/j.jhazmat.2013.10.060. Epub 2013 Nov 2. PubMed PMID: 24275470.

10: Tan L, Li W, Li H, Tang Y. Development of surface imprinted core-shell nanoparticles and their application in a solid-phase dispersion extraction matrix for methyl parathion. J Chromatogr A. 2014 Apr 4;1336:59-66. doi: 10.1016/j.chroma.2014.02.011. Epub 2014 Feb 8. PubMed PMID: 24576608.

11: Gerent GG, Spinelli A. Environmentally-friendly in situ plated bismuth-film electrode for the quantification of the endocrine disruptor parathion in skimmed milk. J Hazard Mater. 2016 May 5;308:157-63. doi: 10.1016/j.jhazmat.2016.01.038. Epub 2016 Jan 16. PubMed PMID: 26812083.

12: Zhao Y, Zhang W, Lin Y, Du D. The vital function of Fe3O4@Au nanocomposites for hydrolase biosensor design and its application in detection of methyl parathion. Nanoscale. 2013 Feb 7;5(3):1121-6. doi: 10.1039/c2nr33107a. Epub 2013 Jan 2. PubMed PMID: 23280070.

13: Ben Salem I, Fekih S, Sghaier H, Bousselmi M, Saidi M, Landoulsi A, Fattouch S. Effect of ionising radiation on polyphenolic content and antioxidant potential of parathion-treated sage (Salvia officinalis) leaves. Food Chem. 2013 Nov 15;141(2):1398-405. doi: 10.1016/j.foodchem.2013.04.008. Epub 2013 Apr 18. PubMed PMID: 23790930.

14: Ibrahim R, Kasting GB. Partitioning and diffusion of parathion in human dermis. Int J Pharm. 2012 Oct 1;435(1):33-7. doi: 10.1016/j.ijpharm.2012.03.023. Epub 2012 Mar 29. PubMed PMID: 22484178.

15: Patnaik R, Padhy RN. Evaluation of geno-toxicity of methyl parathion and chlorpyrifos to human liver carcinoma cell line (HepG2). Environ Sci Pollut Res Int. 2016 May;23(9):8492-9. doi: 10.1007/s11356-015-5963-8. Epub 2016 Jan 19. PubMed PMID: 26782680.

16: Foxenberg RJ, Ellison CA, Knaak JB, Ma C, Olson JR. Cytochrome P450-specific human PBPK/PD models for the organophosphorus pesticides: chlorpyrifos and parathion. Toxicology. 2011 Jul 11;285(1-2):57-66. doi: 10.1016/j.tox.2011.04.002. Epub 2011 Apr 13. PubMed PMID: 21514354.

17: Anh DH, Cheunrungsikul K, Wichitwechkarn J, Surareungchai W. A colorimetric assay for determination of methyl parathion using recombinant methyl parathion hydrolase. Biotechnol J. 2011 May;6(5):565-71. doi: 10.1002/biot.201000348. Epub 2011 Mar 7. PubMed PMID: 21381204.

18: Kumar J, D'Souza SF. Microbial biosensor for detection of methyl parathion using screen printed carbon electrode and cyclic voltammetry. Biosens Bioelectron. 2011 Jul 15;26(11):4289-93. doi: 10.1016/j.bios.2011.04.027. Epub 2011 Apr 22. PubMed PMID: 21605969.

19: Pino NJ, Dominguez MC, Penuela GA. Isolation of a selected microbial consortium capable of degrading methyl parathion and p-nitrophenol from a contaminated soil site. J Environ Sci Health B. 2011;46(2):173-80. doi: 10.1080/03601234.2011.539142. PubMed PMID: 21328125.

20: Yao JJ, Gao NY, Deng Y, Ma Y, Li HJ, Xu B, Li L. Sonolytic degradation of parathion and the formation of byproducts. Ultrason Sonochem. 2010 Jun;17(5):802-9. doi: 10.1016/j.ultsonch.2010.01.016. Epub 2010 Feb 4. PubMed PMID: 20303819.