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MedKoo CAT#: 407806

CAS#: 1428339-47-2

Description: V-11-0711 is a Chk-α inhibitor. V-11-0711 reduced the function of Chk-α by binding to the active site and inhibiting the catalytic activity but did not affect Chk-α protein levels. Chk-α protein and PtdCho, but not PC, may be essential in cancer cell proliferation.

Price and Availability

Size Price Shipping out time Quantity
2mg USD 90 Same day
5mg USD 250 Same day
10mg USD 450 Same day
25mg USD 950 Same day
50mg USD 1650 Same day
100mg USD 2950 Same day
Inquire bulk and customized quantity

Pricing updated 2020-05-28. Prices are subject to change without notice.

V-11-0711 is in stock. The same day shipping after order is received.

Chemical Structure


Theoretical Analysis

MedKoo Cat#: 407806
Name: V-11-0711
CAS#: 1428339-47-2
Chemical Formula: C27H35NO3
Exact Mass: 421.2617
Molecular Weight: 421.581
Elemental Analysis: C, 76.92; H, 8.37; N, 3.32; O, 11.39

Related CAS #: 1428338-79-7 (RR-isomer)   1428339-47-2  

Synonym: V-11-0711; V11-0711; V 11-0711; V-110711; V110711; V 110711.

IUPAC/Chemical Name: (1S)-1-phenyl-1-((1R,4R)-quinuclidin-3-yl)-3-(2-((tetrahydro-2H-pyran-4-yl)oxy)phenyl)propan-1-ol


InChi Code: InChI=1S/C27H35NO3/c29-27(23-7-2-1-3-8-23,25-20-28-16-11-21(25)12-17-28)15-10-22-6-4-5-9-26(22)31-24-13-18-30-19-14-24/h1-9,21,24-25,29H,10-20H2/t25?,27-/m1/s1


Technical Data

Solid powder

>98% (or refer to the Certificate of Analysis)

Certificate of Analysis:

Safety Data Sheet (SDS):

Shipping Condition:
Shipped under ambient temperature as non-hazardous chemical. This product is stable enough for a few weeks during ordinary shipping and time spent in Customs.

Storage Condition:
Dry, dark and at 0 - 4 C for short term (days to weeks) or -20 C for long term (months to years).

Soluble in DMSO

Shelf Life:
>2 years if stored properly

Drug Formulation:
This drug may be formulated in DMSO

Stock Solution Storage:
0 - 4 C for short term (days to weeks), or -20 C for long term (months).

HS Tariff Code:

Additional Information

Phosphatidylcholine (PtdCho) has important roles in membrane structure and cell signaling. Increased levels of choline kinase (Chk)-α, the enzyme that converts choline to phosphocholine (PC) in the PtdCho biosynthesis, and PC are consistently observed in aggressive cancers including breast cancer [1-3]. Understanding the roles of Chk-α in cancer can result in new therapies.


1: Koch K, Hartmann R, Schröter F, Suwala AK, Maciaczyk D, Krüger AC, Willbold D,
Kahlert UD, Maciaczyk J. Reciprocal regulation of the cholinic phenotype and
epithelial-mesenchymal transition in glioblastoma cells. Oncotarget. 2016 Nov
8;7(45):73414-73431. doi: 10.18632/oncotarget.12337. PubMed PMID: 27705917;
PubMed Central PMCID: PMC5341988.

2: Mori N, Wildes F, Kakkad S, Jacob D, Solaiyappan M, Glunde K, Bhujwalla ZM.
Choline kinase-α protein and phosphatidylcholine but not phosphocholine are
required for breast cancer cell survival. NMR Biomed. 2015 Dec;28(12):1697-706.
doi: 10.1002/nbm.3429. Epub 2015 Oct 27. PubMed PMID: 26503172.

3: Falcon SC, Hudson CS, Huang Y, Mortimore M, Golec JM, Charlton PA, Weber P,
Sundaram H. A non-catalytic role of choline kinase alpha is important in
promoting cancer cell survival. Oncogenesis. 2013;2:e38. PubMed PMID: 25522435;
PubMed Central PMCID: PMC3641355.