WARNING: This product is for research use only, not for human or veterinary use.
MedKoo CAT#: 561396
CAS#: 1962931-71-0
Description: JNJ-DGAT2-A is a DGAT2-selective inhibitor. Diacylglycerol acyltransferase (DGAT) catalyzes the final step in triglyceride (TG) synthesis. JNJ-DGAT2-A dose-dependently inhibited the generation of the three major TG species in HepG2 cells.
MedKoo Cat#: 561396
Name: JNJ-DGAT2-A
CAS#: 1962931-71-0
Chemical Formula: C24H16BrFN4O2S
Exact Mass: 522.0161
Molecular Weight: 523.3804
Elemental Analysis: C, 55.08; H, 3.08; Br, 15.27; F, 3.63; N, 10.71; O, 6.11; S, 6.13
This product is not in stock, which may be available by custom synthesis.
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Synonym: JNJ-DGAT2-A; JNJDGAT2A; JNJ DGAT2 A;
IUPAC/Chemical Name: 3-Bromo-4-[2-fluoro-4-({4-oxo-2-[(2-pyridin-2-ylethyl)amino]1,3-thiazol-5(4H)-ylidene}methyl)phenoxy]benzonitrile
InChi Key: ZFRHAMOJHTZHLT-XKZIYDEJSA-N
InChi Code: InChI=1S/C24H16BrFN4O2S/c25-18-11-16(14-27)5-6-20(18)32-21-7-4-15(12-19(21)26)13-22-23(31)30-24(33-22)29-10-8-17-3-1-2-9-28-17/h1-7,9,11-13H,8,10H2,(H,29,30,31)/b22-13-
SMILES Code: N#CC1=CC=C(OC2=CC=C(/C=C(SC(NCCC3=NC=CC=C3)=N4)/C4=O)C=C2F)C(Br)=C1
Appearance: Solid powder
Purity: >98% (or refer to the Certificate of Analysis)
Shipping Condition: Shipped under ambient temperature as non-hazardous chemical. This product is stable enough for a few weeks during ordinary shipping and time spent in Customs.
Storage Condition: Dry, dark and at 0 - 4 C for short term (days to weeks) or -20 C for long term (months to years).
Solubility: Soluble in DMSO
Shelf Life: >2 years if stored properly
Drug Formulation: This drug may be formulated in DMSO
Stock Solution Storage: 0 - 4 C for short term (days to weeks), or -20 C for long term (months).
HS Tariff Code: 2934.99.9001
The following data is based on the product molecular weight 523.3804 Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.
| Concentration / Solvent Volume / Mass | 1 mg | 5 mg | 10 mg |
|---|---|---|---|
| 1 mM | 1.15 mL | 5.76 mL | 11.51 mL |
| 5 mM | 0.23 mL | 1.15 mL | 2.3 mL |
| 10 mM | 0.12 mL | 0.58 mL | 1.15 mL |
| 50 mM | 0.02 mL | 0.12 mL | 0.23 mL |
1: Qi J, Lang W, Geisler JG, et al. The use of stable isotope-labeled glycerol and oleic acid to differentiate the hepatic functions of DGAT1 and -2. Journal of Lipid Research. 2012;53(6):1106-1116. doi:10.1194/jlr.M020156.
