JNJ-DGAT2-A

    WARNING: This product is for research use only, not for human or veterinary use.

MedKoo CAT#: 561396

CAS#: 1962931-71-0

Description: JNJ-DGAT2-A is a DGAT2-selective inhibitor. Diacylglycerol acyltransferase (DGAT) catalyzes the final step in triglyceride (TG) synthesis. JNJ-DGAT2-A dose-dependently inhibited the generation of the three major TG species in HepG2 cells.


Chemical Structure

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JNJ-DGAT2-A
CAS# 1962931-71-0

Theoretical Analysis

MedKoo Cat#: 561396
Name: JNJ-DGAT2-A
CAS#: 1962931-71-0
Chemical Formula: C24H16BrFN4O2S
Exact Mass: 522.0161
Molecular Weight: 523.3804
Elemental Analysis: C, 55.08; H, 3.08; Br, 15.27; F, 3.63; N, 10.71; O, 6.11; S, 6.13

Price and Availability

This product is not in stock, which may be available by custom synthesis. For cost-effective reason, minimum order is 1g (price is usually high, lead time is 2~3 months, depending on the technical challenge). Quote less than 1g will not be provided. To request quote, please email to sales @medkoo.com or click below button.
Note: Price will be listed if it is available in the future.

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Synonym: JNJ-DGAT2-A; JNJDGAT2A; JNJ DGAT2 A;

IUPAC/Chemical Name: 3-Bromo-4-[2-fluoro-4-({4-oxo-2-[(2-pyridin-2-ylethyl)amino]1,3-thiazol-5(4H)-ylidene}methyl)phenoxy]benzonitrile

InChi Key: ZFRHAMOJHTZHLT-XKZIYDEJSA-N

InChi Code: InChI=1S/C24H16BrFN4O2S/c25-18-11-16(14-27)5-6-20(18)32-21-7-4-15(12-19(21)26)13-22-23(31)30-24(33-22)29-10-8-17-3-1-2-9-28-17/h1-7,9,11-13H,8,10H2,(H,29,30,31)/b22-13-

SMILES Code: N#CC1=CC=C(OC2=CC=C(/C=C(SC(NCCC3=NC=CC=C3)=N4)/C4=O)C=C2F)C(Br)=C1

Appearance: Solid powder

Purity: >98% (or refer to the Certificate of Analysis)

Shipping Condition: Shipped under ambient temperature as non-hazardous chemical. This product is stable enough for a few weeks during ordinary shipping and time spent in Customs.

Storage Condition: Dry, dark and at 0 - 4 C for short term (days to weeks) or -20 C for long term (months to years).

Solubility: Soluble in DMSO

Shelf Life: >2 years if stored properly

Drug Formulation: This drug may be formulated in DMSO

Stock Solution Storage: 0 - 4 C for short term (days to weeks), or -20 C for long term (months).

HS Tariff Code: 2934.99.9001

Preparing Stock Solutions

The following data is based on the product molecular weight 523.3804 Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.

Recalculate based on batch purity %
Concentration / Solvent Volume / Mass 1 mg 5 mg 10 mg
1 mM 1.15 mL 5.76 mL 11.51 mL
5 mM 0.23 mL 1.15 mL 2.3 mL
10 mM 0.12 mL 0.58 mL 1.15 mL
50 mM 0.02 mL 0.12 mL 0.23 mL

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1: Qi J, Lang W, Geisler JG, et al. The use of stable isotope-labeled glycerol and oleic acid to differentiate the hepatic functions of DGAT1 and -2. Journal of Lipid Research. 2012;53(6):1106-1116. doi:10.1194/jlr.M020156.