VU6001966

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MedKoo CAT#: 571268

CAS#: 2009052-76-8

Description: VU6001966 is a potent and selective mGlu2 inhibitor and Negative allosteric modulator. VU6001966 has a mGlu2 IC50 = 78 nM and mGlu3 IC50 > 30 μM. It exhibits excellent central nervous system (CNS) penetration and represents an exciting lead series for potential mGlu2 PET tracer development.


Price and Availability

Size Price Shipping out time Quantity
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Pricing updated 2020-10-25. Prices are subject to change without notice.

VU6001966 is not in stock, may be available through custom synthesis. For cost-effective reason, minimum 1 gram order is requested. The product will be characterized by NMR, HPLC and MS analysis. Purity (HPLC) is usually >98%. CoA, QC data, MSDS will be provided when product is successfully made. The estimated lead time is 2-3 months. Please send email to sales@medkoo.com to inquire quote.


Chemical Structure

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Theoretical Analysis

MedKoo Cat#: 571268
Name: VU6001966
CAS#: 2009052-76-8
Chemical Formula: C17H15FN4O2
Exact Mass: 326.1179
Molecular Weight: 326.33
Elemental Analysis: C, 62.57; H, 4.63; F, 5.82; N, 17.17; O, 9.81


Synonym: VU6001966; VU-6001966; VU 6001966

IUPAC/Chemical Name: 4-(4-fluorophenyl)-5-((1-methyl-1H-pyrazol-3-yl)methoxy)picolinamide

InChi Key: SSSNPJKQBYVHBV-UHFFFAOYSA-N

InChi Code: InChI=1S/C17H15FN4O2/c1-22-7-6-13(21-22)10-24-16-9-20-15(17(19)23)8-14(16)11-2-4-12(18)5-3-11/h2-9H,10H2,1H3,(H2,19,23)

SMILES Code: CN1C=CC(COC2=C(C3=CC=C(F)C=C3)C=C(C(N)=O)N=C2)=N1


Technical Data

Appearance:
Solid powder

Purity:
>98% (or refer to the Certificate of Analysis)

Shipping Condition:
Shipped under ambient temperature as non-hazardous chemical. This product is stable enough for a few weeks during ordinary shipping and time spent in Customs.

Storage Condition:
Dry, dark and at 0 - 4 C for short term (days to weeks) or -20 C for long term (months to years).

Solubility:
Soluble in DMSO

Shelf Life:
>2 years if stored properly

Drug Formulation:
This drug may be formulated in DMSO

Stock Solution Storage:
0 - 4 C for short term (days to weeks), or -20 C for long term (months).

HS Tariff Code:
2934.99.9001


Additional Information

Negative allosteric modulators (NAM) are molecules of interest in treating depression-related behaviors, as potentially novel antidepressants.


References

1: Felts AS, Rodriguez AL, Smith KA, Engers JL, Morrison RD, Byers FW, Blobaum AL, Locuson CW, Chang S, Venable DF, Niswender CM, Daniels JS, Conn PJ, Lindsley CW, Emmitte KA. Design of 4-Oxo-1-aryl-1,4-dihydroquinoline-3-carboxamides as Selective Negative Allosteric Modulators of Metabotropic Glutamate Receptor Subtype 2. J Med Chem. 2015 Nov 25;58(22):9027-40. doi:
10.1021/acs.jmedchem.5b01371. Epub 2015 Nov 11. PubMed PMID: 26524606; PubMed Central PMCID: PMC4817271.

2: Bollinger KA, Felts AS, Brassard CJ, Engers JL, Rodriguez AL, Weiner RL, Hyekyung PC, Chang S, Bubser M, Jones CK, Blobaum AL, Niswender CM, Conn JP, Emmitte KA, Lindsley CW. Design and Synthesis of mGlu2 NAMs with Improved Potency and CNS Penetration Based on a Truncated Picolinamide Core. ACS Med Chem. 2017 Aug 3. doi: 10.1021/acsmedchemlett.7b00279. [Epub ahead of print].