VU 6010572

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    WARNING: This product is for research use only, not for human or veterinary use.

MedKoo CAT#: 571266


Description: VU 6010572 is a negative allosteric modulator (NAM) for mGlu. VU 6010572 has an IC50 of 245 nM for mGlu3 with high selectivity among all mGlu receptors. VU 6010572 is highly CNS penetrant.

Price and Availability

Size Price Shipping out time Quantity
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Pricing updated 2020-10-26. Prices are subject to change without notice.

VU 6010572 is not in stock, may be available through custom synthesis. For cost-effective reason, minimum 1 gram order is requested. The product will be characterized by NMR, HPLC and MS analysis. Purity (HPLC) is usually >98%. CoA, QC data, MSDS will be provided when product is successfully made. The estimated lead time is 2-3 months. Please send email to to inquire quote.

Chemical Structure


Theoretical Analysis

MedKoo Cat#: 571266
Name: VU 6010572
Chemical Formula: C20H18FNO3
Exact Mass: 339.1271
Molecular Weight: 339.37
Elemental Analysis: C, 70.78; H, 5.35; F, 5.60; N, 4.13; O, 14.14

Synonym: VU 6010572; VU-6010572; VU6010572

IUPAC/Chemical Name: (S)-1-(4-fluorophenyl)-4-(2-phenoxypropoxy)pyridin-2(1H)-one


InChi Code: InChI=1S/C20H18FNO3/c1-15(25-18-5-3-2-4-6-18)14-24-19-11-12-22(20(23)13-19)17-9-7-16(21)8-10-17/h2-13,15H,14H2,1H3/t15-/m0/s1


Technical Data

Solid powder

>98% (or refer to the Certificate of Analysis)

Shipping Condition:
Shipped under ambient temperature as non-hazardous chemical. This product is stable enough for a few weeks during ordinary shipping and time spent in Customs.

Storage Condition:
Dry, dark and at 0 - 4 C for short term (days to weeks) or -20 C for long term (months to years).

Soluble in DMSO

Shelf Life:
>2 years if stored properly

Drug Formulation:
This drug may be formulated in DMSO

Stock Solution Storage:
0 - 4 C for short term (days to weeks), or -20 C for long term (months).

HS Tariff Code:

Additional Information

Negative allosteric modulators (NAM) are molecules of interest in treating depression-related behaviors, as potentially novel antidepressants.


1: Engers JL, Bollinger KA; Weiner RL, Rodriguez AL, Long MF, Breiner MM, Chang S, Bollinger SR, Bubser M, Jones CK, Morrison RD, Bridges TM, Blobaum AL, Niswender CM, Conn JP, Emmitte KA, Lindsley CW. Design and Synthesis of N‑Aryl Phenoxyethoxy Pyridinones as Highly Selective and CNS Penetrant mGlu3 NAMs. ACS Med Chem. 2017 Aug 15. doi: 10.1021/acsmedchemlett.7b00249. [Epub ahead of print].