WARNING: This product is for research use only, not for human or veterinary use.
MedKoo CAT#: 571255
Description: P22074 is a USP7 inhibitor. It is not as active of an antagonist as are its halogen-substituted related compounds.
MedKoo Cat#: 571255
Chemical Formula: C12H9NO3S2
Exact Mass: 279.0024
Molecular Weight: 279.33
Elemental Analysis: C, 51.60; H, 3.25; N, 5.01; O, 17.18; S, 22.96
This product is not in stock, which may be available by custom synthesis.
For cost-effective reason, minimum order is 1g (price is usually high, lead time is 2~3 months, depending on the technical challenge).
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Synonym: P22074; P-22074; P22074
IUPAC/Chemical Name: 1-(4-nitro-5-(phenylthio)thiophen-2-yl)ethan-1-one
InChi Key: WZNUDHSRSDPPHZ-UHFFFAOYSA-N
InChi Code: InChI=1S/C12H9NO3S2/c1-8(14)11-7-10(13(15)16)12(18-11)17-9-5-3-2-4-6-9/h2-7H,1H3
SMILES Code: O=C(C)C1=CC([N+]([O-])=O)=C(S1)SC2=CC=CC=C2
Appearance: Solid powder
Purity: >98% (or refer to the Certificate of Analysis)
Shipping Condition: Shipped under ambient temperature as non-hazardous chemical. This product is stable enough for a few weeks during ordinary shipping and time spent in Customs.
Storage Condition: Dry, dark and at 0 - 4 C for short term (days to weeks) or -20 C for long term (months to years).
Solubility: Soluble in DMSO
Shelf Life: >2 years if stored properly
Drug Formulation: This drug may be formulated in DMSO
Stock Solution Storage: 0 - 4 C for short term (days to weeks), or -20 C for long term (months).
HS Tariff Code: 2934.99.9001
The following data is based on the product molecular weight 279.33 Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.
|Concentration / Solvent Volume / Mass||1 mg||5 mg||10 mg|
|1 mM||1.15 mL||5.76 mL||11.51 mL|
|5 mM||0.23 mL||1.15 mL||2.3 mL|
|10 mM||0.12 mL||0.58 mL||1.15 mL|
|50 mM||0.02 mL||0.12 mL||0.23 mL|
1: Wu J, Kumar S, Wang F, Wang H, Chen L, Arsenault P, Mattern M, Weinstock J.
Chemical Approaches to Intervening in Ubiquitin Specific Protease 7 (USP7)
Function for Oncology and Immune Oncology Therapies. J Med Chem. 2017 Aug 18.
doi: 10.1021/acs.jmedchem.7b00498. [Epub ahead of print] PubMed PMID: 28768102.