A 26771B

    WARNING: This product is for research use only, not for human or veterinary use.

MedKoo CAT#: 571249

CAS#: 56448-20-5

Description: A 26771B is a macrolide lactone antibiotic.


Chemical Structure

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A 26771B
CAS# 56448-20-5

Theoretical Analysis

MedKoo Cat#: 571249
Name: A 26771B
CAS#: 56448-20-5
Chemical Formula: C20H30O7
Exact Mass: 382.20
Molecular Weight: 382.450
Elemental Analysis: C, 62.81; H, 7.91; O, 29.28

Price and Availability

This product is not in stock, which may be available by custom synthesis. For cost-effective reason, minimum order is 1g (price is usually high, lead time is 2~3 months, depending on the technical challenge). Quote less than 1g will not be provided. To request quote, please email to sales @medkoo.com or click below button.
Note: Price will be listed if it is available in the future.

Request quote for custom synthesis

Synonym: A 26771B; A-26771B; A26771B

IUPAC/Chemical Name: 4-(((6S,16R,E)-16-methyl-2,5-dioxooxacyclohexadec-3-en-6-yl)oxy)-4-oxobutanoic acid

InChi Key: CAOCHWFVLJETKN-SADTYBKJSA-N

InChi Code: InChI=1S/C20H30O7/c1-15-9-7-5-3-2-4-6-8-10-17(16(21)11-13-19(24)26-15)27-20(25)14-12-18(22)23/h11,13,15,17H,2-10,12,14H2,1H3,(H,22,23)/b13-11+/t15-,17+/m1/s1

SMILES Code: O=C(O[C@@H]1C(/C=C/C(O[C@H](C)CCCCCCCCC1)=O)=O)CCC(O)=O

Appearance: Solid powder

Purity: >98% (or refer to the Certificate of Analysis)

Shipping Condition: Shipped under ambient temperature as non-hazardous chemical. This product is stable enough for a few weeks during ordinary shipping and time spent in Customs.

Storage Condition: Dry, dark and at 0 - 4 C for short term (days to weeks) or -20 C for long term (months to years).

Solubility: Soluble in DMSO

Shelf Life: >2 years if stored properly

Drug Formulation: This drug may be formulated in DMSO

Stock Solution Storage: 0 - 4 C for short term (days to weeks), or -20 C for long term (months).

HS Tariff Code: 2934.99.9001

More Info:

Biological target:
In vitro activity:
In vivo activity:

Preparing Stock Solutions

The following data is based on the product molecular weight 382.45 Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.

Recalculate based on batch purity %
Concentration / Solvent Volume / Mass 1 mg 5 mg 10 mg
1 mM 1.15 mL 5.76 mL 11.51 mL
5 mM 0.23 mL 1.15 mL 2.3 mL
10 mM 0.12 mL 0.58 mL 1.15 mL
50 mM 0.02 mL 0.12 mL 0.23 mL
Formulation protocol:
In vitro protocol:
In vivo protocol:

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1: Canova S, Lépine R, Thys A, Baron A, Roche D. Synthesis and biological properties of macrolactam analogs of the natural product macrolide (-)-A26771B. Bioorg Med Chem Lett. 2011 Aug 15;21(16):4768-72. doi: 10.1016/j.bmcl.2011.06.073. Epub 2011 Jun 23. PubMed PMID: 21767951.

2: Michel KH, Demarco PV, Nagarjan R. The isolation and structure elucidation of macrocyclic lactone antibiotic, A26771B. J Antibiot (Tokyo). 1977 Jul;30(7):571-5. PubMed PMID: 142754.

3: Persich P, Llaveria J, Lhermet R, de Haro T, Stade R, Kondoh A, Fürstner A. Increasing the structural span of alkyne metathesis. Chemistry. 2013 Sep 23;19(39):13047-58. doi: 10.1002/chem.201302320. Epub 2013 Sep 3. PubMed PMID: 24038738.

4: Gebauer J, Blechert S. Synthesis of gamma,delta-unsaturated-beta-keto lactones via sequential cross metathesis-lactonization: a facile entry to macrolide antibiotic (-)-A26771B. J Org Chem. 2006 Mar 3;71(5):2021-5. PubMed PMID: 16496989.

5: Stierle AA, Stierle DB, Decato D, Priestley ND, Alverson JB, Hoody J, McGrath K, Klepacki D. The Berkeleylactones, Antibiotic Macrolides from Fungal Coculture. J Nat Prod. 2017 Apr 28;80(4):1150-1160. doi: 10.1021/acs.jnatprod.7b00133. Epub 2017 Mar 22. PubMed PMID: 28326781; PubMed Central PMCID: PMC5467647.

6: Kobayashi Y, Okui H. An efficient synthesis of antibiotic (-)-A26771B. J Org Chem. 2000 Jan 28;65(2):612-5. PubMed PMID: 10813983.