WARNING: This product is for research use only, not for human or veterinary use.
MedKoo CAT#: 571213
Description: A-80b is a synthesized pyridazino[4,5-b]indole derivate. A 80b shows potent and long-lasting antihypertensive activity and lowers blood pressure. The decrease in diastolic pressure was greater than the decrease in systolic pressure and cardiac frequency was not modified significantly. A-80b shows dose-dependent inhibition of the Ca(2+)-induced contraction. A-80b exerts a hypotensive and antihypertensive effect, possibly attributable to vasodilator activity via interference with Ca2+ influx and probably Ca2+ mobilization from intracellular stores.
MedKoo Cat#: 571213
Name: A 80b
Chemical Formula: C16H17N7
Exact Mass: 307.1545
Molecular Weight: 307.36
Elemental Analysis: C, 62.52; H, 5.58; N, 31.90
Synonym: A 80b; A-80b; A80b
IUPAC/Chemical Name: 1H-Pyridazino(4,5-b)indol-1-one, 4-(3,5-dimethyl-1H-pyrazol-1-yl)-2,5-dihydro-, methylhydrazone
InChi Key: LZAUTKZCXBBSMB-UHFFFAOYSA-N
InChi Code: InChI=1S/C16H17N7/c1-9-8-10(2)23(22-9)16-14-13(15(19-17-3)20-21-16)11-6-4-5-7-12(11)18-14/h4-8,17-18H,1-3H3,(H,19,20)
SMILES Code: CC1=CC(C)=NN1C(C(N2)=C/3C4=C2C=CC=C4)=NNC3=N\NC
1: Frechilla D, Bernedo E, Castiella E, Lasheras B, Cenarruzabeitia E, Monge A, Aldana I, Alvarez T, Losa MJ, Font M. Antihypertensive and vasodilator effect of A-80b, a new pyridazino indole derivative. Eur J Pharmacol. 1992 Sep 4 ;219(3):409-14. PubMed PMID: 1425969.