A 80b

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MedKoo CAT#: 571213

CAS#: 135561-94-3

Description: A-80b is a synthesized pyridazino[4,5-b]indole derivate. A 80b shows potent and long-lasting antihypertensive activity and lowers blood pressure. The decrease in diastolic pressure was greater than the decrease in systolic pressure and cardiac frequency was not modified significantly. A-80b shows dose-dependent inhibition of the Ca(2+)-induced contraction. A-80b exerts a hypotensive and antihypertensive effect, possibly attributable to vasodilator activity via interference with Ca2+ influx and probably Ca2+ mobilization from intracellular stores.

Chemical Structure

A 80b
CAS# 135561-94-3

Theoretical Analysis

MedKoo Cat#: 571213
Name: A 80b
CAS#: 135561-94-3
Chemical Formula: C16H17N7
Exact Mass: 307.1545
Molecular Weight: 307.36
Elemental Analysis: C, 62.52; H, 5.58; N, 31.90

Price and Availability

This product is not in stock, which may be available by custom synthesis. For cost-effective reason, minimum order is 1g (price is usually high, lead time is 2~3 months, depending on the technical challenge). Quote less than 1g will not be provided. To request quote, please email to sales @medkoo.com or click below button.
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Synonym: A 80b; A-80b; A80b

IUPAC/Chemical Name: 1H-Pyridazino(4,5-b)indol-1-one, 4-(3,5-dimethyl-1H-pyrazol-1-yl)-2,5-dihydro-, methylhydrazone


InChi Code: InChI=1S/C16H17N7/c1-9-8-10(2)23(22-9)16-14-13(15(19-17-3)20-21-16)11-6-4-5-7-12(11)18-14/h4-8,17-18H,1-3H3,(H,19,20)

SMILES Code: CC1=CC(C)=NN1C(C(N2)=C/3C4=C2C=CC=C4)=NNC3=N\NC

Appearance: Solid powder

Purity: >98% (or refer to the Certificate of Analysis)

Shipping Condition: Shipped under ambient temperature as non-hazardous chemical. This product is stable enough for a few weeks during ordinary shipping and time spent in Customs.

Storage Condition: Dry, dark and at 0 - 4 C for short term (days to weeks) or -20 C for long term (months to years).

Solubility: Soluble in DMSO

Shelf Life: >2 years if stored properly

Drug Formulation: This drug may be formulated in DMSO

Stock Solution Storage: 0 - 4 C for short term (days to weeks), or -20 C for long term (months).

HS Tariff Code: 2934.99.9001

Preparing Stock Solutions

The following data is based on the product molecular weight 307.36 Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.

Recalculate based on batch purity %
Concentration / Solvent Volume / Mass 1 mg 5 mg 10 mg
1 mM 1.15 mL 5.76 mL 11.51 mL
5 mM 0.23 mL 1.15 mL 2.3 mL
10 mM 0.12 mL 0.58 mL 1.15 mL
50 mM 0.02 mL 0.12 mL 0.23 mL

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1: Frechilla D, Bernedo E, Castiella E, Lasheras B, Cenarruzabeitia E, Monge A, Aldana I, Alvarez T, Losa MJ, Font M. Antihypertensive and vasodilator effect of A-80b, a new pyridazino indole derivative. Eur J Pharmacol. 1992 Sep 4 ;219(3):409-14. PubMed PMID: 1425969.