A 80556

    WARNING: This product is for research use only, not for human or veterinary use.

MedKoo CAT#: 571205

CAS#: 114676-82-3

Description: A 80556 is a fluoroquinolone antibiotic with potent antibacterial activity against gram-positive, gram-negative, and anaerobic organisms.


Chemical Structure

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A 80556
CAS# 114676-82-3

Theoretical Analysis

MedKoo Cat#: 571205
Name: A 80556
CAS#: 114676-82-3
Chemical Formula: C21H19ClF3N3O3
Exact Mass: 453.1067
Molecular Weight: 453.85
Elemental Analysis: C, 55.58; H, 4.22; Cl, 7.81; F, 12.56; N, 9.26; O, 10.58

Price and Availability

This product is not in stock, which may be available by custom synthesis. For cost-effective reason, minimum order is 1g (price is usually high, lead time is 2~3 months, depending on the technical challenge). Quote less than 1g will not be provided. To request quote, please email to sales @medkoo.com or click below button.
Note: Price will be listed if it is available in the future.

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Synonym: A 80556; A-80556; A80556

IUPAC/Chemical Name: 3-Quinolinecarboxylic acid, 7-(4-amino-2-methyl-1-pyrrolidinyl)-1-(2,4-difluorophenyl)-6-fluoro-1,4-dihydro-4-oxo-, monohydrochloride, (2S-trans)-

InChi Key: CDDGYQYMKFYFSM-JGAZGGJJSA-N

InChi Code: InChI=1S/C21H18F3N3O3.ClH/c1-10-4-12(25)8-26(10)19-7-18-13(6-16(19)24)20(28)14(21(29)30)9-27(18)17-3-2-11(22)5-15(17)23;/h2-3,5-7,9-10,12H,4,8,25H2,1H3,(H,29,30);1H/t10-,12-;/m0./s1

SMILES Code: O=C(C1=CN(C2=CC=C(F)C=C2F)C3=C(C=C(F)C(N4[C@@H](C)C[C@H](N)C4)=C3)C1=O)O.[H]Cl

Appearance: Solid powder

Purity: >98% (or refer to the Certificate of Analysis)

Shipping Condition: Shipped under ambient temperature as non-hazardous chemical. This product is stable enough for a few weeks during ordinary shipping and time spent in Customs.

Storage Condition: Dry, dark and at 0 - 4 C for short term (days to weeks) or -20 C for long term (months to years).

Solubility: Soluble in DMSO

Shelf Life: >2 years if stored properly

Drug Formulation: This drug may be formulated in DMSO

Stock Solution Storage: 0 - 4 C for short term (days to weeks), or -20 C for long term (months).

HS Tariff Code: 2934.99.9001

Preparing Stock Solutions

The following data is based on the product molecular weight 453.85 Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.

Recalculate based on batch purity %
Concentration / Solvent Volume / Mass 1 mg 5 mg 10 mg
1 mM 1.15 mL 5.76 mL 11.51 mL
5 mM 0.23 mL 1.15 mL 2.3 mL
10 mM 0.12 mL 0.58 mL 1.15 mL
50 mM 0.02 mL 0.12 mL 0.23 mL

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1: Clement JJ, Tanaka SK, Alder J, Vojtko C, Beyer J, Hensey D, Ramer N, McDaniel D, Chu DT. In vitro and in vivo evaluations of A-80556, a new fluoroquinolone. Antimicrob Agents Chemother. 1994 May;38(5):1071-8. PubMed PMID: 8067740; PubMed Central PMCID: PMC188152.

2: Destache CJ, Pakiz CB, Stoysich AM. Pharmacodynamics and pharmacokinetics of A-80556 using microdialysis in a Streptococcus pneumoniae meningitis model. J Antimicrob Chemother. 1996 Dec;38(6):977-85. PubMed PMID: 9023645.

3: Yew WW, Piddock LJ, Li MS, Lyon D, Chan CY, Cheng AF. In-vitro activity of quinolones and macrolides against mycobacteria. J Antimicrob Chemother. 1994 Sep;34(3):343-51. PubMed PMID: 7829409.