A 802715

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    WARNING: This product is for research use only, not for human or veterinary use.

MedKoo CAT#: 571203

CAS#: 107767-58-8

Description: A 802715 is an anti-tumor agent that causes dose-dependent protection against lipopolysaccharide induced lethal shock. It counteracts tumor necrosis factor alpha toxicity. It may regulate cell growth and damage response in human cancer tumor cells.

Price and Availability

Size Price Shipping out time Quantity
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Pricing updated 2020-07-11. Prices are subject to change without notice.

A 802715 is not in stock, may be available through custom synthesis. For cost-effective reason, minimum 1 gram order is requested. The product will be characterized by NMR, HPLC and MS analysis. Purity (HPLC) is usually >98%. CoA, QC data, MSDS will be provided when product is successfully made. The estimated lead time is 2-3 months. Please send email to sales@medkoo.com to inquire quote.

Chemical Structure


Theoretical Analysis

MedKoo Cat#: 571203
Name: A 802715
CAS#: 107767-58-8
Chemical Formula: C16H26N4O3
Exact Mass: 322.2005
Molecular Weight: 322.41
Elemental Analysis: C, 59.61; H, 8.13; N, 17.38; O, 14.89

Synonym: A 802715; A-802715; A802715

IUPAC/Chemical Name: 1H-Purine-2,6-dione, 3,7-dihydro-1-(5-hydroxy-5-methylhexyl)-3-methyl-7-propyl-


InChi Code: InChI=1S/C16H26N4O3/c1-5-9-19-11-17-13-12(19)14(21)20(15(22)18(13)4)10-7-6-8-16(2,3)23/h11,23H,5-10H2,1-4H3


Technical Data

Solid powder

>98% (or refer to the Certificate of Analysis)

Shipping Condition:
Shipped under ambient temperature as non-hazardous chemical. This product is stable enough for a few weeks during ordinary shipping and time spent in Customs.

Storage Condition:
Dry, dark and at 0 - 4 C for short term (days to weeks) or -20 C for long term (months to years).

Soluble in DMSO

Shelf Life:
>2 years if stored properly

Drug Formulation:
This drug may be formulated in DMSO

Stock Solution Storage:
0 - 4 C for short term (days to weeks), or -20 C for long term (months).

HS Tariff Code:


1: Bohm L, Theron T, Binder A. Influence of pentoxifylline, A-802710, propentofylline and A-802715 (Hoechst) on the expression of cell cycle blocks and S-phase content after irradiation damage. Biochim Biophys Acta. 2000 Dec 11;1499(1-2):1-10. PubMed PMID: 11118634.

2: Niehörster M, Schönharting M, Wendel A. A novel xanthine derivative counteracting in vivo tumor necrosis factor alpha toxicity in mice. Circ Shock. 1992 Aug;37(4):270-3. PubMed PMID: 1446384.

3: Hoffmann H, Weis M, Frank G, Birg A, Schönharting MM, Jochum M. Amelioration of endotoxin-induced acute lung injury in pigs by HWA 138 and A 80 2715: new analogs of pentoxifylline. Shock. 1995 Sep;4(3):166-70. PubMed PMID: 8574750.

4: Leist M, Auer-Barth S, Wendel A. Tumor necrosis factor production in the perfused mouse liver and its pharmacological modulation by methylxanthines. J Pharmacol Exp Ther. 1996 Mar;276(3):968-76. PubMed PMID: 8786577.

5: Entzian P, Bitter-Suermann S, Burdon D, Ernst M, Schlaak M, Zabel P. Differences in the anti-inflammatory effects of theophylline and pentoxifylline: important for the development of asthma therapy? Allergy. 1998 Aug;53(8):749-54. PubMed PMID: 9722223.

6: Semmler J, Gebert U, Eisenhut T, Moeller J, Schönharting MM, Alléra A, Endres S. Xanthine derivatives: comparison between suppression of tumour necrosis factor-alpha production and inhibition of cAMP phosphodiesterase activity. Immunology. 1993 Apr;78(4):520-5. PubMed PMID: 8388363; PubMed Central PMCID: PMC1421886.

7: Lin Y, Goebels J, Rutgeerts O, Kasran A, Van Gool S, Ceuppens J, Schönharting M, Waer M. Use of the methylxanthine derivative A802715 in transplantation immunology: I. Strong in vitro inhibitory effects on CD28-costimulated T cell activities. Transplantation. 1997 Jun 27;63(12):1813-8. PubMed PMID: 9210510.

8: Rieneck K, Diamant M, Haahr PM, Schönharting M, Bendtzen K. In vitro immunomodulatory effects of pentoxifylline. Immunol Lett. 1993 Aug;37(2-3):131-8. PubMed PMID: 7505000.

9: Lin Y, Segers C, Mikhalsky D, Schönharting M, Waer M. Xanthines: ideal immunosuppressants for combination with cyclosporine? Transplant Proc. 1996 Dec;28(6):3102. PubMed PMID: 8962202.

10: Lin Y, Segers C, Mikhalsky D, Tjandra-Maga TB, Schönharting M, Waer M. Use of the methylxanthine derivative A802715 in transplantation immunology: II. In vivo experiments. Transplantation. 1997 Jun 27;63(12):1734-8. PubMed PMID: 9210496.

11: Lin Y, Schönharting M, Goebels J, Rutgeerts O, Mikhalsky D, Waer M. Use of methylxanthines (MeXa) as immunosuppressive drugs for organ transplantation. Transplant Proc. 1997 Feb-Mar;29(1-2):1279. PubMed PMID: 9123305.