WARNING: This product is for research use only, not for human or veterinary use.
MedKoo CAT#: 561371
CAS#: 1643593-29-6
Description: Ianthelliformisamine B TFA is an antibiotic enhancer against resistant Gram-negative bacteria.
MedKoo Cat#: 561371
Name: Ianthelliformisamine B TFA
CAS#: 1643593-29-6
Chemical Formula: C26H35Br2F9N4O8
Exact Mass:
Molecular Weight: 862.38
Elemental Analysis: C, 36.21; H, 4.09; Br, 18.53; F, 19.83; N, 6.50; O, 14.84
This product is not in stock, which may be available by custom synthesis.
For cost-effective reason, minimum order is 1g (price is usually high, lead time is 2~3 months, depending on the technical challenge).
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Synonym: Ianthelliformisamine B TFA; Ianthelliformisamine-B TFA; IanthelliformisamineB TFA; Ianthelliformisamine B TFA salt;
IUPAC/Chemical Name: (E)-N-(3-((4-aminobutyl)amino)propyl)-3-(3,5-dibromo-4-methoxyphenyl)acrylamide bis(2,2,2-trifluoroacetate)
InChi Key: FKIKCFCKBQMKRB-TXOOBNKBSA-N
InChi Code: InChI=1S/C17H25Br2N3O2.2C2HF3O2/c1-24-17-14(18)11-13(12-15(17)19)5-6-16(23)22-10-4-9-21-8-3-2-7-20;2*3-2(4,5)1(6)7/h5-6,11-12,21H,2-4,7-10,20H2,1H3,(H,22,23);2*(H,6,7)/b6-5+;;
SMILES Code: O=C(NCCCNCCCCN)/C=C/C1=CC(Br)=C(OC)C(Br)=C1.O=C(O)C(F)(F)F.O=C(O)C(F)(F)F
Appearance: Solid powder
Purity: >98% (or refer to the Certificate of Analysis)
Shipping Condition: Shipped under ambient temperature as non-hazardous chemical. This product is stable enough for a few weeks during ordinary shipping and time spent in Customs.
Storage Condition: Dry, dark and at 0 - 4 C for short term (days to weeks) or -20 C for long term (months to years).
Solubility: Soluble in DMSO
Shelf Life: >2 years if stored properly
Drug Formulation: This drug may be formulated in DMSO
Stock Solution Storage: 0 - 4 C for short term (days to weeks), or -20 C for long term (months).
HS Tariff Code: 2934.99.9001
The following data is based on the product molecular weight 862.38 Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.
| Concentration / Solvent Volume / Mass | 1 mg | 5 mg | 10 mg |
|---|---|---|---|
| 1 mM | 1.15 mL | 5.76 mL | 11.51 mL |
| 5 mM | 0.23 mL | 1.15 mL | 2.3 mL |
| 10 mM | 0.12 mL | 0.58 mL | 1.15 mL |
| 50 mM | 0.02 mL | 0.12 mL | 0.23 mL |
1: Pieri C, Borselli D, Di Giorgio C, De Méo M, Bolla JM, Vidal N, Combes S, Brunel JM. New Ianthelliformisamine derivatives as antibiotic enhancers against resistant Gram-negative bacteria. J Med Chem. 2014 May 22;57(10):4263-72. doi: 10.1021/jm500194e. Epub 2014 May 13. PubMed PMID: 24801877.
2: Khan FA, Ahmad S, Kodipelli N, Shivange G, Anindya R. Syntheses of a library of molecules on the marine natural product ianthelliformisamines platform and their biological evaluation. Org Biomol Chem. 2014 Jun 21;12(23):3847-65. doi: 10.1039/c3ob42537a. PubMed PMID: 24668192.
3: Xu M, Davis RA, Feng Y, Sykes ML, Shelper T, Avery VM, Camp D, Quinn RJ. Ianthelliformisamines A-C, antibacterial bromotyrosine-derived metabolites from the marine sponge Suberea ianthelliformis. J Nat Prod. 2012 May 25;75(5):1001-5. doi: 10.1021/np300147d. Epub 2012 Apr 19. PubMed PMID: 22515429.
