PACA
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    WARNING: This product is for research use only, not for human or veterinary use.

MedKoo CAT#: 561366

CAS#: 1431724-30-9

Description: PACA, also known as N-Propargyl Caffeamide, potentiates NGF-induced neurite outgrowth and attenuates 6-hydroxydopamine neurotoxicity in neuronal culture. Insufficient production of nerve growth factor (NGF) is implicated in Parkinson's disease (PD).


Price and Availability

Size Price Shipping out time Quantity
5mg USD 250 2 Weeks
10mg USD 450 2 Weeks
25mg USD 850 2 Weeks
Inquire bulk and customized quantity

Pricing updated 2020-02-27. Prices are subject to change without notice.

PACA, purity > 98%, is in stock. Current shipping out time is about 2 weeks after order is received. CoA, QC data and MSDS documents are available in one week after order is received.


Chemical Structure

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Theoretical Analysis

MedKoo Cat#: 561366
Name: PACA
CAS#: 1431724-30-9
Chemical Formula: C12H11NO3
Exact Mass: 217.0739
Molecular Weight: 217.22
Elemental Analysis: C, 66.35; H, 5.10; N, 6.45; O, 22.10


Synonym: PACA; N-Propargyl Caffeamide;

IUPAC/Chemical Name: 3-(3,4-Dihydroxyphenyl)-N-2-propyn-1-yl-2-propenamide

InChi Key: HLHSUNWAPXINQU-GQCTYLIASA-N

InChi Code: InChI=1S/C12H11NO3/c1-2-7-13-12(16)6-4-9-3-5-10(14)11(15)8-9/h1,3-6,8,14-15H,7H2,(H,13,16)/b6-4+

SMILES Code: O=C(NCC#C)/C=C/C1=CC=C(O)C(O)=C1


Technical Data

Appearance:
Solid powder

Purity:
>98% (or refer to the Certificate of Analysis)

Shipping Condition:
Shipped under ambient temperature as non-hazardous chemical. This product is stable enough for a few weeks during ordinary shipping and time spent in Customs.

Storage Condition:
Dry, dark and at 0 - 4 C for short term (days to weeks) or -20 C for long term (months to years).

Solubility:
Soluble in DMSO

Shelf Life:
>2 years if stored properly

Drug Formulation:
This drug may be formulated in DMSO

Stock Solution Storage:
0 - 4 C for short term (days to weeks), or -20 C for long term (months).

HS Tariff Code:
2934.99.9001


References

1: Luo D, Zhao J, Cheng Y, Lee SM, Rong J. N-Propargyl Caffeamide (PACA) Ameliorates Dopaminergic Neuronal Loss and Motor Dysfunctions in MPTP Mouse Model of Parkinson's Disease and in MPP(+)-Induced Neurons via Promoting the Conversion of proNGF to NGF. Mol Neurobiol. 2017 Mar 21. doi: 10.1007/s12035-017-0486-6. [Epub ahead of print] PubMed PMID: 28321769.

2: Yang C, Zhao J, Cheng Y, Le XC, Rong J. N-Propargyl Caffeate Amide (PACA) Potentiates Nerve Growth Factor (NGF)-Induced Neurite Outgrowth and Attenuates 6-Hydroxydopamine (6-OHDA)-Induced Toxicity by Activating the Nrf2/HO-1 Pathway. ACS Chem Neurosci. 2015 Sep 16;6(9):1560-9. doi: 10.1021/acschemneuro.5b00115. Epub 2015 Jul 16. PubMed PMID: 26147318.