A 65282

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    WARNING: This product is for research use only, not for human or veterinary use.

MedKoo CAT#: 571169

CAS#: 135906-72-8

Description: A 65282 is an antibacterial isothiazoloquinolone. It induces considerable DNA breakage mediated by calf thymus topoisomerase II. A 65282 is a potent inhibitor of the P4-unknotting reaction.

Price and Availability

Size Price Shipping out time Quantity
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Pricing updated 2020-03-29. Prices are subject to change without notice.

A 65282 is not in stock, may be available through custom synthesis. For cost-effective reason, minimum 1 gram order is requested. The product will be characterized by NMR, HPLC and MS analysis. Purity (HPLC) is usually >98%. CoA, QC data, MSDS will be provided when product is successfully made. The estimated lead time is 2-3 months. Please send email to sales@medkoo.com to inquire quote.

Chemical Structure


Theoretical Analysis

MedKoo Cat#: 571169
Name: A 65282
CAS#: 135906-72-8
Chemical Formula: C17H16F2N4O2S
Exact Mass: 378.0962
Molecular Weight: 378.4
Elemental Analysis: C, 53.96; H, 4.26; F, 10.04; N, 14.81; O, 8.46; S, 8.47

Synonym: A 65282; A-65282; A65282

IUPAC/Chemical Name: Isothiazolo(5,4-b)quinoline-3,4(2H,9H)-dione, 7-(3-amino-1-pyrrolidinyl)-9-cyclopropyl-6,8-difluoro-


InChi Code: InChI=1S/C17H16F2N4O2S/c18-10-5-9-13(12(19)14(10)22-4-3-7(20)6-22)23(8-1-2-8)17-11(15(9)24)16(25)21-26-17/h5,7-8H,1-4,6,20H2,(H,21,25)


Technical Data

Solid powder

>98% (or refer to the Certificate of Analysis)

Shipping Condition:
Shipped under ambient temperature as non-hazardous chemical. This product is stable enough for a few weeks during ordinary shipping and time spent in Customs.

Storage Condition:
Dry, dark and at 0 - 4 C for short term (days to weeks) or -20 C for long term (months to years).

Soluble in DMSO

Shelf Life:
>2 years if stored properly

Drug Formulation:
This drug may be formulated in DMSO

Stock Solution Storage:
0 - 4 C for short term (days to weeks), or -20 C for long term (months).

HS Tariff Code:


1: Kohlbrenner WE, Wideburg N, Weigl D, Saldivar A, Chu DT. Induction of calf thymus topoisomerase II-mediated DNA breakage by the antibacterial isothiazoloquinolones A-65281 and A-65282. Antimicrob Agents Chemother. 1992 Jan;36(1):81-6. PubMed PMID: 1317151; PubMed Central PMCID: PMC189231.