MedKoo Biosciences

Trolox
featured

WARNING: This product is for research use only, not for human or veterinary use.

MedKoo CAT#: 561324

CAS#: 53188-07-1

Description: Trolox is an antioxidant like vitamin E and it is used to reduce oxidative stress or damage. Trolox is also used as a benchmark to assess the potency of other antioxidants. Trolox equivalent antioxidant capacity (TEAC) is a measurement of antioxidant strength based on Trolox, measured in units called Trolox Equivalents (TE).

Chemical Structure

Trolox

CAS# 53188-07-1

Instruction

Theoretical Analysis

MedKoo Cat#: 561324
Name: Trolox
CAS#: 53188-07-1
Chemical Formula: C14H18O4
Exact Mass: 250.12
Molecular Weight: 250.290
Elemental Analysis: C, 67.18; H, 7.25; O, 25.57

Price and Availability

Size	Price	Availability
500mg	USD 250	2 Weeks
1g	USD 450	2 Weeks
Bulk inquiry Welcome, Customer: Please do not inquire quote if your intended use is for a patient since our products are for research use and for chemical synthesis use, not for human use . For in-stock products, we listed price in the web page. You may inquire prices for which sizes were not listed. If no price is listed, this means the product is not in stock at the moment, which may be available via custom synthesis. For cost-effective reason, minimum order of 1g is requested (typically very expensive). The lead time is usually 2-4 months. Quote of less than 1g will not be provided. MedKoo may not offer quote for below reasons: (1) current available synthetic method appears to be extremely expensive which is obviously not affordable to most customers; (2) Key raw material to make the product is temporally not available; (3) DEA controlled substances; (4) the product is under patent protection in customer’s country.

Synonym: Trolox;

IUPAC/Chemical Name: 6-Hydroxy-2,5,7,8-tetramethylchroman-2-carboxylic acid

InChi Key: GLEVLJDDWXEYCO-UHFFFAOYSA-N

InChi Code: InChI=1S/C14H18O4/c1-7-8(2)12-10(9(3)11(7)15)5-6-14(4,18-12)13(16)17/h15H,5-6H2,1-4H3,(H,16,17)

SMILES Code: O=C(C1(C)CCC2=C(O1)C(C)=C(C)C(O)=C2C)O

Appearance: Solid powder

Purity: >98% (or refer to the Certificate of Analysis)

Shipping Condition: Shipped under ambient temperature as non-hazardous chemical. This product is stable enough for a few weeks during ordinary shipping and time spent in Customs.

Storage Condition: Dry, dark and at 0 - 4 C for short term (days to weeks) or -20 C for long term (months to years).

Solubility: Soluble in DMSO

Shelf Life: >2 years if stored properly

Drug Formulation: This drug may be formulated in DMSO

Stock Solution Storage: 0 - 4 C for short term (days to weeks), or -20 C for long term (months).

HS Tariff Code: 2934.99.9001

Product Data:

Product Data

Instruction:

View handling instruction

Preparing Stock Solutions

The following data is based on the product molecular weight 250.290000000000000000000000000000 Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.

Concentration / Solvent Volume / Mass	1 mg	5 mg	10 mg
1 mM	1.15 mL	5.76 mL	11.51 mL
5 mM	0.23 mL	1.15 mL	2.3 mL
10 mM	0.12 mL	0.58 mL	1.15 mL
50 mM	0.02 mL	0.12 mL	0.23 mL

Molarity Calculator

Calculate the mass, volume, or concentration required for a solution.

Mass

Concentration

Volume

M. Wt* g/mol

*When preparing stock solutions always use the batch-specific molecular weight of the product found on the vial label and SDS / CoA (available online).

Reconstitution Calculator

The reconstitution calculator allows you to quickly calculate the volume of a reagent to reconstitute your vial. Simply enter the mass of reagent and the target concentration and the calculator will determine the rest.

Volume (to add to vial)

Mass (in vial)

Desired Reconstitution Concentration

Dilution Calculator

Calculate the dilution required to prepare a stock solution.

Concentration 1

Volume 1

Concentration 2

Volume 2

1: Ghani MA, Barril C, Bedgood DR Jr, Prenzler PD. Measurement of antioxidant activity with the thiobarbituric acid reactive substances assay. Food Chem. 2017 Sep 1;230:195-207. doi: 10.1016/j.foodchem.2017.02.127. Epub 2017 Feb 28. Review. PubMed PMID: 28407901. 2: Prie BE, Iosif L, Tivig I, Stoian I, Giurcaneanu C. Oxidative stress in androgenetic alopecia. J Med Life. 2016 Jan-Mar;9(1):79-83. Review. PubMed PMID: 27974920; PubMed Central PMCID: PMC5152608. 3: Galano A, Castañeda-Arriaga R, Pérez-González A, Tan DX, Reiter RJ. Phenolic Melatonin-Related Compounds: Their Role as Chemical Protectors against Oxidative Stress. Molecules. 2016 Oct 29;21(11). pii: E1442. Review. PubMed PMID: 27801875. 4: Rubio CP, Hernández-Ruiz J, Martinez-Subiela S, Tvarijonaviciute A, Ceron JJ. Spectrophotometric assays for total antioxidant capacity (TAC) in dog serum: an update. BMC Vet Res. 2016 Aug 15;12(1):166. doi: 10.1186/s12917-016-0792-7. Review. PubMed PMID: 27526688; PubMed Central PMCID: PMC4986369. 5: López de Dicastillo C, Rodríguez F, Guarda A, Galotto MJ. Antioxidant films based on cross-linked methyl cellulose and native Chilean berry for food packaging applications. Carbohydr Polym. 2016 Jan 20;136:1052-60. doi: 10.1016/j.carbpol.2015.10.013. Epub 2015 Oct 23. Review. PubMed PMID: 26572446. 6: Sheng R, Tang L, Jiang L, Hong L, Shi Y, Zhou N, Hu Y. Novel 1-Phenyl-3-hydroxy-4-pyridinone Derivatives as Multifunctional Agents for the Therapy of Alzheimer's Disease. ACS Chem Neurosci. 2016 Jan 20;7(1):69-81. doi: 10.1021/acschemneuro.5b00224. Epub 2015 Oct 28. Review. PubMed PMID: 26479744. 7: Van Hung P. Phenolic Compounds of Cereals and Their Antioxidant Capacity. Crit Rev Food Sci Nutr. 2016;56(1):25-35. doi: 10.1080/10408398.2012.708909. Review. PubMed PMID: 25075608. 8: Impellizzeri D, Esposito E, Attley J, Cuzzocrea S. Targeting inflammation: new therapeutic approaches in chronic kidney disease (CKD). Pharmacol Res. 2014 Mar;81:91-102. doi: 10.1016/j.phrs.2014.02.007. Epub 2014 Mar 3. Review. PubMed PMID: 24602801. 9: Luque de Castro MD, Delgado-Povedano MM. Ultrasound: a subexploited tool for sample preparation in metabolomics. Anal Chim Acta. 2014 Jan 2;806:74-84. doi: 10.1016/j.aca.2013.10.053. Epub 2013 Nov 7. Review. PubMed PMID: 24331041. 10: Ravishankar D, Rajora AK, Greco F, Osborn HM. Flavonoids as prospective compounds for anti-cancer therapy. Int J Biochem Cell Biol. 2013 Dec;45(12):2821-31. doi: 10.1016/j.biocel.2013.10.004. Epub 2013 Oct 12. Review. PubMed PMID: 24128857. 11: Ares AM, Nozal MJ, Bernal J. Extraction, chemical characterization and biological activity determination of broccoli health promoting compounds. J Chromatogr A. 2013 Oct 25;1313:78-95. doi: 10.1016/j.chroma.2013.07.051. Epub 2013 Jul 16. Review. PubMed PMID: 23899380. 12: López-Alarcón C, Denicola A. Evaluating the antioxidant capacity of natural products: a review on chemical and cellular-based assays. Anal Chim Acta. 2013 Feb 6;763:1-10. doi: 10.1016/j.aca.2012.11.051. Epub 2012 Dec 5. Review. PubMed PMID: 23340280. 13: Kotani A. [Development of HPLC with high-sensitive and precise electrochemical detection enabling dynamic analysis of compounds of biological importance]. Yakugaku Zasshi. 2012;132(9):985-91. Review. Japanese. PubMed PMID: 23023414. 14: Pinchuk I, Shoval H, Dotan Y, Lichtenberg D. Evaluation of antioxidants: scope, limitations and relevance of assays. Chem Phys Lipids. 2012 Sep;165(6):638-47. doi: 10.1016/j.chemphyslip.2012.05.003. Epub 2012 Jun 18. Review. PubMed PMID: 22721987. 15: Jamesdaniel S, Manohar S, Hinduja S. Is S-nitrosylation of cochlear proteins a critical factor in cisplatin-induced ototoxicity? Antioxid Redox Signal. 2012 Oct 1;17(7):929-33. doi: 10.1089/ars.2012.4656. Epub 2012 May 31. Review. PubMed PMID: 22524268; PubMed Central PMCID: PMC3411336. 16: Bhangoo RS, Hall IE, Reese PP, Parikh CR. Deceased-donor kidney perfusate and urine biomarkers for kidney allograft outcomes: a systematic review. Nephrol Dial Transplant. 2012 Aug;27(8):3305-14. doi: 10.1093/ndt/gfr806. Epub 2012 Apr 11. Review. PubMed PMID: 22498916; PubMed Central PMCID: PMC3716303. 17: Ha T, Tinnefeld P. Photophysics of fluorescent probes for single-molecule biophysics and super-resolution imaging. Annu Rev Phys Chem. 2012;63:595-617. doi: 10.1146/annurev-physchem-032210-103340. Epub 2012 Jan 30. Review. PubMed PMID: 22404588; PubMed Central PMCID: PMC3736144. 18: Moniruzzaman M, Khalil MI, Sulaiman SA, Gan SH. Advances in the analytical methods for determining the antioxidant properties of honey: a review. Afr J Tradit Complement Altern Med. 2011 Oct 2;9(1):36-42. eCollection 2012. Review. PubMed PMID: 23983317; PubMed Central PMCID: PMC3746522. 19: Pahari B, Chakraborty S, Chaudhuri S, Sengupta B, Sengupta PK. Binding and antioxidant properties of therapeutically important plant flavonoids in biomembranes: insights from spectroscopic and quantum chemical studies. Chem Phys Lipids. 2012 May;165(4):488-96. doi: 10.1016/j.chemphyslip.2011.10.006. Epub 2011 Oct 29. Review. PubMed PMID: 22062971. 20: Macone A, Fontana M, Barba M, Botta B, Nardini M, Ghirga F, Calcaterra A, Pecci L, Matarese RM. Antioxidant properties of aminoethylcysteine ketimine decarboxylated dimer: a review. Int J Mol Sci. 2011;12(5):3072-84. doi: 10.3390/ijms12053072. Epub 2011 May 12. Review. PubMed PMID: 21686170; PubMed Central PMCID: PMC3116176.

Your view history

Trolox featured