15-Hexadecynoic acid

    WARNING: This product is for research use only, not for human or veterinary use.

MedKoo CAT#: 561300

CAS#: 99208-90-9

Description: 15-Hexadecynoic acid, also known as Alkynyl Palmitic Acid, is a chemical probe for SCRIB palmitoylation and palmitoyl acyltransferases (PATs). This biochemical can be used to identify and characterize the post-translational S-palmitoylation of proteins with Click Chemistry.

Chemical Structure

15-Hexadecynoic acid
CAS# 99208-90-9

Theoretical Analysis

MedKoo Cat#: 561300
Name: 15-Hexadecynoic acid
CAS#: 99208-90-9
Chemical Formula: C16H28O2
Exact Mass: 252.2089
Molecular Weight: 252.4
Elemental Analysis: C, 76.14; H, 11.18; O, 12.68

Price and Availability

Size Price Availability Quantity
25.0mg USD 450.0 2 Weeks
100.0mg USD 1250.0 2 Weeks
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Synonym: 15-Hexadecynoic acid; 15 Hexadecynoic acid; 15Hexadecynoic acid; Alkynyl Palmitic Acid

IUPAC/Chemical Name: Hexadec-15-ynoic acid


InChi Code: InChI=1S/C16H28O2/c1-2-3-4-5-6-7-8-9-10-11-12-13-14-15-16(17)18/h1H,3-15H2,(H,17,18)


Appearance: Solid powder

Purity: >95% (or refer to the Certificate of Analysis)

Shipping Condition: Shipped under ambient temperature as non-hazardous chemical. This product is stable enough for a few weeks during ordinary shipping and time spent in Customs.

Storage Condition: Dry, dark and at 0 - 4 C for short term (days to weeks) or -20 C for long term (months to years).

Solubility: Soluble in DMSO

Shelf Life: >2 years if stored properly

Drug Formulation: This drug may be formulated in DMSO

Stock Solution Storage: 0 - 4 C for short term (days to weeks), or -20 C for long term (months).

HS Tariff Code: 2934.99.9001

Preparing Stock Solutions

The following data is based on the product molecular weight 252.4 Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.

Recalculate based on batch purity %
Concentration / Solvent Volume / Mass 1 mg 5 mg 10 mg
1 mM 1.15 mL 5.76 mL 11.51 mL
5 mM 0.23 mL 1.15 mL 2.3 mL
10 mM 0.12 mL 0.58 mL 1.15 mL
50 mM 0.02 mL 0.12 mL 0.23 mL

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1: Chan P, Han X, Zheng B, DeRan M, Yu J, Jarugumilli GK, Deng H, Pan D, Luo X, Wu X. Autopalmitoylation of TEAD proteins regulates transcriptional output of the Hippo pathway. Nat Chem Biol. 2016 Apr;12(4):282-9. doi: 10.1038/nchembio.2036. Epub 2016 Feb 22. PubMed PMID: 26900866; PubMed Central PMCID: PMC4798901.

2: Ebersole B, Petko J, Levenson R. Bioorthogonal click chemistry to assay mu-opioid receptor palmitoylation using 15-hexadecynoic acid and immunoprecipitation. Anal Biochem. 2014 Apr 15;451:25-7. doi: 10.1016/j.ab.2014.01.008. Epub 2014 Jan 23. PubMed PMID: 24463015; PubMed Central PMCID: PMC3969759.

3: Aitken AE, Roman LJ, Loughran PA, de la Garza M, Masters BS. Expressed CYP4A4 metabolism of prostaglandin E(1) and arachidonic acid. Arch Biochem Biophys. 2001 Sep 15;393(2):329-38. PubMed PMID: 11556821.

4: Shak S, Reich NO, Goldstein IM, Ortiz de Montellano PR. Leukotriene B4 omega-hydroxylase in human polymorphonuclear leukocytes. Suicidal inactivation by acetylenic fatty acids. J Biol Chem. 1985 Oct 25;260(24):13023-8. PubMed PMID: 2997155.