WARNING: This product is for research use only, not for human or veterinary use.
MedKoo CAT#: 571093
Description: A23887 is a potentially neuroleptic tetracyclic spiro amine that has affinity for dopamine D-2 receptors. It is important for defining the pharmacophore for D-2 antagonist activity due to its limited conformational freedom.
MedKoo Cat#: 571093
Chemical Formula: C22H24ClN
Exact Mass: 337.1597
Molecular Weight: 337.89
Elemental Analysis: C, 78.20; H, 7.16; Cl, 10.49; N, 4.15
This product is not in stock, which may be available by custom synthesis.
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Synonym: A23887; A-23887; A 23887
IUPAC/Chemical Name: 3'-chloro-N,N-dimethyl-10',11'-dihydrospiro[cyclohexane-1,5'-dibenzo[a,d]annulen]-2-en-4-amine
InChi Key: QPNVVIACYJVUOX-UHFFFAOYSA-N
InChi Code: InChI=1S/C22H24ClN/c1-24(2)19-11-13-22(14-12-19)20-6-4-3-5-16(20)7-8-17-9-10-18(23)15-21(17)22/h3-6,9-11,13,15,19H,7-8,12,14H2,1-2H3
SMILES Code: CN(C1CCC2(C3=C(CCC4=C2C=C(Cl)C=C4)C=CC=C3)C=C1)C
Appearance: Solid powder
Purity: >98% (or refer to the Certificate of Analysis)
Shipping Condition: Shipped under ambient temperature as non-hazardous chemical. This product is stable enough for a few weeks during ordinary shipping and time spent in Customs.
Storage Condition: Dry, dark and at 0 - 4 C for short term (days to weeks) or -20 C for long term (months to years).
Solubility: Soluble in DMSO
Shelf Life: >2 years if stored properly
Drug Formulation: This drug may be formulated in DMSO
Stock Solution Storage: 0 - 4 C for short term (days to weeks), or -20 C for long term (months).
HS Tariff Code: 2934.99.9001
The following data is based on the product molecular weight 337.89 Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.
|Concentration / Solvent Volume / Mass||1 mg||5 mg||10 mg|
|1 mM||1.15 mL||5.76 mL||11.51 mL|
|5 mM||0.23 mL||1.15 mL||2.3 mL|
|10 mM||0.12 mL||0.58 mL||1.15 mL|
|50 mM||0.02 mL||0.12 mL||0.23 mL|
1: Froimowitz M, Rämsby S. Conformational properties of semirigid antipsychotic drugs: the pharmacophore for dopamine D-2 antagonist activity. J Med Chem. 1991 May;34(5):1707-14. PubMed PMID: 1674541.