Pargyline
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MedKoo CAT#: 571043

CAS#: 555-57-7

Description: Pargyline is an irreversible selective monoamine oxidase (MAO)-B inhibitor drugwith antihypertensive properties. Pargyline has been found to bind with high affinity to the I2 imidazoline receptor (an allosteric site on the MAO enzyme).


Price and Availability

Size Price Shipping out time Quantity
1g USD 370 2 Weeks
5g USD 890 2 Weeks
Inquire bulk and customized quantity

Pricing updated 2020-07-11. Prices are subject to change without notice.

Pargyline, purity > 98%, is in stock. Current shipping out time is about 2 weeks after order is received. CoA, QC data and MSDS documents are available in one week after order is received.


Chemical Structure

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Theoretical Analysis

MedKoo Cat#: 571043
Name: Pargyline
CAS#: 555-57-7
Chemical Formula: C11H13N
Exact Mass: 159.1048
Molecular Weight: 159.23
Elemental Analysis: C, 82.97; H, 8.23; N, 8.80


Synonym: Pargyline; Eudatin

IUPAC/Chemical Name: Benzenemethanamine, N-methyl-N-2-propynyl-

InChi Key: DPWPWRLQFGFJFI-UHFFFAOYSA-N

InChi Code: InChI=1S/C11H13N/c1-3-9-12(2)10-11-7-5-4-6-8-11/h1,4-8H,9-10H2,2H3

SMILES Code: C#CCN(C)CC1=CC=CC=C1


Technical Data

Appearance:
Solid powder

Purity:
>98% (or refer to the Certificate of Analysis)

Shipping Condition:
Shipped under ambient temperature as non-hazardous chemical. This product is stable enough for a few weeks during ordinary shipping and time spent in Customs.

Storage Condition:
Dry, dark and at 0 - 4 C for short term (days to weeks) or -20 C for long term (months to years).

Solubility:
Soluble in DMSO

Shelf Life:
>2 years if stored properly

Drug Formulation:
This drug may be formulated in DMSO

Stock Solution Storage:
0 - 4 C for short term (days to weeks), or -20 C for long term (months).

HS Tariff Code:
2934.99.9001


References

1: Bazzu G, Rocchitta G, Migheli R, Alvau MD, Zinellu M, Puggioni G, Calia G, Mercanti G, Giusti P, Desole MS, Serra PA. Effects of the neurotoxin MPTP and pargyline protection on extracellular energy metabolites and dopamine levels in the striatum of freely moving rats. Brain Res. 2013 Nov 13;1538:159-71. doi: 10.1016/j.brainres.2013.09.037. Epub 2013 Sep 27. PubMed PMID: 24080403.

2: Lei J, Wu X, Zhu Q. Copper-catalyzed trifluoromethylalkynylation of isocyanides. Org Lett. 2015 May 15;17(10):2322-5. doi: 10.1021/acs.orglett.5b00730. Epub 2015 Apr 23. PubMed PMID: 25905786.

3: Wang J, Edmondson DE. Topological probes of monoamine oxidases A and B in rat liver mitochondria: inhibition by TEMPO-substituted pargyline analogues and inactivation by proteolysis. Biochemistry. 2011 Apr 5;50(13):2499-505. doi: 10.1021/bi101722b. Epub 2011 Mar 7. PubMed PMID: 21341713; PubMed Central PMCID: PMC3068223.

4: Rao BV, Manmode S, Hotha S. Propargyl 1,2-orthoesters for a catalytic and stereoselective synthesis of pyrimidine nucleosides. J Org Chem. 2015 Feb 6;80(3):1499-505. doi: 10.1021/jo502413z. Epub 2015 Jan 8. PubMed PMID: 25539179.