WARNING: This product is for research use only, not for human or veterinary use.

MedKoo CAT#: 561235

CAS#: 1627122-26-2

Description: JG-48 is an inhibitor of Hsp70. JG-48 suppresses phosphorylated and total Tau in Tau-overexpressing HeLa cells, endogenous Tau in neuroblastoma cells, and endogenous Tau in primary neurons from rTg4510 mice, a mouse model of Alzheimer’s disease

Chemical Structure

CAS# 1627122-26-2

Theoretical Analysis

MedKoo Cat#: 561235
Name: JG-48
CAS#: 1627122-26-2
Chemical Formula: C20H16F3N3OS2
Exact Mass: 435.0687
Molecular Weight: 435.48
Elemental Analysis: C, 55.16; H, 3.70; F, 13.09; N, 9.65; O, 3.67; S, 14.72

Price and Availability

This product is not in stock, which may be available by custom synthesis. For cost-effective reason, minimum order is 1g (price is usually high, lead time is 2~3 months, depending on the technical challenge). Quote less than 1g will not be provided. To request quote, please email to sales @medkoo.com or click below button.
Note: Price will be listed if it is available in the future.

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Synonym: JG-48; JG48; JG 48

IUPAC/Chemical Name: (2Z,5E)-3-Ethyl-5-[3-methyl-6-(trifluoromethyl)-2(3H)-benzothiazolylidene]-2-(2-pyridinylmethylene)-4-thiazolidinone


InChi Code: InChI=1S/C20H16F3N3OS2/c1-3-26-16(11-13-6-4-5-9-24-13)29-17(18(26)27)19-25(2)14-8-7-12(20(21,22)23)10-15(14)28-19/h4-11H,3H2,1-2H3/b16-11-,19-17+

SMILES Code: O=C1N(CC)/C(S/C1=C2SC3=CC(C(F)(F)F)=CC=C3N/2C)=C/C4=NC=CC=C4

Appearance: Solid powder

Purity: >98% (or refer to the Certificate of Analysis)

Shipping Condition: Shipped under ambient temperature as non-hazardous chemical. This product is stable enough for a few weeks during ordinary shipping and time spent in Customs.

Storage Condition: Dry, dark and at 0 - 4 C for short term (days to weeks) or -20 C for long term (months to years).

Solubility: Soluble in DMSO

Shelf Life: >2 years if stored properly

Drug Formulation: This drug may be formulated in DMSO

Stock Solution Storage: 0 - 4 C for short term (days to weeks), or -20 C for long term (months).

HS Tariff Code: 2934.99.9001

Preparing Stock Solutions

The following data is based on the product molecular weight 435.48 Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.

Recalculate based on batch purity %
Concentration / Solvent Volume / Mass 1 mg 5 mg 10 mg
1 mM 1.15 mL 5.76 mL 11.51 mL
5 mM 0.23 mL 1.15 mL 2.3 mL
10 mM 0.12 mL 0.58 mL 1.15 mL
50 mM 0.02 mL 0.12 mL 0.23 mL

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1: Abisambra J, Jinwal UK, Miyata Y, Rogers J, Blair L, Li X, Seguin SP, Wang L, Jin Y, Bacon J, Brady S, Cockman M, Guidi C, Zhang J, Koren J, Young ZT, Atkins CA, Zhang B, Lawson LY, Weeber EJ, Brodsky JL, Gestwicki JE, Dickey CA. Allosteric heat shock protein 70 inhibitors rapidly rescue synaptic plasticity deficits by reducing aberrant tau. Biol Psychiatry. 2013 Sep 1;74(5):367-74. doi: 10.1016/j.biopsych.2013.02.027. Epub 2013 Apr 19. PubMed PMID: 23607970; PubMed Central PMCID: PMC3740016.