WARNING: This product is for research use only, not for human or veterinary use.
MedKoo CAT#: 571009
CAS#: 144376-84-1
Description: A-10255 is a complex of thiopeptide antibiotics from Streptomyces gardneri.
MedKoo Cat#: 571009
Name: A-10255
CAS#: 144376-84-1
Chemical Formula: C40H35N13O10S3
Exact Mass: 953.1792
Molecular Weight: 953.98
Elemental Analysis: C, 50.36; H, 3.70; N, 19.09; O, 16.77; S, 10.08
This product is not in stock, which may be available by custom synthesis.
For cost-effective reason, minimum order is 1g (price is usually high, lead time is 2~3 months, depending on the technical challenge).
Quote less than 1g will not be provided. To request quote, please email to sales @medkoo.com or click below button.
Note: Price will be listed if it is available in the future.
Synonym: A 10255, A10255, A-10255
IUPAC/Chemical Name: (12Z,32Z,9Z)-9-ethylidene-6-(1-hydroxyethyl)-17-methyl-21,24-dimethylene-4,7,11,15,19,22-hexaoxo-5,8,12,16,20,23-hexaaza-1(4,2),10(2,5)-dioxazola-3(2,4),14,18(2,5)-trithiazola-2(2,3)-pyridinacyclotetracosaphane-26-carboxamide
InChi Key: VMEMFKILQLCGSB-IOXNKQMXSA-N
InChi Code: InChI=1S/C40H35N13O10S3/c1-6-20-38-44-9-24(63-38)33(58)43-12-27-42-10-25(65-27)34(59)48-17(4)39-45-11-26(66-39)35(60)46-15(2)31(56)47-16(3)37-51-22(13-62-37)29-19(7-8-21(49-29)30(41)55)40-52-23(14-64-40)32(57)53-28(18(5)54)36(61)50-20/h6-11,13-14,17-18,28,54H,2-3,12H2,1,4-5H3,(H2,41,55)(H,43,58)(H,46,60)(H,47,56)(H,48,59)(H,50,61)(H,53,57)/b20-6-
SMILES Code: C/C=C1c2oc(C(NCc3sc(C(NC(C)c4sc(C(NC(C(NC(c5occ(c6nc(C(N)=O)ccc6c7scc(C(NC(C(O)C)C(N/1)=O)=O)n7)n5)=C)=O)=C)=O)cn4)=O)cn3)=O)cn2
Appearance: Solid powder
Purity: >98% (or refer to the Certificate of Analysis)
Shipping Condition: Shipped under ambient temperature as non-hazardous chemical. This product is stable enough for a few weeks during ordinary shipping and time spent in Customs.
Storage Condition: Dry, dark and at 0 - 4 C for short term (days to weeks) or -20 C for long term (months to years).
Solubility: Soluble in DMSO
Shelf Life: >2 years if stored properly
Drug Formulation: This drug may be formulated in DMSO
Stock Solution Storage: 0 - 4 C for short term (days to weeks), or -20 C for long term (months).
HS Tariff Code: 2934.99.9001
The following data is based on the product molecular weight 953.98 Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.
| Concentration / Solvent Volume / Mass | 1 mg | 5 mg | 10 mg |
|---|---|---|---|
| 1 mM | 1.15 mL | 5.76 mL | 11.51 mL |
| 5 mM | 0.23 mL | 1.15 mL | 2.3 mL |
| 10 mM | 0.12 mL | 0.58 mL | 1.15 mL |
| 50 mM | 0.02 mL | 0.12 mL | 0.23 mL |
1: Miyoki S, Ohashi M, Waseda K, Karoji H, Tomaru T. Manufacture of a 10-km-scale radius-of-curvature surface by use of a thin-film coating technique. Opt Lett. 2005 Jun 1;30(11):1399-401. PubMed PMID: 15981546.
2: Favret ME, Boeck LD. Effect of cobalt and cyanocobalamin on biosynthesis of A10255, a thiopeptide antibiotic complex. J Antibiot (Tokyo). 1992 Nov;45(11):1809-11. PubMed PMID: 1468992.
3: Favret ME, Paschal JW, Elzey TK, Boeck LD. Biosynthesis of thiopeptide antibiotic A10255: incorporation of isotopically-labeled precursors. J Antibiot (Tokyo). 1992 Sep;45(9):1499-511. PubMed PMID: 1429236.
4: Boeck LD, Berry DM, Mertz FP, Wetzel RW. A10255, a complex of novel growth-promoting thiopeptide antibiotics produced by a strain of Streptomyces gardneri. Taxonomy and fermentation studies. J Antibiot (Tokyo). 1992 Aug;45(8):1222-30. PubMed PMID: 1399842.
5: Tung RS, Kung L Jr. In vitro effects of a thiopeptide and monensin on ruminal fermentation of soluble carbohydrates. J Dairy Sci. 1993 Apr;76(4):1083-90. PubMed PMID: 8486839.
6: Boeck LD, Favret ME, Wetzel RW. Biosynthesis of thiopeptide antibiotic A10255 in stirred reactors using a chemically defined medium supplemented with continuous nutrient feeds. J Antibiot (Tokyo). 1992 Aug;45(8):1278-85. PubMed PMID: 1399849.
7: Tung RS, Kung L Jr, Slyter LL. In vitro effects of the thiopeptide A10255 on ruminal fermentation and microbial populations. J Dairy Sci. 1992 Sep;75(9):2494-503. PubMed PMID: 1452854.
