A-10255

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WARNING: This product is for research use only, not for human or veterinary use.

MedKoo CAT#: 571009

CAS#: 144376-84-1

Description: A-10255 is a complex of thiopeptide antibiotics from Streptomyces gardneri.

Price and Availability

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Pricing updated 2020-06-06. Prices are subject to change without notice.

A-10255 is not in stock, may be available through custom synthesis. For cost-effective reason, minimum 1 gram order is requested. The product will be characterized by NMR, HPLC and MS analysis. Purity (HPLC) is usually >98%. CoA, QC data, MSDS will be provided when product is successfully made. The estimated lead time is 2-3 months. Please send email to sales@medkoo.com to inquire quote.

Chemical Structure

Theoretical Analysis

MedKoo Cat#: 571009
Name: A-10255
CAS#: 144376-84-1
Chemical Formula: C40H35N13O10S3
Exact Mass: 953.1792
Molecular Weight: 953.98
Elemental Analysis: C, 50.36; H, 3.70; N, 19.09; O, 16.77; S, 10.08

Synonym: A 10255, A10255, A-10255

IUPAC/Chemical Name: (12Z,32Z,9Z)-9-ethylidene-6-(1-hydroxyethyl)-17-methyl-21,24-dimethylene-4,7,11,15,19,22-hexaoxo-5,8,12,16,20,23-hexaaza-1(4,2),10(2,5)-dioxazola-3(2,4),14,18(2,5)-trithiazola-2(2,3)-pyridinacyclotetracosaphane-26-carboxamide

InChi Key: VMEMFKILQLCGSB-IOXNKQMXSA-N

InChi Code: InChI=1S/C40H35N13O10S3/c1-6-20-38-44-9-24(63-38)33(58)43-12-27-42-10-25(65-27)34(59)48-17(4)39-45-11-26(66-39)35(60)46-15(2)31(56)47-16(3)37-51-22(13-62-37)29-19(7-8-21(49-29)30(41)55)40-52-23(14-64-40)32(57)53-28(18(5)54)36(61)50-20/h6-11,13-14,17-18,28,54H,2-3,12H2,1,4-5H3,(H2,41,55)(H,43,58)(H,46,60)(H,47,56)(H,48,59)(H,50,61)(H,53,57)/b20-6-

SMILES Code: C/C=C1c2oc(C(NCc3sc(C(NC(C)c4sc(C(NC(C(NC(c5occ(c6nc(C(N)=O)ccc6c7scc(C(NC(C(O)C)C(N/1)=O)=O)n7)n5)=C)=O)=C)=O)cn4)=O)cn3)=O)cn2

Technical Data

Appearance:

Solid powder

Purity:

>98% (or refer to the Certificate of Analysis)

Shipping Condition:

Shipped under ambient temperature as non-hazardous chemical. This product is stable enough for a few weeks during ordinary shipping and time spent in Customs.

Storage Condition:

Dry, dark and at 0 - 4 C for short term (days to weeks) or -20 C for long term (months to years).

Solubility:

Soluble in DMSO

Shelf Life:

>2 years if stored properly

Drug Formulation:

This drug may be formulated in DMSO

Stock Solution Storage:

0 - 4 C for short term (days to weeks), or -20 C for long term (months).

HS Tariff Code:

2934.99.9001

References

1: Miyoki S, Ohashi M, Waseda K, Karoji H, Tomaru T. Manufacture of a 10-km-scale radius-of-curvature surface by use of a thin-film coating technique. Opt Lett. 2005 Jun 1;30(11):1399-401. PubMed PMID: 15981546.

2: Favret ME, Boeck LD. Effect of cobalt and cyanocobalamin on biosynthesis of A10255, a thiopeptide antibiotic complex. J Antibiot (Tokyo). 1992 Nov;45(11):1809-11. PubMed PMID: 1468992.

3: Favret ME, Paschal JW, Elzey TK, Boeck LD. Biosynthesis of thiopeptide antibiotic A10255: incorporation of isotopically-labeled precursors. J Antibiot (Tokyo). 1992 Sep;45(9):1499-511. PubMed PMID: 1429236.

4: Boeck LD, Berry DM, Mertz FP, Wetzel RW. A10255, a complex of novel growth-promoting thiopeptide antibiotics produced by a strain of Streptomyces gardneri. Taxonomy and fermentation studies. J Antibiot (Tokyo). 1992 Aug;45(8):1222-30. PubMed PMID: 1399842.

5: Tung RS, Kung L Jr. In vitro effects of a thiopeptide and monensin on ruminal fermentation of soluble carbohydrates. J Dairy Sci. 1993 Apr;76(4):1083-90. PubMed PMID: 8486839.

6: Boeck LD, Favret ME, Wetzel RW. Biosynthesis of thiopeptide antibiotic A10255 in stirred reactors using a chemically defined medium supplemented with continuous nutrient feeds. J Antibiot (Tokyo). 1992 Aug;45(8):1278-85. PubMed PMID: 1399849.

7: Tung RS, Kung L Jr, Slyter LL. In vitro effects of the thiopeptide A10255 on ruminal fermentation and microbial populations. J Dairy Sci. 1992 Sep;75(9):2494-503. PubMed PMID: 1452854.

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