WARNING: This product is for research use only, not for human or veterinary use.
MedKoo CAT#: 561209
CAS#: 160359-68-2
Description: Naltalimide, also known as TRK-130, is a unique µ-opioid receptor partial agonist. Naltalimide also enhances the bladder storage function by modulating the afferent limb of the micturition reflex through µ-opioid receptors in the spinal cord. Naltalimide could be a more effective and safer therapeutic agent with a different fashion from antimuscarinics and conventional opioids for overactive bladder.
MedKoo Cat#: 561209
Name: Naltalimide
CAS#: 160359-68-2
Chemical Formula: C28H28N2O5
Exact Mass: 472.1998
Molecular Weight: 472.54
Elemental Analysis: C, 71.17; H, 5.97; N, 5.93; O, 16.93
This product is not in stock, which may be available by custom synthesis.
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Synonym: Naltalimide; TRK-130; TRK130; TRK 130
IUPAC/Chemical Name: N-[(5R, 6R, 14S)-17-(cyclopropylmethyl)-4, 5-epoxy-3,14-dihydroxymorphinan-6-yl] phthalimide
InChi Key: DHAITNWJDOSRBU-IBHWKQIPSA-N
InChi Code: InChI=1S/C28H28N2O5/c31-20-8-7-16-13-21-28(34)10-9-19(30-25(32)17-3-1-2-4-18(17)26(30)33)24-27(28,22(16)23(20)35-24)11-12-29(21)14-15-5-6-15/h1-4,7-8,15,19,21,24,31,34H,5-6,9-14H2/t19-,21-,24+,27+,28-/m1/s1
SMILES Code: O=C(N1[C@H]2[C@@]3([H])[C@]45C6=C(O3)C(O)=CC=C6C[C@@H](N(CC7CC7)CC5)[C@]4(O)CC2)C8=CC=CC=C8C1=O
Appearance: Solid powder
Purity: >98% (or refer to the Certificate of Analysis)
Shipping Condition: Shipped under ambient temperature as non-hazardous chemical. This product is stable enough for a few weeks during ordinary shipping and time spent in Customs.
Storage Condition: Dry, dark and at 0 - 4 C for short term (days to weeks) or -20 C for long term (months to years).
Solubility: Soluble in DMSO
Shelf Life: >2 years if stored properly
Drug Formulation: This drug may be formulated in DMSO
Stock Solution Storage: 0 - 4 C for short term (days to weeks), or -20 C for long term (months).
HS Tariff Code: 2934.99.9001
The following data is based on the product molecular weight 472.54 Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.
| Concentration / Solvent Volume / Mass | 1 mg | 5 mg | 10 mg |
|---|---|---|---|
| 1 mM | 1.15 mL | 5.76 mL | 11.51 mL |
| 5 mM | 0.23 mL | 1.15 mL | 2.3 mL |
| 10 mM | 0.12 mL | 0.58 mL | 1.15 mL |
| 50 mM | 0.02 mL | 0.12 mL | 0.23 mL |
1: Fujimura M, Izumimoto N, Momen S, Yoshikawa S, Kobayashi R, Kanie S, Hirakata M, Komagata T, Okanishi S, Hashimoto T, Yoshimura N, Kawai K. Characteristics of TRK-130 (Naltalimide), a novel opioid ligand, as a new therapeutic agent for overactive bladder. J Pharmacol Exp Ther. 2014 Sep;350(3):543-51. doi: 10.1124/jpet.114.214031. Epub 2014 Jun 13. PubMed PMID: 24928951.
2: Atala A. Re: Characteristics of TRK-130 (naltalimide), a novel opioid ligand, as a new therapeutic agent for overactive bladder. J Urol. 2015 Mar;193(3):1060. doi: 10.1016/j.juro.2014.12.029. Epub 2014 Dec 18. PubMed PMID: 25765428.
3: Wein AJ. Re: Characteristics of TRK-130 (Naltalimide), a Novel Opioid Ligand, as a New Therapeutic Agent for Overactive Bladder. J Urol. 2016 Jan;195(1):223. doi: 10.1016/j.juro.2015.10.078. Epub 2015 Nov 21. PubMed PMID: 26699998.
4: Fujimura M, Izumimoto N, Kanie S, Kobayashi R, Yoshikawa S, Momen S, Hirakata M, Komagata T, Okanishi S, Iwata M, Hashimoto T, Doi T, Yoshimura N, Kawai K. Mechanisms of inhibitory action of TRK-130 (Naltalimide), a μ-opioid receptor partial agonist, on the micturition reflex. Int Urol Nephrol. 2017 Apr;49(4):587-595. doi: 10.1007/s11255-017-1509-y. Epub 2017 Jan 16. PubMed PMID: 28093646.
