Naltalimide

    WARNING: This product is for research use only, not for human or veterinary use.

MedKoo CAT#: 561209

CAS#: 160359-68-2

Description: Naltalimide, also known as TRK-130, is a unique µ-opioid receptor partial agonist. Naltalimide also enhances the bladder storage function by modulating the afferent limb of the micturition reflex through µ-opioid receptors in the spinal cord. Naltalimide could be a more effective and safer therapeutic agent with a different fashion from antimuscarinics and conventional opioids for overactive bladder.


Chemical Structure

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Naltalimide
CAS# 160359-68-2

Theoretical Analysis

MedKoo Cat#: 561209
Name: Naltalimide
CAS#: 160359-68-2
Chemical Formula: C28H28N2O5
Exact Mass: 472.20
Molecular Weight: 472.540
Elemental Analysis: C, 71.17; H, 5.97; N, 5.93; O, 16.93

Price and Availability

This product is not in stock, which may be available by custom synthesis. For cost-effective reason, minimum order is 1g (price is usually high, lead time is 2~3 months, depending on the technical challenge). Quote less than 1g will not be provided. To request quote, please email to sales @medkoo.com or click below button.
Note: Price will be listed if it is available in the future.

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Synonym: Naltalimide; TRK-130; TRK130; TRK 130

IUPAC/Chemical Name: N-[(5R, 6R, 14S)-17-(cyclopropylmethyl)-4, 5-epoxy-3,14-dihydroxymorphinan-6-yl] phthalimide

InChi Key: DHAITNWJDOSRBU-IBHWKQIPSA-N

InChi Code: InChI=1S/C28H28N2O5/c31-20-8-7-16-13-21-28(34)10-9-19(30-25(32)17-3-1-2-4-18(17)26(30)33)24-27(28,22(16)23(20)35-24)11-12-29(21)14-15-5-6-15/h1-4,7-8,15,19,21,24,31,34H,5-6,9-14H2/t19-,21-,24+,27+,28-/m1/s1

SMILES Code: O=C(N1[C@H]2[C@@]3([H])[C@]45C6=C(O3)C(O)=CC=C6C[C@@H](N(CC7CC7)CC5)[C@]4(O)CC2)C8=CC=CC=C8C1=O

Appearance: Solid powder

Purity: >98% (or refer to the Certificate of Analysis)

Shipping Condition: Shipped under ambient temperature as non-hazardous chemical. This product is stable enough for a few weeks during ordinary shipping and time spent in Customs.

Storage Condition: Dry, dark and at 0 - 4 C for short term (days to weeks) or -20 C for long term (months to years).

Solubility: Soluble in DMSO

Shelf Life: >2 years if stored properly

Drug Formulation: This drug may be formulated in DMSO

Stock Solution Storage: 0 - 4 C for short term (days to weeks), or -20 C for long term (months).

HS Tariff Code: 2934.99.9001

More Info:

Biological target:
In vitro activity:
In vivo activity:

Preparing Stock Solutions

The following data is based on the product molecular weight 472.54 Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.

Recalculate based on batch purity %
Concentration / Solvent Volume / Mass 1 mg 5 mg 10 mg
1 mM 1.15 mL 5.76 mL 11.51 mL
5 mM 0.23 mL 1.15 mL 2.3 mL
10 mM 0.12 mL 0.58 mL 1.15 mL
50 mM 0.02 mL 0.12 mL 0.23 mL
Formulation protocol:
In vitro protocol:
In vivo protocol:

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1: Fujimura M, Izumimoto N, Momen S, Yoshikawa S, Kobayashi R, Kanie S, Hirakata M, Komagata T, Okanishi S, Hashimoto T, Yoshimura N, Kawai K. Characteristics of TRK-130 (Naltalimide), a novel opioid ligand, as a new therapeutic agent for overactive bladder. J Pharmacol Exp Ther. 2014 Sep;350(3):543-51. doi: 10.1124/jpet.114.214031. Epub 2014 Jun 13. PubMed PMID: 24928951.

2: Atala A. Re: Characteristics of TRK-130 (naltalimide), a novel opioid ligand, as a new therapeutic agent for overactive bladder. J Urol. 2015 Mar;193(3):1060. doi: 10.1016/j.juro.2014.12.029. Epub 2014 Dec 18. PubMed PMID: 25765428.

3: Wein AJ. Re: Characteristics of TRK-130 (Naltalimide), a Novel Opioid Ligand, as a New Therapeutic Agent for Overactive Bladder. J Urol. 2016 Jan;195(1):223. doi: 10.1016/j.juro.2015.10.078. Epub 2015 Nov 21. PubMed PMID: 26699998.

4: Fujimura M, Izumimoto N, Kanie S, Kobayashi R, Yoshikawa S, Momen S, Hirakata M, Komagata T, Okanishi S, Iwata M, Hashimoto T, Doi T, Yoshimura N, Kawai K. Mechanisms of inhibitory action of TRK-130 (Naltalimide), a μ-opioid receptor partial agonist, on the micturition reflex. Int Urol Nephrol. 2017 Apr;49(4):587-595. doi: 10.1007/s11255-017-1509-y. Epub 2017 Jan 16. PubMed PMID: 28093646.