Kahweol Acetate
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MedKoo CAT#: 540247

CAS#: 81760-47-6 (acetate)

Description: Kahweol Acetate is a semi-synthetic derivative of kahweol, a natural product found in coffee beans. It exhibits a wide variety of biological activities, including inhibiting RANKL-induced osteoclast generation, inducing cell cycle arrest and apoptosis in oral squamous cell carcinoma cells, preventing aflatoxin B1 induced DNA adduct formation, and suppressing H2O2-induced DNA damage and oxidative stress.


Chemical Structure

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Kahweol Acetate
CAS# 81760-47-6 (acetate)

Theoretical Analysis

MedKoo Cat#: 540247
Name: Kahweol Acetate
CAS#: 81760-47-6 (acetate)
Chemical Formula: C22H28O4
Exact Mass: 356.1988
Molecular Weight: 356.46
Elemental Analysis: C, 74.13; H, 7.92; O, 17.95

Price and Availability

Size Price Availability Quantity
10.0mg USD 425.0 2 Weeks
25.0mg USD 700.0 2 Weeks
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Related CAS #: 81760-47-6 (acetate)   6894-43-5 (free)    

Synonym: Kahweol acetate; CCRIS 1520; CCRIS1520; CCRIS-1520

IUPAC/Chemical Name: ((3bS,5aR,7R,8S,10aR,10bS)-7-hydroxy-10b-methyl-3b,4,5,6,7,8,9,10,10a,10b-decahydro-5a,8-methanocyclohepta[5,6]naphtho[2,1-b]furan-7-yl)methyl acetate

InChi Key: OJLWVPDNBQAHRT-RWKVYSHYSA-N

InChi Code: InChI=1S/C22H28O4/c1-14(23)26-13-22(24)12-21-9-5-17-16-7-10-25-18(16)6-8-20(17,2)19(21)4-3-15(22)11-21/h6-8,10,15,17,19,24H,3-5,9,11-13H2,1-2H3/t15-,17+,19-,20+,21+,22-/m0/s1

SMILES Code: CC(OC[C@@]([C@@]1([H])CC2)(O)C[C@@](CC[C@@]34[H])(C1)[C@]2([H])[C@]3(C)C=CC5=C4C=CO5)=O

Appearance: Solid powder

Purity: >98% (or refer to the Certificate of Analysis)

Shipping Condition: Shipped under ambient temperature as non-hazardous chemical. This product is stable enough for a few weeks during ordinary shipping and time spent in Customs.

Storage Condition: Dry, dark and at 0 - 4 C for short term (days to weeks) or -20 C for long term (months to years).

Solubility: Soluble in DMSO

Shelf Life: >2 years if stored properly

Drug Formulation: This drug may be formulated in DMSO

Stock Solution Storage: 0 - 4 C for short term (days to weeks), or -20 C for long term (months).

HS Tariff Code: 2934.99.9001

Certificate of Analysis:

Safety Data Sheet (SDS):

Preparing Stock Solutions

The following data is based on the product molecular weight 356.46 Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.

Recalculate based on batch purity %
Concentration / Solvent Volume / Mass 1 mg 5 mg 10 mg
1 mM 1.15 mL 5.76 mL 11.51 mL
5 mM 0.23 mL 1.15 mL 2.3 mL
10 mM 0.12 mL 0.58 mL 1.15 mL
50 mM 0.02 mL 0.12 mL 0.23 mL

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1: Lam LK, Yee C, Chung A, Wattenberg LW. Use of silver nitrate impregnated
silica cartridges in the separation of kahweol and cafestol esters by preparative
liquid chromatography. J Chromatogr. 1985 Jun 28;328:422-4. PubMed PMID: 2993334.