L-749329

    WARNING: This product is for research use only, not for human or veterinary use.

MedKoo CAT#: 561167

CAS#: 159590-37-1

Description: L-749329 is a dual ET(A)/ET(B) endothelin receptor ligand.


Price and Availability

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L-749329 is not in stock, may be available through custom synthesis. For cost-effective reason, minimum 1 gram order is requested. The product will be characterized by NMR, HPLC and MS analysis. Purity (HPLC) is usually >98%. CoA, QC data, MSDS will be provided when product is successfully made. The estimated lead time is 2-3 months. Please send email to sales@medkoo.com to inquire quote.


Chemical Structure

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Theoretical Analysis

MedKoo Cat#: 561167
Name: L-749329
CAS#: 159590-37-1
Chemical Formula: C28H29NO8S
Exact Mass: 539.1614
Molecular Weight: 539.6
Elemental Analysis: C, 62.33; H, 5.42; N, 2.60; O, 23.72; S, 5.94


Synonym: L-749329; L749329; L 749329

IUPAC/Chemical Name: 4-[1-(1,3-Benzodioxol-5-yl)-2-oxo-2-[(4-propan-2-ylphenyl)sulfonylamino]ethoxy]-3-propylbenzoic acid

InChi Key: JPPYWKVKLSBQJM-UHFFFAOYSA-N

InChi Code: InChI=1S/C28H29NO8S/c1-4-5-19-14-21(28(31)32)9-12-23(19)37-26(20-8-13-24-25(15-20)36-16-35-24)27(30)29-38(33,34)22-10-6-18(7-11-22)17(2)3/h6-15,17,26H,4-5,16H2,1-3H3,(H,29,30)(H,31,32)

SMILES Code: O=C(O)C1=CC=C(OC(C2=CC=C(OCO3)C3=C2)C(NS(=O)(C4=CC=C(C(C)C)C=C4)=O)=O)C(CCC)=C1


Technical Data

Appearance:
Solid powder

Purity:
>98% (or refer to the Certificate of Analysis)

Shipping Condition:
Shipped under ambient temperature as non-hazardous chemical. This product is stable enough for a few weeks during ordinary shipping and time spent in Customs.

Storage Condition:
Dry, dark and at 0 - 4 C for short term (days to weeks) or -20 C for long term (months to years).

Solubility:
Soluble in DMSO

Shelf Life:
>2 years if stored properly

Drug Formulation:
This drug may be formulated in DMSO

Stock Solution Storage:
0 - 4 C for short term (days to weeks), or -20 C for long term (months).

Harmonized System Code:
293490


References

1: Maguire JJ, Kuc RE, Davenport AP. Defining the affinity and receptor sub-type selectivity of four classes of endothelin antagonists in clinically relevant human cardiovascular tissues. Life Sci. 2012 Oct 15;91(13-14):681-6. doi: 10.1016/j.lfs.2012.05.008. Epub 2012 May 23. PubMed PMID: 22634326.

2: Huckle WR, Drag MD, Acker WR, Powers M, McFall RC, Holder DJ, Walsh TF, Schwartz RS, Greenlee WJ, Johnson RG Jr. Effects of L-749,329, an ET(A)/ET(B) endothelin receptor antagonist, in a porcine coronary artery injury model of vascular restenosis. Circulation. 2001 Apr 10;103(14):1899-905. PubMed PMID: 11294810.

3: Hara M, Tozawa F, Itazaki K, Mihara S, Fujimoto M. Endothelin ET(B) receptors show different binding profiles in intact cells and cell membrane preparations. Eur J Pharmacol. 1998 Mar 26;345(3):339-42. PubMed PMID: 9592035.

4: Wu-Wong JR, Chiou WJ, Hoffman DJ, Winn M, von Geldern TW, Opgenorth TJ. Endothelins and endothelin receptor antagonists: binding to plasma proteins. Life Sci. 1996;58(21):1839-47. PubMed PMID: 8637410.

5: Iwasaki T, Mihara S, Shimamura T, Kawakami M, Masui M, Hayasaki-Kajiwara Y, Naya N, Ninomiya M, Fujimoto M, Nakajima M. Pharmacologic characterization of S-1255, a highly potent and orally active endothelin A receptor antagonist. J Cardiovasc Pharmacol. 2001 Apr;37(4):471-82. PubMed PMID: 11300660.

6: Wu-Wong JR, Dixon DB, Chiou WJ, Opgenorth TJ. Endothelin receptor antagonists: effect of serum albumin on potency and comparison of pharmacological characteristics. J Pharmacol Exp Ther. 1997 May;281(2):791-8. PubMed PMID: 9152387.