WARNING: This product is for research use only, not for human or veterinary use.
MedKoo CAT#: 561138
CAS#: 1644545-52-7
Description: Vorasidenib, also known as AG-881, is a potent and selective orally available inhibitor of mutated forms of both isocitrate dehydrogenase type 1 (IDH1, IDH1 [NADP+] soluble) in the cytoplasm and type 2 (IDH2, isocitrate dehydrogenase [NADP+], mitochondrial) in the mitochondria, with potential antineoplastic activity. AG-881 specifically inhibits mutant forms of IDH1 and IDH2, thereby inhibiting the formation of the oncometabolite 2-hydroxyglutarate (2HG) from alpha-ketoglutarate (a-KG). This prevents 2HG-mediated signaling and leads to both an induction of cellular differentiation and an inhibition of cellular proliferation in tumor cells expressing IDH mutations.
MedKoo Cat#: 561138
Name: Vorasidenib
CAS#: 1644545-52-7
Chemical Formula: C14H13ClF6N6
Exact Mass: 414.0794
Molecular Weight: 414.7404
Elemental Analysis: C, 40.54; H, 3.16; Cl, 8.55; F, 27.48; N, 20.26
Synonym: Vorasidenib, AG-881, AG 881, AG881
IUPAC/Chemical Name: 6-(6-chloropyridin-2-yl)-N2,N4-bis((R)-1,1,1-trifluoropropan-2-yl)-1,3,5-triazine-2,4-diamine
InChi Key: QCZAWDGAVJMPTA-RNFRBKRXSA-N
InChi Code: InChI=1S/C14H13ClF6N6/c1-6(13(16,17)18)22-11-25-10(8-4-3-5-9(15)24-8)26-12(27-11)23-7(2)14(19,20)21/h3-7H,1-2H3,(H2,22,23,25,26,27)/t6-,7-/m1/s1
SMILES Code: C[C@@H](NC1=NC(C2=NC(Cl)=CC=C2)=NC(N[C@H](C)C(F)(F)F)=N1)C(F)(F)F
1: Chen J, Yang J, Cao P. The Evolving Landscape in the Development of Isocitrate Dehydrogenase Mutant Inhibitors. Mini Rev Med Chem. 2016;16(16):1344-1358. Review. PubMed PMID: 27292784.
