Lazertinib
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MedKoo CAT#: 206860

CAS#: 1903008-80-9

Description: Lazertinib, also known as YH-25448 and GNS-1480, is an oral active, highly potent, mutant-selective and irreversible EGFR Tyrosine-kinase inhibitors (TKIs) targets both the T790M mutation and activating EGFR mutations while sparing wild type-EGFR. YH25448 is expected to beneficial for the NSCLC patients with brain metastasis due to good blood brain barrier (BBB) penetration property as well as for the treatment of primary lung lesion and extracranial lesions. This study will be conducted to evaluate the safety, tolerability and efficacy of YH25448 in locally advanced or metastatic NSCLC patients with EGFR mutations.


Price and Availability

Size
Price

5mg
USD 140
50mg
USD 950
500mg
USD 3450
Size
Price

10mg
USD 250
100mg
USD 1650
1g
USD 4650
Size
Price

25mg
USD 550
200mg
USD 2650
2g
USD 6450

Lazertinib, purity > 98%, is in stock. The same day shipping out after order is received. Note: The estimated lead time for >2 g may be 2-3 months via custom synthesis. We accept order now.


Chemical Structure

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Theoretical Analysis

MedKoo Cat#: 206860
Name: Lazertinib
CAS#: 1903008-80-9
Chemical Formula: C30H34N8O3
Exact Mass: 554.2754
Molecular Weight: 554.66
Elemental Analysis: C, 64.96; H, 6.18; N, 20.20; O, 8.65


Synonym: Lazertinib; YH-25448; YH 25448; YH25448; GNS-1480; GNS 1480; GNS1480.

IUPAC/Chemical Name: N-{5-[(4-{4-[(dimethylamino)methyl]-3-phenyl-1H-pyrazol-1-yl}pyrimidin-2-yl)amino]-4-methoxy-2-(morpholin-4-yl)phenyl}prop-2-enamide

InChi Key: RRMJMHOQSALEJJ-UHFFFAOYSA-N

InChi Code: InChI=1S/C30H34N8O3/c1-5-28(39)32-23-17-24(26(40-4)18-25(23)37-13-15-41-16-14-37)33-30-31-12-11-27(34-30)38-20-22(19-36(2)3)29(35-38)21-9-7-6-8-10-21/h5-12,17-18,20H,1,13-16,19H2,2-4H3,(H,32,39)(H,31,33,34)

SMILES Code: C=CC(NC1=CC(NC2=NC=CC(N3N=C(C4=CC=CC=C4)C(CN(C)C)=C3)=N2)=C(OC)C=C1N5CCOCC5)=O


Technical Data

Appearance:
Solid powder

Purity:
>98% (or refer to the Certificate of Analysis)

Certificate of Analysis:

Safety Data Sheet (MSDS):

Shipping Condition:
Shipped under ambient temperature as non-hazardous chemical. This product is stable enough for a few weeks during ordinary shipping and time spent in Customs.

Storage Condition:
Dry, dark and at 0 - 4 C for short term (days to weeks) or -20 C for long term (months to years).

Solubility:
Soluble in DMSO

Shelf Life:
>2 years if stored properly

Drug Formulation:
This drug may be formulated in DMSO

Stock Solution Storage:
0 - 4 C for short term (days to weeks), or -20 C for long term (months).

Harmonized System Code:
2934990300


Additional Information

Currently-available EGFR TKIs are ineffective for the treatment of brain metastases (BrM) due to limited blood-brain barrier (BBB) penetration. YH25448 is a potent, highly mutant-selective and irreversible 3rd generation EGFR TKI that is able to penetrate the BBB, and targets both the T790M mutation and activating EGFR mutations while sparing wild type (wt).