WARNING: This product is for research use only, not for human or veterinary use.
MedKoo CAT#: 561082
Description: 2-AEMP TFA is a potent and rapidly acting antagonist of GABA(A)-ρ1 receptors. 2-AEMP is an analog of GABA.
MedKoo Cat#: 561082
Name: 2-AEMP TFA
Chemical Formula: C5H10F3NO5P-5P
Molecular Weight: 252.11
Elemental Analysis: C, 23.82; H, 4.00; F, 22.61; N, 5.56; O, 31.73; P, 12.29
Synonym: 2-AEMP TFA; 2AEMP TFA; 2 AEMP TFA; 2-AEMP; 2 AEMP; 2AEMP
IUPAC/Chemical Name: 2-Aminoethyl methylphosphonate trifluoroacetate salt
InChi Key: RFQBFVSSBOQLIQ-UHFFFAOYSA-M
InChi Code: InChI=1S/C3H10NO3P.C2HF3O2/c1-8(5,6)7-3-2-4;3-2(4,5)1(6)7/h2-4H2,1H3,(H,5,6);(H,6,7)/p-1
SMILES Code: CP(OCCN)([O-])=O.O=C(O)C(F)(F)F
Appearance: Solid powder
Purity: >98% (or refer to the Certificate of Analysis)
Shipping Condition: Shipped under ambient temperature as non-hazardous chemical. This product is stable enough for a few weeks during ordinary shipping and time spent in Customs.
Storage Condition: Dry, dark and at 0 - 4 C for short term (days to weeks) or -20 C for long term (months to years).
Solubility: Soluble in DMSO
Shelf Life: >2 years if stored properly
Drug Formulation: This drug may be formulated in DMSO
Stock Solution Storage: 0 - 4 C for short term (days to weeks), or -20 C for long term (months).
HS Tariff Code: 2934.99.9001
The following data is based on the product molecular weight 252.11 Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.
|Concentration / Solvent Volume / Mass||1 mg||5 mg||10 mg|
|1 mM||1.15 mL||5.76 mL||11.51 mL|
|5 mM||0.23 mL||1.15 mL||2.3 mL|
|10 mM||0.12 mL||0.58 mL||1.15 mL|
|50 mM||0.02 mL||0.12 mL||0.23 mL|
1: Xie A, Yan J, Yue L, Feng F, Mir F, Abdel-Halim H, Chebib M, Le Breton GC, Standaert RF, Qian H, Pepperberg DR. 2-Aminoethyl methylphosphonate, a potent and rapidly acting antagonist of GABA(A)-ρ1 receptors. Mol Pharmacol. 2011 Dec;80(6):965-78. doi: 10.1124/mol.111.071225. Epub 2011 Aug 2. PubMed PMID: 21810922; PubMed Central PMCID: PMC3228531.
2: Wang J, Mojumder DK, Yan J, Xie A, Standaert RF, Qian H, Pepperberg DR, Frishman LJ. In vivo electroretinographic studies of the role of GABAC receptors in retinal signal processing. Exp Eye Res. 2015 Oct;139:48-63. doi: 10.1016/j.exer.2015.07.002. Epub 2015 Jul 8. PubMed PMID: 26164072; PubMed Central PMCID: PMC4573340.