H77-77

    WARNING: This product is for research use only, not for human or veterinary use.

MedKoo CAT#: 561067

CAS#: 21618-99-5

Description: H77-77 is a monoamine oxidase (MAO) inhibitor. In rats, H77-77 produces a pronounced protection against phenelzine within the serotonergic and noradrenergic neurons.


Chemical Structure

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H77-77
CAS# 21618-99-5

Theoretical Analysis

MedKoo Cat#: 561067
Name: H77-77
CAS#: 21618-99-5
Chemical Formula: C10H15NO
Exact Mass: 165.12
Molecular Weight: 165.236
Elemental Analysis: C, 72.69; H, 9.15; N, 8.48; O, 9.68

Price and Availability

This product is not in stock, which may be available by custom synthesis. For cost-effective reason, minimum order is 1g (price is usually high, lead time is 2~3 months, depending on the technical challenge). Quote less than 1g will not be provided. To request quote, please email to sales @medkoo.com or click below button.
Note: Price will be listed if it is available in the future.

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Synonym: H77-77; H77 77; H7777; H77/77

IUPAC/Chemical Name: 5-(2-Aminopropyl)-2-methylphenol

InChi Key: XWLXNPMITZDCHL-UHFFFAOYSA-N

InChi Code: InChI=1S/C10H15NO/c1-7-3-4-9(5-8(2)11)6-10(7)12/h3-4,6,8,12H,5,11H2,1-2H3

SMILES Code: OC1=CC(CC(N)C)=CC=C1C

Appearance: Solid powder

Purity: >98% (or refer to the Certificate of Analysis)

Shipping Condition: Shipped under ambient temperature as non-hazardous chemical. This product is stable enough for a few weeks during ordinary shipping and time spent in Customs.

Storage Condition: Dry, dark and at 0 - 4 C for short term (days to weeks) or -20 C for long term (months to years).

Solubility: Soluble in DMSO

Shelf Life: >2 years if stored properly

Drug Formulation: This drug may be formulated in DMSO

Stock Solution Storage: 0 - 4 C for short term (days to weeks), or -20 C for long term (months).

HS Tariff Code: 2934.99.9001

More Info:

Biological target:
In vitro activity:
In vivo activity:

Preparing Stock Solutions

The following data is based on the product molecular weight 165.24 Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.

Recalculate based on batch purity %
Concentration / Solvent Volume / Mass 1 mg 5 mg 10 mg
1 mM 1.15 mL 5.76 mL 11.51 mL
5 mM 0.23 mL 1.15 mL 2.3 mL
10 mM 0.12 mL 0.58 mL 1.15 mL
50 mM 0.02 mL 0.12 mL 0.23 mL
Formulation protocol:
In vitro protocol:
In vivo protocol:

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1: Fagervall I, Kelder D, Ross SB. Selective inhibition by 4,alpha-dimethyl-m-tyramine (H77/77) and 4-methyl-alpha-ethyl-m-tyramine (H75/12) of the monoamine oxidase within serotonergic and noradrenergic neurons in the rat brain. Naunyn Schmiedebergs Arch Pharmacol. 1988 Aug;338(2):143-7. PubMed PMID: 2460774.

2: Fuxe K, Janson AM, Rosén L, Finnman UB, Tanganelli S, Morari M, Goldstein M, Agnati LF. Evidence for a protective action of the vigilance promoting drug modafinil on the MPTP-induced degeneration of the nigrostriatal dopamine neurons in the black mouse: an immunocytochemical and biochemical analysis. Exp Brain Res. 1992;88(1):117-30. PubMed PMID: 1347270.

3: Leonard BE, Shallice SA. Some neurochemical effects of amphetamine, methylamphetamine and p-bromomethylamphetamine in the rat. Br J Pharmacol. 1971 Feb;41(2):198-212. PubMed PMID: 5572273; PubMed Central PMCID: PMC1703283.

4: Maj J, Melzacka M, Mogilnicka E, Daniel W. Different pharmacokinetic and pharmacological effects following acute and chronic treatment with imipramine. J Neural Transm. 1982;54(3-4):219-28. PubMed PMID: 7130974.

5: Lotti VJ, Clineschmidt BV, Haubrich D, Porter CC. 6-Chloro-2(1-piperazinyl) quinoxaline (CPQ): action on serotonin-induced behavioral responses and interactions with chloromethamphetamine and dimethyl-meta-tyramine. Arch Int Pharmacodyn Ther. 1978 Sep;235(1):103-15. PubMed PMID: 153735.

6: Moret C, Charveron M, Finberg JP, Couzinier JP, Briley M. Biochemical profile of midalcipran (F 2207), 1-phenyl-1-diethyl-aminocarbonyl-2-aminomethyl-cyclopropane (Z) hydrochloride, a potential fourth generation antidepressant drug. Neuropharmacology. 1985 Dec;24(12):1211-9. PubMed PMID: 3005901.