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MedKoo CAT#: 561046

CAS#: Unknown

Description: VBIT-3 is an inhibitor of VDAC1, the outer mitochondrial membrane protein known as voltage-dependent anion channel 1. VBIT-4 inhibits VDAC1 oligomerization, apoptosis, and mitochondrial dysfunction.

Price and Availability

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Pricing updated 2020-07-04. Prices are subject to change without notice.

VBIT-3 was discontinued for commercial reason.

Chemical Structure


Theoretical Analysis

MedKoo Cat#: 561046
Name: VBIT-3
CAS#: Unknown
Chemical Formula: C21H19ClF3N3O3
Exact Mass: 453.1067
Molecular Weight: 453.85
Elemental Analysis: C, 55.58; H, 4.22; Cl, 7.81; F, 12.56; N, 9.26; O, 10.58

Synonym: VBIT-3; VBIT3; VBIT 3

IUPAC/Chemical Name: 1-(4-Chloro-phenyl)-3-[4-(4-trifluoromethoxy-phenyl)-piperazin-1-yl]-pyrrolidine-2,5-dione


InChi Code: InChI=1S/C21H19ClF3N3O3/c22-14-1-3-16(4-2-14)28-19(29)13-18(20(28)30)27-11-9-26(10-12-27)15-5-7-17(8-6-15)31-21(23,24)25/h1-8,18H,9-13H2

SMILES Code: O=C(C(N1CCN(C2=CC=C(OC(F)(F)F)C=C2)CC1)C3)N(C4=CC=C(Cl)C=C4)C3=O

Technical Data

Solid powder

>98% (or refer to the Certificate of Analysis)

Shipping Condition:
Shipped under ambient temperature as non-hazardous chemical. This product is stable enough for a few weeks during ordinary shipping and time spent in Customs.

Storage Condition:
Dry, dark and at 0 - 4 C for short term (days to weeks) or -20 C for long term (months to years).

Soluble in DMSO

Shelf Life:
>2 years if stored properly

Drug Formulation:
This drug may be formulated in DMSO

Stock Solution Storage:
0 - 4 C for short term (days to weeks), or -20 C for long term (months).

HS Tariff Code:


1: Ben-Hail D, Begas-Shvartz R, Shalev M, Shteinfer-Kuzmine A, Gruzman A, Reina S, De Pinto V, Shoshan-Barmatz V. Novel Compounds Targeting the Mitochondrial Protein VDAC1 Inhibit Apoptosis and Protect against Mitochondrial Dysfunction. J Biol Chem. 2016 Nov 25;291(48):24986-25003. Epub 2016 Oct 13. PubMed PMID: 27738100; PubMed Central PMCID: PMC5122769.