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MedKoo CAT#: 561045

CAS#: 2086257-77-2 (racemate)

Description: VBIT-4 is an inhibitor of VDAC1, the outer mitochondrial membrane protein known as voltage-dependent anion channel 1. VBIT-4 inhibits VDAC1 oligomerization, apoptosis, and mitochondrial dysfunction.

Price and Availability

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Pricing updated 2020-09-27. Prices are subject to change without notice.

VBIT-4 was discontinued for commercial reason.

Chemical Structure


Theoretical Analysis

MedKoo Cat#: 561045
Name: VBIT-4
CAS#: 2086257-77-2 (racemate)
Chemical Formula: C21H23ClF3N3O3
Exact Mass: 457.138
Molecular Weight: 457.88
Elemental Analysis: C, 55.09; H, 5.06; Cl, 7.74; F, 12.45; N, 9.18; O, 10.48

Related CAS #: 2086257-77-2 (racemate)   2086268-69-9 (R-isoemr)   2086269-51-2 (S-isomer)  

Synonym: VBIT-4; VBIT 4; VBIT4

IUPAC/Chemical Name: N-(4-chlorophenyl)-4-hydroxy-3-(4-(4-(trifluoromethoxy)phenyl)piperazin-1-yl)butanamide


InChi Code: InChI=1S/C21H23ClF3N3O3/c22-15-1-3-16(4-2-15)26-20(30)13-18(14-29)28-11-9-27(10-12-28)17-5-7-19(8-6-17)31-21(23,24)25/h1-8,18,29H,9-14H2,(H,26,30)


Technical Data

Solid powder

>98% (or refer to the Certificate of Analysis)

Certificate of Analysis:

Safety Data Sheet (SDS):

Shipping Condition:
Shipped under ambient temperature as non-hazardous chemical. This product is stable enough for a few weeks during ordinary shipping and time spent in Customs.

Storage Condition:
Dry, dark and at 0 - 4 C for short term (days to weeks) or -20 C for long term (months to years).

Soluble in DMSO

Shelf Life:
>2 years if stored properly

Drug Formulation:
This drug may be formulated in DMSO

Stock Solution Storage:
0 - 4 C for short term (days to weeks), or -20 C for long term (months).

HS Tariff Code:


1: Ben-Hail D, Begas-Shvartz R, Shalev M, Shteinfer-Kuzmine A, Gruzman A, Reina S, De Pinto V, Shoshan-Barmatz V. Novel Compounds Targeting the Mitochondrial Protein VDAC1 Inhibit Apoptosis and Protect against Mitochondrial Dysfunction. J Biol Chem. 2016 Nov 25;291(48):24986-25003. Epub 2016 Oct 13. PubMed PMID: 27738100; PubMed Central PMCID: PMC5122769.