WARNING: This product is for research use only, not for human or veterinary use.
MedKoo CAT#: 540189
CAS#: 108930-17-2 (HCl)
Description: H7 is a specific protein kinase C inhibitor and protein kinase G inhibitor, which inhibits superoxide release from human neutrophils (PMN) stimulated with phorbol myristate acetate or synthetic diacylglycerol.
MedKoo Cat#: 540189
Name: H7 dihydrochloride
CAS#: 108930-17-2 (HCl)
Chemical Formula: C31H42N6O5S
Exact Mass:
Molecular Weight: 364.285
Elemental Analysis: C, 60.96; H, 6.93; N, 13.76; O, 13.10; S, 5.25
Related CAS #: 108930-17-2 (HCl) 84477-87-2 (free base)
Synonym: H7 dihydrochloride; H7 HCl.
IUPAC/Chemical Name: 5-((2-methylpiperazin-1-yl)sulfonyl)isoquinoline dihydrochloride
InChi Key: OARGPFMFRLLKPF-UHFFFAOYSA-N
InChi Code: InChI=1S/C14H17N3O2S.2ClH/c1-11-9-16-7-8-17(11)20(18,19)14-4-2-3-12-10-15-6-5-13(12)14;;/h2-6,10-11,16H,7-9H2,1H3;2*1H
SMILES Code: O=S(C1=CC=CC2=C1C=CN=C2)(N3C(C)CNCC3)=O.[H]Cl.[H]Cl
Appearance: Solid powder
Purity: >98% (or refer to the Certificate of Analysis)
Shipping Condition: Shipped under ambient temperature as non-hazardous chemical. This product is stable enough for a few weeks during ordinary shipping and time spent in Customs.
Storage Condition: Dry, dark and at 0 - 4 C for short term (days to weeks) or -20 C for long term (months to years).
Solubility: Soluble in DMSO
Shelf Life: >2 years if stored properly
Drug Formulation: This drug may be formulated in DMSO
Stock Solution Storage: 0 - 4 C for short term (days to weeks), or -20 C for long term (months).
HS Tariff Code: 2934.99.9001
| Biological target: | Protein kinase inhibitor H-7 dihydrochloride is a potent PKC (protein kinase C) inhibitor. |
| In vitro activity: | TBD |
| In vivo activity: | TBD |
| Solvent | Max Conc. mg/mL | Max Conc. mM | |
|---|---|---|---|
| Solubility | |||
| DMF | 2.0 | 5.49 | |
| DMSO | 11.32 | 31.07 | |
| Ethanol | 0.25 | 0.69 | |
| PBS (pH 7.2) | 10.0 | 27.45 | |
| Water | 36.43 | 100.0 |
The following data is based on the product molecular weight 364.285 Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.
| Concentration / Solvent Volume / Mass | 1 mg | 5 mg | 10 mg |
|---|---|---|---|
| 1 mM | 1.15 mL | 5.76 mL | 11.51 mL |
| 5 mM | 0.23 mL | 1.15 mL | 2.3 mL |
| 10 mM | 0.12 mL | 0.58 mL | 1.15 mL |
| 50 mM | 0.02 mL | 0.12 mL | 0.23 mL |
| Formulation protocol: | TBD |
| In vitro protocol: | TBD |
| In vivo protocol: | TBD |
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