A-77636 hydrochloride
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    WARNING: This product is for research use only, not for human or veterinary use.

MedKoo CAT#: 526416

CAS#: 145307-34-2

Description: A-77636 hydrochloride is a potent and selective dopamine D1-like receptor agonist.


Chemical Structure

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A-77636 hydrochloride
CAS# 145307-34-2

Theoretical Analysis

MedKoo Cat#: 526416
Name: A-77636 hydrochloride
CAS#: 145307-34-2
Chemical Formula: C20H28ClNO3
Exact Mass: 365.1758
Molecular Weight: 365.898
Elemental Analysis: C, 65.65; H, 7.71; Cl, 9.69; N, 3.83; O, 13.12

Price and Availability

Size Price Availability Quantity
10.0mg USD 390.0 2 Weeks
50.0mg USD 1310.0 2 Weeks
Bulk inquiry

Synonym: A-77636 hydrochloride; A77636 hydrochloride; A77636 hydrochloride

IUPAC/Chemical Name: (1R,3S)-3-(1-adamantyl)-1-(aminomethyl)-3,4-dihydro-1H-isochromene-5,6-diol Hydrochloride

InChi Key: BWHPNJVKFAPVOG-QYFJGNGUSA-N

InChi Code: InChI=1S/C20H27NO3.ClH/c21-10-17-14-1-2-16(22)19(23)15(14)6-18(24-17)20-7-11-3-12(8-20)5-13(4-11)9-20;/h1-2,11-13,17-18,22-23H,3-10,21H2;1H/t11?,12?,13?,17-,18-,20?;/m0./s1

SMILES Code: OC1=C(O)C=CC2=C1C[C@@H](C34CC5CC(C4)CC(C5)C3)O[C@H]2CN.[H]Cl

Appearance: Solid powder

Purity: >98% (or refer to the Certificate of Analysis)

Shipping Condition: Shipped under ambient temperature as non-hazardous chemical. This product is stable enough for a few weeks during ordinary shipping and time spent in Customs.

Storage Condition: Dry, dark and at 0 - 4 C for short term (days to weeks) or -20 C for long term (months to years).

Solubility: Soluble in DMSO

Shelf Life: >2 years if stored properly

Drug Formulation: This drug may be formulated in DMSO

Stock Solution Storage: 0 - 4 C for short term (days to weeks), or -20 C for long term (months).

HS Tariff Code: 2934.99.9001

Preparing Stock Solutions

The following data is based on the product molecular weight 365.898 Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.

Recalculate based on batch purity %
Concentration / Solvent Volume / Mass 1 mg 5 mg 10 mg
1 mM 1.15 mL 5.76 mL 11.51 mL
5 mM 0.23 mL 1.15 mL 2.3 mL
10 mM 0.12 mL 0.58 mL 1.15 mL
50 mM 0.02 mL 0.12 mL 0.23 mL

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7: Blanchet P, Bédard PJ, Britton DR, Kebabian JW. Differential effect of selective D-1 and D-2 dopamine receptor agonists on levodopa-induced dyskinesia in 1-methyl-4-phenyl-1,2,3,6-tetrahydropyridine- exposed monkeys. J Pharmacol Exp Ther. 1993 Oct;267(1):275-9. PubMed PMID: 7901395.

8: Domino EF, Sheng J. Relative potency and efficacy of some dopamine agonists with varying selectivities for D1 and D2 receptors in MPTP-induced hemiparkinsonian monkeys. J Pharmacol Exp Ther. 1993 Jun;265(3):1387-91. Erratum in: J Pharmacol Exp Ther 1993 Oct;267(1):566. PubMed PMID: 8099621.

9: Asin KE, Wirtshafter D. Effects of repeated dopamine D1 receptor stimulation on rotation and c-fos expression. Eur J Pharmacol. 1993 Apr 22;235(1):167-8. PubMed PMID: 8100194.

10: Kebabian JW, Britton DR, DeNinno MP, Perner R, Smith L, Jenner P, Schoenleber R, Williams M. A-77636: a potent and selective dopamine D1 receptor agonist with antiparkinsonian activity in marmosets. Eur J Pharmacol. 1992 Dec 15;229(2-3):203-9. PubMed PMID: 1362704.