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A-77636 hydrochloride

    WARNING: This product is for research use only, not for human or veterinary use.

MedKoo CAT#: 526416

CAS#: 145307-34-2

Description: A-77636 hydrochloride is a potent and selective dopamine D1-like receptor agonist.


Price and Availability

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A-77636 hydrochloride is not in stock, may be available through custom synthesis. For cost-effective reason, minimum 1 gram order is requested. The product will be characterized by NMR, HPLC and MS analysis. Purity (HPLC) is usually >98%. CoA, QC data, MSDS will be provided when product is successfully made. The estimated lead time is 2-3 months. Please send email to sales@medkoo.com to inquire quote.


Chemical Structure

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Theoretical Analysis

MedKoo Cat#: 526416
Name: A-77636 hydrochloride
CAS#: 145307-34-2
Chemical Formula: C20H28ClNO3
Exact Mass: 365.1758
Molecular Weight: 365.898
Elemental Analysis: C, 65.65; H, 7.71; Cl, 9.69; N, 3.83; O, 13.12


Synonym: A-77636 hydrochloride; A77636 hydrochloride; A77636 hydrochloride

IUPAC/Chemical Name: (1R,3S)-3-(1-adamantyl)-1-(aminomethyl)-3,4-dihydro-1H-isochromene-5,6-diol Hydrochloride

InChi Key: BWHPNJVKFAPVOG-QYFJGNGUSA-N

InChi Code: InChI=1S/C20H27NO3.ClH/c21-10-17-14-1-2-16(22)19(23)15(14)6-18(24-17)20-7-11-3-12(8-20)5-13(4-11)9-20;/h1-2,11-13,17-18,22-23H,3-10,21H2;1H/t11?,12?,13?,17-,18-,20?;/m0./s1

SMILES Code: OC1=C(O)C=CC2=C1C[C@@H](C34CC5CC(C4)CC(C5)C3)O[C@H]2CN.[H]Cl


Technical Data

Appearance:
Solid powder

Purity:
>98% (or refer to the Certificate of Analysis)

Shipping Condition:
Shipped under ambient temperature as non-hazardous chemical. This product is stable enough for a few weeks during ordinary shipping and time spent in Customs.

Storage Condition:
Dry, dark and at 0 - 4 C for short term (days to weeks) or -20 C for long term (months to years).

Solubility:
Soluble in DMSO

Shelf Life:
>2 years if stored properly

Drug Formulation:
This drug may be formulated in DMSO

Stock Solution Storage:
0 - 4 C for short term (days to weeks), or -20 C for long term (months).

Harmonized System Code:
293490


References

1: D'Aquila PS, Panin F, Cossu M, Peana AT, Serra G. Dopamine D1 receptor agonists induce penile erections in rats. Eur J Pharmacol. 2003 Jan 26;460(1):71-4. PubMed PMID: 12535862.

2: Ekesbo A, Andrén PE, Gunne LM, Sonesson C, Tedroff J. Motor effects of (-)-OSU6162 in primates with unilateral 6-hydroxydopamine lesions. Eur J Pharmacol. 2000 Feb 18;389(2-3):193-9. PubMed PMID: 10688984.

3: Pearce RK, Jackson M, Britton DR, Shiosaki K, Jenner P, Marsden CD. Actions of the D1 agonists A-77636 and A-86929 on locomotion and dyskinesia in MPTP-treated L-dopa-primed common marmosets. Psychopharmacology (Berl). 1999 Feb;142(1):51-60. PubMed PMID: 10102782.

4: Grondin R, Bédard PJ, Britton DR, Shiosaki K. Potential therapeutic use of the selective dopamine D1 receptor agonist, A-86929: an acute study in parkinsonian levodopa-primed monkeys. Neurology. 1997 Aug;49(2):421-6. PubMed PMID: 9270571.

5: Blanchet PJ, Grondin R, Bédard PJ, Shiosaki K, Britton DR. Dopamine D1 receptor desensitization profile in MPTP-lesioned primates. Eur J Pharmacol. 1996 Aug 1;309(1):13-20. PubMed PMID: 8864687.

6: Wirtshafter D, Asin KE. Interactive effects of stimulation of D1 and D2 dopamine receptors on fos-like immunoreactivity in the normosensitive rat striatum. Brain Res Bull. 1994;35(1):85-91. PubMed PMID: 7953762.

7: Blanchet P, Bédard PJ, Britton DR, Kebabian JW. Differential effect of selective D-1 and D-2 dopamine receptor agonists on levodopa-induced dyskinesia in 1-methyl-4-phenyl-1,2,3,6-tetrahydropyridine- exposed monkeys. J Pharmacol Exp Ther. 1993 Oct;267(1):275-9. PubMed PMID: 7901395.

8: Domino EF, Sheng J. Relative potency and efficacy of some dopamine agonists with varying selectivities for D1 and D2 receptors in MPTP-induced hemiparkinsonian monkeys. J Pharmacol Exp Ther. 1993 Jun;265(3):1387-91. Erratum in: J Pharmacol Exp Ther 1993 Oct;267(1):566. PubMed PMID: 8099621.

9: Asin KE, Wirtshafter D. Effects of repeated dopamine D1 receptor stimulation on rotation and c-fos expression. Eur J Pharmacol. 1993 Apr 22;235(1):167-8. PubMed PMID: 8100194.

10: Kebabian JW, Britton DR, DeNinno MP, Perner R, Smith L, Jenner P, Schoenleber R, Williams M. A-77636: a potent and selective dopamine D1 receptor agonist with antiparkinsonian activity in marmosets. Eur J Pharmacol. 1992 Dec 15;229(2-3):203-9. PubMed PMID: 1362704.