WARNING: This product is for research use only, not for human or veterinary use.

MedKoo CAT#: 551005

CAS#: 327077-97-4

Description: 41F5 is anti-fugal agent. 41F5 is highly active against Histoplasma yeast (MIC50 0.4-0.8 μM). 41F5 has fungistatic activity against Histoplasma yeast at micromolar concentrations, with a 50% inhibitory concentration (IC50) of 0.87 μM, and has the greatest selectivity for yeast (at least 62-fold) relative to host cells. 41F5 inhibits Histoplasma growth in liquid culture and similarly inhibits yeast cells within macrophages, the actual host environment of this fungal pathogen during infection.

Price and Availability




41F5 is not in stock, may be available through custom synthesis. For cost-effective reason, minimum 1 gram order is requested. The product will be characterized by NMR, HPLC and MS analysis. Purity (HPLC) is usually >98%. CoA, QC data, MSDS will be provided when product is successfully made. The estimated lead time is 2-3 months. Please send email to sales@medkoo.com to inquire quote.

Chemical Structure


Theoretical Analysis

MedKoo Cat#: 551005
Name: 41F5
CAS#: 327077-97-4
Chemical Formula: C21H22N2OS
Exact Mass: 350.1453
Molecular Weight: 350.48
Elemental Analysis: C, 71.97; H, 6.33; N, 7.99; O, 4.56; S, 9.15

Synonym: 41F5; 41F-5; 41F 5

IUPAC/Chemical Name: Cyclohexanecarboxylic acid (5-naphthalen-1-ylmethyl-thiazol-2-yl)-amide


InChi Code: InChI=1S/C21H22N2OS/c24-20(16-8-2-1-3-9-16)23-21-22-14-18(25-21)13-17-11-6-10-15-7-4-5-12-19(15)17/h4-7,10-12,14,16H,1-3,8-9,13H2,(H,22,23,24)


Technical Data

Solid powder

>98% (or refer to the Certificate of Analysis)

Shipping Condition:
Shipped under ambient temperature as non-hazardous chemical. This product is stable enough for a few weeks during ordinary shipping and time spent in Customs.

Storage Condition:
Dry, dark and at 0 - 4 C for short term (days to weeks) or -20 C for long term (months to years).

Soluble in DMSO

Shelf Life:
>2 years if stored properly

Drug Formulation:
This drug may be formulated in DMSO

Stock Solution Storage:
0 - 4 C for short term (days to weeks), or -20 C for long term (months).

Harmonized System Code:


1: Khalil A, Edwards JA, Rappleye CA, Tjarks W. Design, synthesis, and biological evaluation of aminothiazole derivatives against the fungal pathogens Histoplasma capsulatum and Cryptococcus neoformans. Bioorg Med Chem. 2015 Feb 1;23(3):532-47. doi: 10.1016/j.bmc.2014.12.006. Epub 2014 Dec 10. PubMed PMID: 25543205; PubMed Central PMCID: PMC4302056.

2: Edwards JA, Kemski MM, Rappleye CA. Identification of an aminothiazole with antifungal activity against intracellular Histoplasma capsulatum. Antimicrob Agents Chemother. 2013 Sep;57(9):4349-59. doi: 10.1128/AAC.00459-13. Epub 2013 Jul 1. PubMed PMID: 23817367; PubMed Central PMCID: PMC3754333.