WARNING: This product is for research use only, not for human or veterinary use.
MedKoo CAT#: 551005
Description: 41F5 is anti-fugal agent. 41F5 is highly active against Histoplasma yeast (MIC50 0.4-0.8 μM). 41F5 has fungistatic activity against Histoplasma yeast at micromolar concentrations, with a 50% inhibitory concentration (IC50) of 0.87 μM, and has the greatest selectivity for yeast (at least 62-fold) relative to host cells. 41F5 inhibits Histoplasma growth in liquid culture and similarly inhibits yeast cells within macrophages, the actual host environment of this fungal pathogen during infection.
MedKoo Cat#: 551005
Chemical Formula: C21H22N2OS
Exact Mass: 350.1453
Molecular Weight: 350.48
Elemental Analysis: C, 71.97; H, 6.33; N, 7.99; O, 4.56; S, 9.15
Synonym: 41F5; 41F-5; 41F 5
IUPAC/Chemical Name: Cyclohexanecarboxylic acid (5-naphthalen-1-ylmethyl-thiazol-2-yl)-amide
InChi Key: WJAMFZVSJYMDDT-UHFFFAOYSA-N
InChi Code: InChI=1S/C21H22N2OS/c24-20(16-8-2-1-3-9-16)23-21-22-14-18(25-21)13-17-11-6-10-15-7-4-5-12-19(15)17/h4-7,10-12,14,16H,1-3,8-9,13H2,(H,22,23,24)
SMILES Code: O=C(C1CCCCC1)NC2=NC=C(CC3=C4C=CC=CC4=CC=C3)S2
1: Khalil A, Edwards JA, Rappleye CA, Tjarks W. Design, synthesis, and biological evaluation of aminothiazole derivatives against the fungal pathogens Histoplasma capsulatum and Cryptococcus neoformans. Bioorg Med Chem. 2015 Feb 1;23(3):532-47. doi: 10.1016/j.bmc.2014.12.006. Epub 2014 Dec 10. PubMed PMID: 25543205; PubMed Central PMCID: PMC4302056.
2: Edwards JA, Kemski MM, Rappleye CA. Identification of an aminothiazole with antifungal activity against intracellular Histoplasma capsulatum. Antimicrob Agents Chemother. 2013 Sep;57(9):4349-59. doi: 10.1128/AAC.00459-13. Epub 2013 Jul 1. PubMed PMID: 23817367; PubMed Central PMCID: PMC3754333.